Treatment of hypertensive patients in Russian real-world practice based on the data from 2025 blood pressure measurement campaign
O. P. Rotar,
E. V. Moguchaya,
M. A. Boyarinova,
O. A. Rubanenko,
E. Yu. Gubareva,
O. E. Gaberman,
N. Yu. Shimokhina,
S. Yu. Shtarik,
L. K. Danilova,
A. A. Evsyukov,
E. V. Zorina,
Ya. A. Pomazkina,
L. E. Tepnadze,
E. A. Pronina,
T. G. Zakharova,
M. M. Petrova,
D. S. Kaskaeva,
E. A. Tepper,
E. V. Galko,
I. V. Avdeeva,
L. I. Salyamova,
A. Yu. Falkovskaya,
M. A. Manukyan,
E. S. Nikolenko,
E. A. Stolbova,
A. K. Nagovitsin,
A. S. Pyleva,
Yu. A. Sharapova,
T. M. Chernykh,
O. V. Filyushin,
N. A. Koryagina,
V. S. Koryagin,
K. V. Protasov,
O. V. Fedorishina,
E. R. Makeeva,
E. V. Efremova,
A. A. Valiullina,
R. Z. Khaibulina,
T. S. Perepelkina,
A. S. Svishcheva,
E. Yu. Nasyrova,
S. B. Domogatsky,
O. V. Tsygankova,
O. V. Timoschenko,
A. I. Kiselev,
G. T. Akhmedpashaev,
K. T. Kitalaeva,
V. S. Chulkov,
E. A. Smirnova,
Y. A. Belenikina,
I. V. Bikushova,
E. A. Prodius,
I. Yu. Chernenko,
I. V. Tishchenko,
T. I. Yakunchenko,
D. V. Mevsha,
E. Yu. Gorozhankina,
N. V. Troshina,
E. A. Kartashova,
E. I. Zheleznyak,
V. M. Tsareva,
M. V. Derevyanchenko,
I. M. Makhova,
A. S. Strelko,
A. A. Chernova,
S. Yu. Nikulina,
A. A. Polyutova,
N. N. Artemov,
A. A. Tanicheva,
A. O. Konradi,
E. V. Shlyakhto https://doi.org/10.15829/1560-4071-2025-6490
EDN: PPSBMQ
Abstract
Aim. To evaluate the features of antihypertensive therapy (AHT), adherence to therapy and achievement of target blood pressure (BP) in patients with hypertension (HTN) in Russian real-world practice after the implementation of 2024 Russian clinical guidelines on hypertension in adults.
Material and methods. During May 2025, 7990 patients with HTN from 19 Russian cities and Tiraspol (Pridnestrovian Moldavian Republic) took part in the BP measurement campaign. Outpatients with HTN over the age of 18 voluntarily participated in the campaign. During the screening, BP and pulse were measured three times using an automatic or mechanical BP monitor. In addition, a questionnaire was filled out on behavioral risk factors, BP self-monitoring skills, medication adherence, AHT, comorbidities and related therapy. The effectiveness of AHT was understood as achieving the target BP level <140/90 mm Hg in patients with HTN and taking AHT, and BP control — in all hypertensive patients, regardless of taking AHT.
Results. The analysis included 7972 respondents aged 18 to 96 years (median age 62 years [51;71]), including 3372 men (42,3%). Among the participants, 74,4% took AHT, while 62,6% achieved target BP <140/90 mm Hg and 25,8% — target BP <130/80 mm Hg. On-demand therapy remains the leading reason for not taking AHT among patients with HTN. Approximately half of the participants (57,7%) answered that they do not use medication reminder systems. Most often, hypertensive patients use BP self-monitoring diaries and pill boxes. Every fifth patient with HTN was registered as taking antihypertensive monotherapy, every third as dual AHT, and every fourth as triple AHT. Single-pill combinations were taken by 34,5% of patients. In outpatient practice, following sex differences were revealed: significantly higher prevalence of taking AHT, using AHT reminder systems, discussions with a doctor, and the effectiveness of treatment and control of HTN were characteristic of female patients. Discussion with a doctor about the importance of following recommendations was associated with a significantly higher achievement of target BP level (odds ratio (OR) 1,43), the use of a single-pill AHT combination (OR 1,3) and statin therapy (OR 1,39), p<0,0001.
