Coronary angiography was performed in 90 patients with acute non-Q wave myocardial infarction (non-Q MI) - 68 men and 22 women aged 32-78 years (mean age 64,5±2,2 years). Endovascular intervention included transluminal angioplasty and/or coronary artery stenting, with balloon catheters and B x Sonic stents (Johnson and Johnson Corp.). All patients received standard therapy of aspirin, beta-blockers, ACE inhibitors, anticoagulants, and clopidogrel. For patients with non-Q MI, one-vessel coronary artery pathology was most typical; two- and three-vessel pathology prevalence was similar. In 8,9 % of the cases, no hemodynamically significant coronary artery pathology was observed.

In total, 1283 patients with coronary heart disease and fist-diagnosed atrial flutter (AFL) episodes were followed up from 1996 to 2007. In all participants, AF was treated with transoesophageal electrocardiostimulation (TOECS). Sinus rhythm was restored in 83,48 %: in 67,3 % without any antiarrhythmic therapy (AAT), and in others - with AAT before TOECS. The best effect was observed in patients receiving amiodarone or its combination with chinidin durules. Only in 2,88 %, AFL or atrial fibrillation remained after TOECS.

The study investigated right ventricular (RV) remodeling during chronic heart failure (CHF) progression in patients with post-infarction cardiosclerosis (PICS). In total, 69 PICS patients and 14 healthy controls were examined. RV length and volume, its systolic and diastolic function were assessed by echocardiography method. At CHF Stages I-IIA, no substantial changes in RV volume and function were observed, but Stage I was characterized by significant RV length reduction, comparing to the controls. At CHF Stage IIB, RV length and volume were significantly increased, and systolic and diastolic dysfunction was observed. It could be concluded that RV remodeling in PICS patients starts at CHF Stage I already, due not to increased RV load, but to heart anatomy features, as interventricular septum is common for both ventriculi.

Lymphocyte apoptosis and functional activity were studied in 60 women with arterial hypertension and metabolic disturbances (AH) and 60 women with isolated systolic AH (ISAH). Cell apoptosis was assessed by flow cytometry method (propidium iodide technique). In AH patients, in contract to ISAH participants, T and B-lymphocyte deficiency was observed, and lymphocyte proliferation after mitogenic stimulation was reduced. There was a substantial inverse correlation between peripheral blood lymphocyte count and various apoptosis markers, as well as apoptosis associations with the levels of insulin resistance, obesity and dyslipidemia in AH women.

The following changes in lipid profile of children and adolescents with arterial hypertension (AH) were observed: reduction in high-density lipoprotein cholesterol (HDL-CH) and HDL-CH % comparing to total CH; increase in atherogenicity index, LDL-CH/HDL-CH ratio and triglycerides. These changes were typical for highly atherogenic Type IV dyslipoproteinemia (WHO). AH children and adolescents are at early risk of atherosclerosis, and in need for detailed laboratory and instrumental examination, for timely atherosclerosis diagnostics and treatment.

The study included 25 men (mean age 29,24±0,76 years) with Stage I arterial hypertension (AH I) and 25 healthy male controls (mean age 30,27±0,59 years). Both groups underwent 24-hour blood pressure monitoring (BPM), echocardiography (EchoCG) with Doppler ultrasound, heart rate variability (HRV) assessment and measurement of serum cholesterol and its fractions. Analysing correlations between autonomous regulation parameters, cholesterol and cholesterol fractions, and myocardial structure and function, it was observed that in AH I patients, both the number and strength of correlations were greater than in healthy controls. It could point to greater rigidity of neuro-humoral cardiovascular regulation in AH I patients, comparing to healthy individuals.

Arterial structure and function were examined by ultrasound and oscillometry methods in 157 smoking and 45 nonsmoking men aged 20-75 years. In male smokers, increased intima-media thickness of common carotid artery (CCA IMT) was observed from the age of 40 years, and endothelial dysfunction, manifested in reduced endothelium-dependent vasodilatation - from the age of 35-38 years, which is 10 years earlier than in non-smoking males. In smoking men, CCA IMT correlated with age, smoking index, left ventricular myocardial mass index, and pulse wave velocity.

The study investigated ACE inhibitor lisinopril (Diroton, Gedeon Richter, Hungary) effects on platelet aggregation in patients with arterial hypertension (AH) and impaired glucose tolerance (IGT). Lisinopril was administered to 35 patients for 12 weeks. Dynamics of lipid profile, plasma and platelet lipid peroxidation, blood and platelet antioxidant potential, and platelet aggregation were assessed. Statistical methods included t-test. Lisinopril therapy in AH and IGT patients improved platelet aggregation and reduced peroxidation syndrome.

The combination of verapamil retard and enalapril, or verapamil retard and indapamide SR similarly and significantly increased high-density lipoprotein cholesterol and stable NO2 metabolite levels, reducing platelet aggregation in patients with metabolic syndrome (MS). Compared to the combination of verapamil retard and indapamide SR, the combination of verapamil retard and enalapril significantly reduced atherogenicity coefficient, glycated hemoglobin, glucose and soluble fibrin-monomer complex levels, increasing nitrite concentration and activating plasminogen.