LONG TERM CLINICAL RESULTS OF AUTOLOGOUS CD133+ BONE MARROW CELLS TRANSPLANTATION IN ST ELEVATION MYOCARDIAL INFARCTION PATIENTS
https://doi.org/10.15829/1560-4071-2016-3-80-86
Abstract
Aim. To study the long-term effectiveness and safety of CD133+ bone marrow cells transplantation in ST elevation myocardial infarction (STEMI) patients.
Material and methods. To the open-label, randomized study we included 26 patients, admitted with primary MI during years 2006-2007 to SRI of Cardiology. Patients were randomized to two groups: 1st — stenting of infarction-related coronary artery (IRA) and transplantation of CD133+ bone marrow cells (n=10), 2nd — only stenting of IRA (n=16). Baseline clinical and anamnestic parameters were similar. In 7,70±0,42 years after MI we performed control investigation, that included physical examination, 6-minute walking test (6WT), echocardiography.
Results. It is found, that in the 1st group comparing to the 2nd, total and cardiovasular mortality was lower (20% (2) vs 44% (7), p=0,11; 22% (2) vs 25% (4), p=0,58, resp.). In the 2nd there were 7 cases of recurrent MI (44% of patients), 4 of those were fatal, but in the 1st group there were no any recurrent MI (p=0,01). During the whole followup, unstable angina was more common in the 2nd group (11 (69%) vs 2 (20%) in 1st, р=0,04). CHF of II FC and higher was more common in 2nd group: 8 (50%) vs 2 (20%) in 1st, р=0,07. Also, there were significant differences in analysis of volumetrics of the left ventricle (EDV — 100,7±50,2 mL vs 144,4±42,7 mL, р=0,049; ESV — 56,3±37,8 mL vs 89,7±38,7 mL, р=0,049, resp.). These values were lower in the 1st group.
Conclusion. The results demonstrated that transplantation of autologous CD133+ bone marrow cells positively influences long-term survival of patients, CHD course and volumetric LV parameters.
About the Authors
M. A. Kirgizova
Scientific-Research Institute of Cardiology
Russian Federation
Tomsk
Russian Federation
Tomsk
V. V. Ryabov
Scientific-Research Institute of Cardiology;
Siberian State Medical University of the Ministry of Health;
National Research Tomsk State University
Russian Federation
Tomsk
Russian Federation
Tomsk
T. E. Suslova
Scientific-Research Institute of Cardiology;
National Research Tomsk State University
Russian Federation
Tomsk
Russian Federation
Tomsk
M. A. Shtatolkina
Scientific-Research Institute of Cardiology
Russian Federation
Tomsk
Russian Federation
Tomsk
V. A. Markov
Scientific-Research Institute of Cardiology;
Siberian State Medical University of the Ministry of Health
Russian Federation
Tomsk
Russian Federation
Tomsk
R. S. Karpov
Scientific-Research Institute of Cardiology;
Siberian State Medical University of the Ministry of Health
Russian Federation
Tomsk
Russian Federation
Tomsk
References
1. Sürder D, Manka R, Lo Cicero V, et al. Intracoronary injection of bone marrow derived mononuclear cells, early or late after acute myocardial infarction: effects on global left ventricular function. Circulation 2013; 127: 1968-79.
2. Bokeria LA, Goluhova EZ, Kakuchaya TT, et al. New horizons application of stem cell technologies to treat patients with chronic heart failure. Creative Cardiology 2009; 2: 33-47. Russian (Бокерия Л.А., Голухова Е.З., Какучая Т.Т. и др. Новые горизонты применения клеточных технологий для лечения пациентов с хронической сердечной недостаточностью. Креативная кардиология 2009; 2: 33-47).
3. Puymirat E, Geha R, Tomescot A, et al. Can mesenchymal stem cells induce tolerance to cotransplanted human embryonic stem cells? Mol. Ther. 2009; 17: 176-82.
4. Surder D, Manka R, Lo Cicero V, et al. Intracoronary injection of bone marrow derived mononuclear cells, early or late after acute myocardial infarction: effects on global left ventricular function four months results of the SWISS-AMI trial. Circulation 2013; 127: 1968-79.
