Predictors of acute left ventricular failure in patients with acute ST-segment elevation myocardial infarction
https://doi.org/10.15829/1560-4071-2026-6301
EDN: OAIHCZ
Abstract
Aim. To study predictors of acute left ventricular failure in patients with newly diagnosed acute ST-segment elevation myocardial infarction (STEMI) of the left ventricular (LV) anterior wall during hospitalization.
Material and methods. A total of 150 patients with newly diagnosed STEMI within the first 24 hours were included. The study was conducted in accordance with Good Clinical Practice and Declaration of Helsinki standards. The protocol was approved by the Ethics Committee. Study participants signed informed consent. Clinical and laboratory data, sST2 levels, and echocardiographic parameters were analyzed. The risk of in-hospital mortality was assessed using the GRACE score. Patients were divided into groups based on the severity of acute heart failure according to the T. Killip classification. Patient data were assessed during hospitalization and discharge. Statistical analysis was performed using Statistica 10.0 for Windows. Differences were considered significant at p<0,05.
Results. A patient profile was described with STEMI of the anterior LV wall complicated by acute left ventricular failure: mean age, 68,7 years; body mass index, 33,0 kg/m2; waist circumference, 94,56 cm; GRACE score, 208,22. Lipid metabolism disorders and elevated early markers of myocardial necrosis were identified regardless of acute heart failure severity. Over inpatient treatment of patients with Killip III-IV STEMI, we revealed an increase in sST2 during the first day of disease and a persistence of 2,2 times above normal at discharge. Echocardiographic features in patients with STEMI of the anterior LV wall are described.
Conclusion. Predicting acute left ventricular failure in patients with STEMI of the anterior LV wall during inpatient treatment will allow for timely modification of treatment strategies, which may subsequently impact prognosis.
About the Authors
E. V. Khorolets
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Nakhichevansky lane, 29, Rostov-on-Don
Competing Interests:
None
M. M. Mamedov
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Competing Interests:
Russian Federation
Petroverigsky Lane, 10, bld. 3, Moscow, 101990
Competing Interests:
None
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For citations:
Khorolets E.V., Mamedov M.M. