OBESITY AS A RISK FACTOR FOR CHRONIC NON-COMMUNICABLE DISEASES
https://doi.org/10.15829/1560-4071-2016-6-73-79
Abstract
Among the risk factors of years of life loss, with correction for disability, the leading are arterial hypertension, smoking, high body mass index. Results of large prospective studies confirm the relation of excessive body mass with the increase of cardiovascular risk. Relative risk of cardiovascular disorders (CVD) in obese is comparable to the total impact of BP raise by 20 mmHg. However, most of current CV risk stratification models do not include obesity as one of the risk factors. There are several phenotypes of obesity. Presence of any leads to increased cardiovascular and diabetes (type 2, DM) risk. Metabolically healthy obesity comparing to the situation of comorbid obesity with metabolic syndrome is associated with lower DM risk, but cardiovascular risk is high equally in both obesity phenotypes. Hence, metabolically healthy obesity is not “benign” condition and demands the actions from us, interventions for loss of weight and strict control of modifiable risk factors.
About the Authors
O. M. Drapkina
National Research Center for Preventive Medicine, Moscow
Russian Federation
Russian Federation
S. O. Eliashevich
National Research Center for Preventive Medicine, Moscow
Russian Federation
Competing Interests: Лаборант-исследователь отдела фундаментальных и прикладных аспектов ожирения ения
Russian Federation
Competing Interests: Лаборант-исследователь отдела фундаментальных и прикладных аспектов ожирения ения
R. N. Shepel
National Research Center for Preventive Medicine, Moscow
Russian Federation
Russian Federation
References
1. ВОЗ (2013г). Глобальный план действий ВОЗ по профилактике неинфекционных заболеваний и борьбе с ними на 2013-2020 гг. (http://apps.who.int/gb/ebwha/pdf_files/WHA66/A66_R10-ru.pdf)
2. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 2000; 894: 1-253.
3. de Mutsert R, den Heijer M, Rabelink TJ, et al. The Netherlands Epidemiology of Obesity (NEO) study: study design and data collection. Eur J Epidemiol 2013; 28: 513-23.
4. Balanova IuA, Kontsevaia AV, Shal’nova SA, et al. Prevalence of behavioral risk factors for cardiovascular disease in the Russian population: Results of the ESSE-RF epidemiological study. Preventive medicine 2014; 5: 42-52. Russian (Баланова Ю.А., Концевая А.В., Шальнова С.А. и др. Распространенность поведенческих факторов риска сердечнососудистых заболеваний в российской популяции по результатам исследования ЭССЕ-РФ. Профилактическая медицина 2014; 5: 42-52).
5. McLellan F. Obesity rising to alarming levels around the world. Lancet 2002; 359: 12-4.
6. Drapkina OM, Сhaparkina SO. Correlation of metabolic syndrome, inflammation and endothelial dysfunction. Russian Medical News 2007; 3: 67-76. Russian (Драпкина О.М., Чапаркина С.О. Взаимосвязь метаболического синдрома, асептического воспаления и дисфункции эндотелия. Российские медицинские вести 2007; 3: 67-76).
7. Lee Y. Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis. Journal of Clinical Epidemiology 2008; 61: 646-53.
8. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005; 365: 1415-28.
9. Meigs JB, Wilson PW, Fox CS, et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 2006; 91: 2906-12.
10. Finucane MM, Stevens GA. National, regional, and global trends in body mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 2011; 377: 557-67.
11. Cooney MT, Dudina A, D’Agostino R, et al. Cardiovascular risk estimation systems in primary prevention: do they differ? Do they make a difference? Can we see the future? Circulation 2010; 122: 300-10.
12. Ajani UA. Has the risk for coronary heart disease changed among U.S. adults? J. Am. Coll. Cardiol 2006; 48: 1177-82.
13. Akosah KO. Preventing myocardial infarction in the young adult in the first place: how do the National Cholesterol Education Panel III guidelines perform? J. Am. Coll. Cardiol. 2003; 41(9); 1475-9.