5. Turan RG, Bozdag T, Turan CH, et al. Enhanced mobilization of the bone marrowderived circulating progenitor cells by intracoronary freshly isolated bone marrow cells transplantation in patients with acute myocardial infarction. J Cell Mol Med. 2012; 16: 852-64.
6. Clifford MD, Fisher SA, Brunskill SJ, et al. Long-term effects of autologous bone marrow stem cell treatment in acute myocardial infarction: factors that may influence outcomes. PLoS ONE. — URL: www.plosone.org. 2012; 7, 5: 1-9.
7. Gyöngyösi M, Wojakowski W, Lemarchand P, et al. Meta-analysis of cell-based cardiac studies (ACCRUE) in patients with acute myocardial infarction based on individual patient data. Circ Res. 2015; 116: 1346-60. doi: 10.1161/CIRCRESAHA.116.304346.
8. Karpov RS, Ryabov VV, Suslova TE, et al. The results of the six-month follow-up after transplantation of autologous bone marrow mononuclear cells to patients with acute primary transmural myocardial infarction. Creative cardiology 2007; 1-2: 200-8. Russian (Карпов Р.С., Рябов В.В., Суслова Т.Е. и др. Результаты шестимесячного наблюдения после трансплантации аутологичных мононуклеарных клеток костного мозга больным c острым первичным трансмуральным инфарктом миокарда. Креативная кардиология 2007; 1-2: 200-8).
9. Shtatolkina MA, Ryabov VV, Suslova TE, et al. Circulating bone marrow stem cells: dynamic and values in acute myocardial infarction. Sib. Med. J. 2010; 25: 45-52. Russian (Штатолкина M.A., Рябов В.В., Суслова T.E. и др. Циркулирующие в крови стволовые клетки: динамика и значение при остром инфаркте миокарда. Сибирский медицинский журнал 2010; 25: 45-52).
10. Mansour S, Roy D-C, Bouchard V, et al. One-Year Safety Analysis of the COMPARE-AMI Trial: Comparison of Intracoronary Injection of CD133+ Bone Marrow Stem Cells to Placebo in Patients after Acute Myocardial Infarction and Left Ventricular Dysfunction. Bone Marrow Research 2011; Article ID 385124.
11. Pavon LF, Gamarra LF, Marti LC, et al. Ultrastructural characterization of CD133+ stem cells bound to superparamagnetic nanoparticles: possible biotechnological applications. Journal of Microscopy 2008, 231, 3: 374-383.
12. Ryabov VV, Kirgizova MА, Suslova TE, et al. Long-term clinical results of autologous bone marrow mononuclear cell transplantation in patients with acute myocardial infarction. Sib. Med. J. 2014; 29: 30-37. Russian (Рябов В.В., Киргизова М. А., Суслова Т.Е. и др. Отдаленные клинические результаты трансплантации аутологичных мононуклеарных клеток костного мозга больным острым инфарктом миокардом. Сибирский медицинский журнал 2014; 29: 30-37).
13. Delewi R, Hirsch A, Tijssen JG, et al. Impact of intracoronary bone marrow cell therapy on left ventricular function in the setting of ST-segment elevation myocardial infarction: a collaborative meta-analysis. Eur Heart J. 2014; 35: 989-98. doi: 10.1093/eurheartj/eht372.
14. Chachques JC, Herreros J, Trainini J, et al. Autologous human serum for cell culture avoids the implantation of cardioverter-debrillators in cellular cardiomyoplasty. Int. J. Cardiol 2005; 95: 29-33.
Review
For citations:
Kirgizova M.A., Ryabov V.V., Suslova T.E., Shtatolkina M.A., Markov V.A., Karpov R.S. LONG TERM CLINICAL RESULTS OF AUTOLOGOUS CD133+ BONE MARROW CELLS TRANSPLANTATION IN ST ELEVATION MYOCARDIAL INFARCTION PATIENTS. Russian Journal of Cardiology. 2016;(3):80-86. (In Russ.) https://doi.org/10.15829/1560-4071-2016-3-80-86
Views:
833
Email this article 