Conclusion. In outpatient practice after the implementation of 2024 Russian clinical guidelines for HTN, an increase in the coverage and efficacy of AHT, and the HTN control is observed compared to the population data of 2020-2022. AHT prescription profile indicates a decrease in the share of monotherapy and an increase in the share of triple combination. The use of single-pill antihypertensive combinations is growing, but remains insufficient. The results obtained demonstrate the importance of discussing with a physician the need to comply with recommendations in hypertensive patients to improve adherence and treatment effectiveness.
Keywords
hypertension,
blood pressure,
adherence,
antihypertensive therapy,
single-pill combinations,
clinical guidelines
Supporting agencies: The study was supported by the Russian Science Foundation, grant № 25-75-30010 (Agreement № 25-75-30010 dated May 22, 2025)
About the Authors
O. P. Rotar
Almazov National Medical Research Center
Russian Federation
Russian Federation
Saint Petersburg
E. V. Moguchaya
Almazov National Medical Research Center
Russian Federation
Russian Federation
Saint Petersburg
M. A. Boyarinova
Almazov National Medical Research Center
Russian Federation
Russian Federation
Saint Petersburg
O. A. Rubanenko
Samara State Medical University
Russian Federation
Russian Federation
Samara
E. Yu. Gubareva
Samara State Medical University
Russian Federation
Russian Federation
Samara
O. E. Gaberman
Samara State Medical University;
Russian Railways-Medicine Clinical Hospital
Russian Federation
Russian Federation
Samara
N. Yu. Shimokhina
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Natalya Yu. Shimokhina — Doctor of Medical Sciences, Professor of the Department of Outpatient Therapy and Family Medicine with a Course of Postgraduate Education
Krasnoyarsk
S. Yu. Shtarik
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Svetlana Yu. Shtarik — Doctor of Medical Sciences, Professor of the Department of Outpatient Therapy and Family Medicine with a Course of Postgraduate Education
Krasnoyarsk
L. K. Danilova
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Lyudmila K. Danilova — MD, PhD, Associate Professor at the Department of Outpatient Care and Family Medicine
Krasnoyarsk
A. A. Evsyukov
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Aleksandr A. Evsyukov — MD, PhD, Associate Professor at the Department of Outpatient Care and Family Medicine
Krasnoyarsk
E. V. Zorina
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Ekaterina V. Zorina — PhD, Associate Professor at the Department of Outpatient Care and Family Medicine
Krasnoyarsk
Ya. A. Pomazkina
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Yana A. Pomazkina — assistant at the Department of Outpatient Care and Family Medicine
Krasnoyarsk
L. E. Tepnadze
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Liia E. Tepnadze — MD, Therapist of the Department of General Medical Practice
Krasnoyarsk
E. A. Pronina
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Elena A. Pronina — Associate Professor Department of outpatient therapy and general practice with a PE-course
Krasnoyarsk
T. G. Zakharova
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Tatiana G. Zakharova — Professor, Doctor of Medical Science, Professor of the Department of Polyclinic Therapy, Family Medicine and Postgraduate Education Course
Krasnoyarsk
M. M. Petrova
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Мarina M. Petrova — MD, PhD, Doctor of Medical Sciences, Professor, Head of Department of outpatient therapy and general practice with a PE-course
Krasnoyarsk
D. S. Kaskaeva
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Darya S. Kaskaeva — MD, PhD, Associate Professor at the Department of Outpatient Care and Family Medicine
Krasnoyarsk
E. A. Tepper
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Elena A. Tepper — Doctor of Medical Sciences, Professor of the Department of Outpatient Therapy and Family Medicine with a Course of Postgraduate Education
Krasnoyarsk
E. V. Galko
