Impact of patient genetic characteristics on myocardial contractility recovery during the outpatient rehabilitation after acute myocardial infarction

Aim. To study the impact of patients’ genetic characteristics on myocardial contractility recovery after acute myocardial infarction (AMI) during the outpatient rehabilitation using the elastic mapping.

Material and methods. The study included 127 patients (98 men and 29 women), aged 36 to 65 years, with a mean age of 59,0±8,7 years, who had an AMI. Three to six weeks after AMI, all patients underwent the third (outpatient) 14-day stage of rehabilitation. All patients also completed a course of cycling training. Before and after cycling, patients underwent cycle ergometry, a six-minute walk test, and a Borg Scale assessment. Recovery of myocardial contractility was assessed based on changes in these test parameters. All patients underwent genomic DNA extraction, and the following nucleotide sequence variants were analyzed: SCN5A rs1805126, LRRC31 rs16847897, AGTR1 rs5186, and ADRB2 rs1042714. Elastic maps were created using the ElMap software.

Results. An association was established between carriage of the GG genotype of SCN5A rs1805126 and impaired recovery of cardiac contractility. No association was found between carriage of the CC, CG, and GG genotypes of LRRC31 rs16847897 and impaired myocardial contractility recovery. Elastic map visualization made it possible to clearly differentiate patients with the GG, AA, and AG genotypes of SCN5A rs1805126 and to identify areas for further research on AGTR1 rs5186 and ADRB2 rs1042714. No significant differences were found between men and women.

Conclusion. Information on the association between carriage of these genotypes can be used for an individualized approach to exercise level selection during cycling training at the third (outpatient) rehabilitation stage in patients after AMI.

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