FACTOR ANALYSIS AND INDIVIDUAL PROGNOSIS FOR THE PATIENTS WITH FIRST REVEALED ARTERIAL HYPERTENSION

Aim. To conduct a comparative research of a variety of angiographic scales with the aim to choose strict and useful scoring system for coronary artery lesion estimation. Material and methods. The cohort of patients is investigated with the age of 25-86 y. (n=502, 70,7% males), who at FSBI "SSRCPM" of the Ministry of Health were underwent coronary arteriography. To evaluate the severity of atherosclerosis by the angiography results the scoring systems Gensisni and SYNTAX were used. Quantitative evaluation of stenoses was done using the software of "General Electric Innova 4100".

Results. The groups were formed acorrding to absence, mild or severe coronary atherosclerosis using the Gensini and SYNTAX scores, and also by coronary stenoses prominence. The significant association between all three methods was shown: Spearman correlation coefficient about 0,87. Quantity of points by Gensini and SYNTAX increases according to the quantity of arteries involved. But usage of Gensini score with addition of cut-off points makes more precise the identification of patients with severe coronary arteries lesion.

Conclusion. The Gensini scale and the cut-off points provided makes it possible a relevant estimation of coronary arteries lesion and improves the decision whether to revascularize or not.

1. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics-2011 update: a report from the American Heart Association. Circulation, 2011; 123: e18-e209.

2. Graham MM, Faris PD, Ghali WA, et al. Validation of three myocardial jeopardy scores in a population-based cardiac catheterization cohort. Am Heart J 2001; 142: 254-61.

3. Ringqvist I, Fisher LD, Mock M, et al. Prognostic value of angiographic indices of coronary artery disease from the Coronary Artery Surgery Study (CASS). J Clin Invest., 1983; 71 (6): 1854-66.

4. Gensini G. A more meaningful scoring system for determining the severity of coronary artery disease. Am J Cardiol, 1983; 51: 606.

5. Neeland IJ, Patel RS, Eshtehardi P, et al. Coronary angiographic scoring systems: An evaluation of their equivalence and validity. Am Heart J, 2012; 164: 547-52.

6. Sianos G, Morel M-A, Kappetein AP, et al. The syntax score: An angiographic tool grading the complexity of coronary artery disease. EuroInterv. 2005; 1: 219-27.

7. Kim YH, Park DW, Kim WJ, et al. Validation of SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) score for prediction of outcomes after unprotected left main coronary revascularization. J Am Coll Cardiol Intv, 2010; 3: 612-23.

8. Nicholls SJ, Tuzcu EM, Crowe T, et al. Relationship between cardiovascular risk factors and atherosclerotic disease burden measured by intravascular ultrasound. J Am Coll Cardiol 2006;47:1967-75.

9. Williams DO, Baim DS, Bates E, et al. Coronary anatomic and procedural characteristics of patients randomized to coronary angioplasty in the Bypass Angioplasty Revascularization Investigation (BARI). Am J Cardiol 1995; 75: 27C-33C.

10. Ekici B, Erkan AF, Alhan A, et al. Is mean platelet volume associated with the angiographic severity of coronary artery disease? Kardiol Pol, 2013; 71 (8): 832-8.

11. Abali G, Akpinar O, Nisanoglu V, Ilgenli TF. Severity of coronary artery disease and echocardiographic parameters of ventricular diastolic function. Echocardioraphy, 2013 [Epub ahead of print].

12. Sinning C, Lillpopp L, Appelbaum S, et al. Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application.Clin Res Cardiol. 2013 Jul; 102 (7): 495-503.

13. Yavuz B, Kabakci G, Aksoy H, et al. Determining the relationship between metabolic syndrome score and angiographic severity of coronary artery disease. Int J Clin Pract, 2008; 62 (5): 717-22.

14. Ndrepepa G, Tada T, Fusaro M, et al. Association of coronary atherosclerosis burden with clinical presentation and prognosis in patients with stable and unstable coronary artery disease. Clin Res Cardiol, 2012; 101 (12): 1003-11.