Voyno-Yasenetsky Krasnoyarsk State Medical University;
Russian Federation
Russian Federation
Elena V. Galko — assistant at the Department of Outpatient Care and Family Medicine
Krasnoyarsk
I. V. Avdeeva
6Penza State University
Russian Federation
Russian Federation
Irina V. Avdeeva — MD, PhD, Assistant professor, Therapy Department
Penza
L. I. Salyamova
6Penza State University
Russian Federation
Russian Federation
Lyudmila I. Salyamova — Assistant professor, Therapy Department
Penza
A. Yu. Falkovskaya
Tomsk National Research Medical Center
Russian Federation
Russian Federation
Alla Yu. Falkovskaya — MD, PhD, Head of Department of Hypertension, Cardiology Research Institute
Tomsk
M. A. Manukyan
Tomsk National Research Medical Center, Tomsk
Russian Federation
Russian Federation
Musheg A. Manukyan — MD, Junior Researcher, Department of Hypertension, Cardiology Research Institute
Tomsk
E. S. Nikolenko
City Clinical Hospital № 11
Russian Federation
Russian Federation
Ekaterina S. Nikolenko — physician
Chelyabinsk
E. A. Stolbova
City Clinical Hospital № 11
Russian Federation
Russian Federation
Elizaveta A. Stolbova — the head of the health center, the general practitioner
Chelyabinsk
A. K. Nagovitsin
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
Aleksandr K. Nagovitsin — Physician at the Department of Hospital Therapy and Endocrinology, Teaching assistant at the Department of Clinical Laboratory Diagnostics of N.N. Burdenko
Voronezh
A. S. Pyleva
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
Anastasiya S. Pyleva — Student of the General Medicine Faculty
Voronezh
Yu. A. Sharapova
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
Yulia A. Sharapova — MD, PhD, Associate Professor of the Department of Hospital Therapy and Endocrinology
Voronezh
T. M. Chernykh
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
Tatyana M. Chernykh — MD, PhD, Professor, Head of the Department of Hospital Therapy and Endocrinology
Voronezh
O. V. Filyushin
Ryazan Region Regional Clinical Cardiology Dispensary
Russian Federation
Russian Federation
Oleg V. Filyushin — cardiologist
Ryazan
N. A. Koryagina
Wagner Perm State Medical University
Russian Federation
Russian Federation
Natalia A. Koryagina — PhD, Professor, Department of Outpatient Therapy
Perm
V. S. Koryagin
Wagner Perm State Medical University
Russian Federation
Russian Federation
Vladimir S. Koryagin — Chair of the Scientific Society of Young Researchers and Students
Perm
K. V. Protasov
Irkutsk State Medical Academy of Postgraduate Education — branch of the Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Konstantin V. Protasov — MD, PhD, Professor Head of Cardiology and Functional Diagnostic Dpt.
Irkutsk
O. V. Fedorishina
Irkutsk State Medical Academy of Postgraduate Education — branch of the Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Olga V. Fedorishina — MD, PhD, Associate Professor of Cardiology and Functional Diagnostic Department
Irkutsk
E. R. Makeeva
Ulyanovsk State University
Russian Federation
Russian Federation
Ekaterina R. Makeeva — MD, PhD, Associate Professor
Ulyanovsk
E. V. Efremova
Ulyanovsk State University
Russian Federation
Russian Federation
Elena V. Efremova — MD, PhD, Associate Professor, Professor of the Department of Therapy and Occupational Diseases
Ulyanovsk
A. A. Valiullina
Ulyanovsk State University, Ulyanovsk, Russia; 14Russian Railways-Medicine Hospital
Russian Federation
Russian Federation
Alina A. Valiullina — student of the Faculty of Medicine
Ulyanovsk
R. Z. Khaibulina
Ulyanovsk State University
Russian Federation
Russian Federation
Renata Z. Khaibulina — student of the Faculty of Medicine
Ulyanovsk
T. S. Perepelkina
Ulyanovsk State University
Russian Federation
Russian Federation
Tatyana S. Perepelkina — student of the Faculty of Medicine
Ulyanovsk
A. S. Svishcheva
Ulyanovsk State University
Russian Federation
Russian Federation
Anastasia S. Svishcheva — student of the medical faculty
Ulyanovsk
E. Yu. Nasyrova
Ulyanovsk State University;
Russian Railways-Medicine Hospital
Russian Federation
Russian Federation
Elena Yu. Nasyrova — PhD, Associate Professor of the Department of General and Clinical Pharmacology with a course in Microbiology
Ulyanovsk
S. B. Domogatsky
City Polyclinic № 21
Russian Federation
Russian Federation
Sergey B. Domogatsky — Cardiologist
St. Petersburg
O. V. Tsygankova
Novosibirsk State Medical University;Federal Research Center Institute of Cytology and Genetics
Russian Federation
Russian Federation
Oksana V. Tsygankova — MD, PhD, professor of Emergency Treatment, Endocrinological and Occupational Diseases Department, senior researcher of the Research Institutе of Internal and Preventive Medicine
Novosibirsk
O. V. Timoschenko
Federal Research Center Institute of Cytology and Genetics
Russian Federation
Russian Federation
Olga V. Timoschenko — PhD, Researcher of the Sector of Analytical and Methodological Problems of Therapeutic Diseases, Laboratory of Etiopathogenesis and Clinic of Internal Diseases, Research Institute of Internal and Preventive Medicine
Novosibirsk
A. I. Kiselev
Astrakhan State Medical University;
Federal Center of Cardiovascular Surgery
Russian Federation
Russian Federation
Aleksander I. Kiselev — resident physician at the Department of Cardiology, Faculty of Postgraduate Education, specialist of the Internal Quality Control Department
Astrakhan
G. T. Akhmedpashaev
Astrakhan State Medical University
Russian Federation
Russian Federation
Gadji T. Akhmedpashaev — resident physician at the Department of Cardiology, Faculty of Postgraduate Education
Astrakhan
K. T. Kitalaeva
Federal Center of Cardiovascular Surgery
Russian Federation
Russian Federation
Kamila T. Kitalaeva — Deputy chief physician for the organization of medical care
Astrakhan
V. S. Chulkov
Yaroslav the Wise Novgorod State University
Russian Federation
Russian Federation
Vasiliy S. Chulkov — MD, PhD, DSc, Professor, Department of Internal Diseases
Yaroslavl
E. A. Smirnova
Pavlov Ryazan State Medical University
Russian Federation
Russian Federation
Elena A. Smirnova — Head of the Department of Internal Medicine, Doctor of Medical Sciences, Associate Professor
Ryazan
Y. A. Belenikina
Pavlov Ryazan State Medical University
Russian Federation
Russian Federation
Yana A. Belenikina — MD, PhD, Associate Professor
Ryazan
I. V. Bikushova
Pavlov Ryazan State Medical University
Russian Federation
Russian Federation
Irina V. Bikushova — Assistant, Department of Internal Medicine
Ryazan
E. A. Prodius
Republican Clinical Hospital
Moldova, Republic of
Moldova, Republic of
Elena A. Prodius — Cardiologist
Tiraspol, Pridnestrovian
I. Yu. Chernenko
Republican Clinical Hospital
Moldova, Republic of
Moldova, Republic of
Irina Yu. Chernenko — Cardiologist
Tiraspol, Pridnestrovian
I. V. Tishchenko
Republican Clinical Hospital
Moldova, Republic of
Moldova, Republic of
Irina V. Tishchenko — Head of the Cardiology Department, Cardiologist
Tiraspol, Pridnestrovian
T. I. Yakunchenko
Belgorod State National Research University
Russian Federation
Russian Federation
Tatyana I. Yakunchenko — MD, professor, Head of Department of Internal Medicine Propedeutics and Clinical Information Technologies, Medical Institute
Belgorod
D. V. Mevsha
Belgorod State National Research University;
City Hospital № 2
Russian Federation
Russian Federation
Olga V. Mevsha — MD, PhD, associate professor of Department of Internal Medicine Propedeutics and Clinical Information Technologies, Medical institute
Belgorod
E. Yu. Gorozhankina
Feodosia Military Sanatorium
Russian Federation
Russian Federation
Evgenia Yu. Gorozhankina — Head of the Functional testing Department
Feodosia, Republic of Crimea
N. V. Troshina
Egorov Central Clinical Medical-Sanitary Unit
Russian Federation
Russian Federation
Natalia V. Troshina — Head of the cardiology department for patients with acute coronary syndrome
Ulyanovsk
E. A. Kartashova
Rostov State Medical University
Russian Federation
Russian Federation
Elena A. Kartashova — MD, PhD, Associate Professor of the Department of Internal Diseases No. 2
Rostov-on-Don
E. I. Zheleznyak
Rostov State Medical University
Russian Federation
Russian Federation
