Preview

Russian Journal of Cardiology

Advanced search

Prehospital intraosseous administration of a fibrinolytic agent in a patient with ST-elevation acute coronary syndrome: a case report

https://doi.org/10.15829/1560-4071-2025-6664

EDN: UHOPXR

Abstract

The safety and efficacy of prehospital intraosseous administration of nonimmunogenic staphylokinase in a patient with ST-elevation acute coronary syndrome (STE-ACS) was clinically confirmed. A case of prehospital intraosseous thrombolytic therapy with non-immunogenic staphylokinase at a single bolus dose of 15 mg in a patient with STE-ACS is described. Intraosseous administration is a rapid and reliable emergency, which can be used, among other things, for thrombolytic therapy.

About the Authors

I. G. Trukhanova
Samara State Medical University
Russian Federation

Chapaevskaya St., 89, Samara, 443099



D. S. Zinatullina
Samara State Medical University

Chapaevskaya St., 89, Samara, 443099



I. A. Polyakov
Samara State Medical University; Tolyatti Emergency Medical Setting

Chapaevskaya St., 89, Samara, 443099; 

Zhilina St., 29, Tolyatti



G. F. Ismailova
Tolyatti Emergency Medical Setting

Zhilina St., 29, Tolyatti



S. Kh. Sadreeva
Samara State Medical University

Chapaevskaya St., 89, Samara, 443099



References

1. Koguashvili GE, Ganieva LB, Berdnikova AV, et al. Experience of using intraosseous access in a multidisciplinary hospital (Children’s Republican Clinical Hospital of Kazan, Ministry of Health of the Republic of Tatarstan). Emergency medical care. 2022;23(2):44-51. (In Russ.) doi:10.24884/2072-6716-2022-23-2-44-51.

2. Oleynikov VE, Shakhnovich RM, Yakovlev AN, et al. Prospects for a pharmacoinvasive strategy in ST-elevation myocardial infarction in the Russian Federation. Russian Journal of Cardiology. 2025;30(3):6290. (In Russ.) doi:10.15829/1560-4071-2025-6290. EDN: FPPJBP.

3. Tereshchenko SN, Duplyakov DV, Uskach TM, et al. Potential of thrombolytic therapy in the early period of ST-elevation myocardial infarction. Expert consensus. Russian Journal of Cardiology. 2025;30(6):6417. (In Russ.) doi:10.15829/15604071-2025-6417.

4. Sou V, McManus C, Mifflin N, et al. A clinical pathway for the management of difficult venous access. BMC Nurs. 2017;16:64. doi:10.1186/s12912-017-0261-z.

5. Kuensting LL, DeBoer S, Holleran R, et al. Difficult venous access in children: taking control. J Emerg Nurs. 2009;35(5):419-24. doi:10.1016/j.jen.2009.01.014.

6. Zhirov AV, Minnullin IP, Radushkevich VL, et al. Prospects for the use of intraosseous vascular access in emergency medical care in emergency situations and military conflicts. Emergency medical care. 2024;25(3):34-9. (In Russ.) doi:10.24884/2072-6716-2024-25-3-34-39.

7. Markov VA, Duplyakov DV, Konstantinov SL, et al. Fortelyzin® versus Metalyse® in ST-segment elevation myocardial infarction: results of multicenter randomized trial FRIDOM 1. Kardiologicheskyi vestnik. 2017;12(3):52-9. (In Russ.)

8. Markov VA, Duplyakov DV, Konstantinov SL, et al. Fortelyzin® in comparison with Metalyse® for ST-elevated myocardial infarction: one-year results and clinical outcomes of a multicenter randomized study FRIDOM1. Russian Journal of Cardiology. 2018;(11):110-6. (In Russ.) doi:10.15829/1560-4071-2018-11-110-116.

9. Tereshchenko SN, Bagnenko SF, Markov VA, et al. Safety of prehospital thrombolysis with non-immunogenic staphylokinase in 51021 patients with ST-elevation myocardial infarction: data from the FRIDOM-registry. Russian Journal of Cardiology. 2025;30(6):6355. (In Russ.) doi:10.15829/1560-4071-2025-6355.

10. Tereshchenko SN, Bagnenko SF, Yakovlev AN, et al. Safety and efficacy of non-immunogenic staphylokinase in elderly patients over 75 years old with ST-segment elevation myocardial infarction: FREEDOM registry data. Russian Journal of Cardiology. 2025;30(8):6487. (In Russ.) Тdoi:10.15829/15604071-2025-6487.

11. Markin SS, Ivanov SV, Beletsky IP, et al. Assessment of the allergenic and immunotoxic properties of the recombinant non-immunogenic staphylokinase in preclinical and clinical trials. Pharmacy & Pharmacology. 2025;13(1):31-44. (In Russ.) doi:10.19163/2307-92662025-13-1-31-44.

12. Ivanov SV, Beletsky IP, Zakharova MV, et al. Study of the pharmacokinetics of non-immunogenic staphylokinase in patients with acute myocardial infarction and acute ischemic stroke. Pharmacy & Pharmacology. 2025;13(5):415-28. (In Russ.) doi:10.19163/2307-9266-2025-13-5-415-428.

13. Davydov VV, Tretyakova EM. Intraosseus access by ambulance. Emergency medical care. 2021;22(1):13-9. (In Russ.) doi:10.24884/2072-6716-2021-22-1-13-19.


Review

For citations:


Trukhanova I.G., Zinatullina D.S., Polyakov I.A., Ismailova G.F., Sadreeva S.Kh. Prehospital intraosseous administration of a fibrinolytic agent in a patient with ST-elevation acute coronary syndrome: a case report. Russian Journal of Cardiology. 2025;30(12):6664. (In Russ.) https://doi.org/10.15829/1560-4071-2025-6664. EDN: UHOPXR

Views: 52

JATS XML


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1560-4071 (Print)
ISSN 2618-7620 (Online)