MARKERS OF ACCELERATED CONVERSION OF DIABETES MELLITUS IN VARIOUS CARDIOVASCULAR RISK PATIENTS

Abstract

Aim. To assess the early disorders of carbohydrate metabolism and risk of diabetes development (DM) among males with different level of cardiovascular risk (CVR) by SCORE.

Material and methods. Totally, 300 men included, age 40-59 with one or more risk factors. Methods of study included questionnaires, standard clinical, instrumental and laboratory studies. Early disorders of carbohydrate metabolism were defined with fasting glucose level and in 2 hours after load of75 g of glucose. CVR was assessed by SCORE. Risk of DM was checked by FINDRISC.

Results. Early disorders of glucose metabolism were found as high fasting glycaemia (HFG), glucose intolerance (GI) and their comorbidity. In 28,3% of men there was HFG, its comorbidity with GI was found only in 12,3%. In the group of men with lower and moderate CVR prediabetes was diagnosed in 21% cases. Among high CVR persons by SCORE the prediabetes was found in 40% cases, and in the group of not very high risk almost in every second had HFG, and concomitance of HFG and GI — 15,2% cases. Among moderate CVR patients — every tenth, with high CVR every third, and in the group with very high CVR — every second had severe risk of DM development by FINDRISC.

Conclusion. Тhence the increase of CVR is associated with foretime increase of DM risk. In the groups of high and very high CVR the HFG was most common, but concomitance of HFG with GI two times less common. The results obtained might be applied in the development of algorithms of correction of comorbidities in primary healthcare.