SOCIO-ECONOMIC RISK FACTORS FOR CARDIOVASCULAR DEATH: DATA FROM 12-YEAR PROSPECTIVE EPIDEMIOLOGIC STUDY

Aim. Studying of the influence of socio-economic risk factors on relative risk (RR) of death from cardiovascular diseases (CVD) in non-organized population of Tyumen city. Material and methods. The epidemiological study was performed with standard approaches on relevant selection of Tyumen citizens aged 25-64 y. During next 12 years the whole cohort (795 men, 814 women) was analyzed for the deaths from cardiovascular diseases (CVD). Multivariate regression model of proportional Kox risk used to estimate RR for cardiovascular death. RR with 95% CI calculated with added concomitant RF like: age, SBP and DBP, BMI, total cholesterol, triglycerides, HDL, smoking state, coronary heart disease anamnesis and arterial hypertension.

Results. By 12 years of observation there were 85 (10,7%) cases of cardiovascular death in men and 33 (4,1%) in women. Higher risk of cardiovascular death was in men with low educational level than in those with higher education (RR: 1,94, 95% CI 1,12-3,34). In women the same (RR: 3,42, 95% CI 1,53-7,64) in comparison to more educated women. After standartization of all concomitant factors the risk of cardiovascular death was significantly higher in men and women involved in hard physical labour (RR: 2,51, 95% CI 1,03-6,08 and 5,47, 95% CI 1,69-17,74, resp.), comparing to those of higher labour qualification (RR: 4,08 (95% CI 2,12-7,8), RR 3,19 (95% CI 1,22-8,34) and RR 3,18 (95% CI 1,90-5,34), resp. In women the relation was opposite: RR for cardiovascular death was higher for married women (3,21, 95% CI 1,28-8,06; p<0,001), than for single.

Conclusion. The highest risk for cardiovascular death in non-organized Tyumen citizen cohort was found for those with lower educational level, involved into hard physical labour and single, divorced or widowed men. In women, opposite, being married was associated with higher risk of death from CVD.

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