14. Berger JS, Jordan CO, Lloyd-Jones D, et al. Screening for Cardiovascular Risk in Asymptomatic Patients. J Am Coll Cardiol 2010; 55: 1169-77.
15. Hippisley-Cox J, Coupland C, Vinogradova Y, et al. Performance of the QRISK cardiovascular risk prediction algorithm in an independent UK sample of patients from general practice: a validation study. Heart 2008; 94: 34-9.
16. Meigs JB, Wilson PW, Fox CS, et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 2006; 91: 2906-12.
17. Caccamese SM, Kolodner K, Wright SM. Comparing patient and physician perception of weight status with body mass index. Am J Med 2002; 112: 662-6.
18. Goh L, Dhaliwal S, Welborn T, et al. 2014. Anthropometric measurements of general and central obesity and the prediction of cardiovascular disease risk in women: a crosssectional study. BMJ. 4 (2): Articel ID 004138.
19. Kyriakos Dimitriadis, Waist circumference compared with other obesity parameters as determinants of coronary artery disease in essential hypertension: a 6-year follow-up study. Hypertension Research 2016; 2: 1-5.
20. Sharma S. Normal-Weight Central Obesity and Mortality Risk in Older Adults With Coronary Artery Disease. Mayo Clin Proc. 2016; 4: 1-9.
21. Pencina MJ, D’AgostinoSr RB, D’Agostino Jr RB, et al. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med 2008; 27: 157-72.
22. Krintus M. Critical appraisal of inflammatory markers in cardiovascular risk stratification. Crit Rev Clin Lab Sci, Early Online: 9 June 2014.
23. van Dis I, Kromhout D, Geleijnse JM, et al. Paternal and maternal history of myocardial infarction and 10-year cardiovascular diseases incidence in a Dutch cohort of middle-aged men and women. PLoS One 2011; 6: 28-39.
24. Hinnouhо G-M, Metabolically healthy obesity and the risk of cardiovascular disease and type 2 diabetes: the Whitehall II cohort study. European Heart Journal Advance Access published March 26, 2014.
25. de Boer AW. Overweight can be used as a tool to guide case-finding for cardiovascular risk assessment. Family Practice, 2015; 32(6): 646-51.
26. Sims EA. Are there persons who are obese, but metabolically healthy? Metabolism 2011; 50: 1499-504.
27. Wildman RP. Body Size Phenotypes and Inflammation in the Women’s Health Initiative Observational Study. Obesity (2011) doi:10.1038/oby.2010.332
28. Bluher M. The distinction of metabolically ‘healthy’ from ‘unhealthy’ obese individuals. Curr Opin Lipidol 2010; 21: 38-43.
29. Wildman RP, Muntner P, Reynolds K, et al. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med 2008; 168: 1617-24.
30. Pajunen P. Metabolically healthy and unhealthy obesity phenotypes in the general population: the FIN-D2D Survey. BMC Public Health 2011, 11: 754.
31. Khana I, et al. Burden of subclinical cardiovascular disease in “metabolically benign” and “at-risk” overweight and obese women: The Study of Women’s Health Across the Nation (SWAN), Atherosclerosis 2011; 217: 179-86.
32. Drapkina OM, Shepel’ RN. Low sodium diet: pros and cons. Ration Pharmacother Cardiol 2015; 11(2): 190-5. Russian (Драпкина О.М., Шепель Р.Н. Диета с низким содержанием поваренной соли: за и против. Рациональная фармакотерапия в кардиологии. 2015; 11(2): 190-5.
Review
For citations:
Drapkina O.M., Eliashevich S.O., Shepel R.N. OBESITY AS A RISK FACTOR FOR CHRONIC NON-COMMUNICABLE DISEASES. Russian Journal of Cardiology. 2016;(6):73-79. (In Russ.) https://doi.org/10.15829/1560-4071-2016-6-73-79
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