Elena I. Zheleznyak — MD, PhD, Assistant of the Department of Internal Medicine No. 2
Rostov-on-Don
V. M. Tsareva
Smolensk State Medical University
Russian Federation
Russian Federation
Valentina M. Tsareva — MD, PhD, Professor of the Department of Therapy, Ultrasound and Functional Diagnostics of the Continuing Professional Education Faculty
Smolensk
M. V. Derevyanchenko
Volgograd State Medical University
Russian Federation
Russian Federation
Maria V. Derevyanchenko — MD, PhD, Associate Professor, Professor of the Department of Internal Medicine of the Pediatric and Dental Faculties, General Practitioner of the Family Medicine Clinic
Volgograd
I. M. Makhova
Northern State Medical University
Russian Federation
Russian Federation
Irina M. Makhova — Resident Physician
Arkhangelsk
A. S. Strelko
Northern State Medical University
Russian Federation
Russian Federation
Alexandra S. Strelko — Resident Physician
Arkhangelsк
A. A. Chernova
Voyno-Yasenetsky Krasnoyarsk State Medical University;
Federal Siberian Research Clinical Center
Russian Federation
Russian Federation
Krasnoyarsk
S. Yu. Nikulina
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Krasnoyarsk
A. A. Polyutova
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Krasnoyarsk
N. N. Artemov
Almazov National Medical Research Center;
Nationwide Children’s Hospital
Russian Federation
Russian Federation
Nikita N. Artemov — MD, PhD, assistant professor Of Institute for Genomic Medicine
Saint Petersburg, Columbus, USA
A. A. Tanicheva
Russian Society of Cardiology
Russian Federation
Russian Federation
Anastasia A. Tanicheva — Executive Director
Moscow
A. O. Konradi
Almazov National Medical Research Center
Russian Federation
Russian Federation
Aleksandra A. Konradi — MD, PhD, Professor, Academician of the Russian Academy of Sciences, vice-director on scientific work
Saint Petersburg
E. V. Shlyakhto
Almazov National Medical Research Center
Russian Federation
Russian Federation
Evgeny V. Shlyakhto — MD, PhD, Professor, Academician of the Russian Academy of Sciences, General Director
Saint Petersburg
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Supplementary files
- The implementation of 2024 Russian guidelines on hypertension in adults in is associated with trends towards increasing the coverage of the population with antihypertensive therapy.
- A shift towards triple therapy, including single-pill combinations, was revealed.
- Interaction between physician and patient in the form of discussion of the need to comply with recommendations is an important factor associated with improved treatment adherence and effectiveness.
Review
For citations:
Rotar O.P., Moguchaya E.V., Boyarinova M.A., Rubanenko O.A., Gubareva E.Yu., Gaberman O.E., Shimokhina N.Yu., Shtarik S.Yu., Danilova L.K., Evsyukov A.A., Zorina E.V., Pomazkina Ya.A., Tepnadze L.E., Pronina E.A., Zakharova T.G., Petrova M.M., Kaskaeva D.S., Tepper E.A., Galko E.V., Avdeeva I.V., Salyamova L.I., Falkovskaya A.Yu., Manukyan M.A., Nikolenko E.S., Stolbova E.A., Nagovitsin A.K., Pyleva A.S., Sharapova Yu.A., Chernykh T.M., Filyushin O.V., Koryagina N.A., Koryagin V.S., Protasov K.V., Fedorishina O.V., Makeeva E.R., Efremova E.V., Valiullina A.A., Khaibulina R.Z., Perepelkina T.S., Svishcheva A.S., Nasyrova E.Yu., Domogatsky S.B., Tsygankova O.V., Timoschenko O.V., Kiselev A.I., Akhmedpashaev G.T., Kitalaeva K.T., Chulkov V.S., Smirnova E.A., Belenikina Y.A., Bikushova I.V., Prodius E.A., Chernenko I.Yu., Tishchenko I.V., Yakunchenko T.I., Mevsha D.V., Gorozhankina E.Yu., Troshina N.V., Kartashova E.A., Zheleznyak E.I., Tsareva V.M., Derevyanchenko M.V., Makhova I.M., Strelko A.S., Chernova A.A., Nikulina S.Yu., Polyutova A.A., Artemov N.N., Tanicheva A.A., Konradi A.O., Shlyakhto E.V. Treatment of hypertensive patients in Russian real-world practice based on the data from 2025 blood pressure measurement campaign. Russian Journal of Cardiology. 2025;30(9):6490. (In Russ.) https://doi.org/10.15829/1560-4071-2025-6490. EDN: PPSBMQ
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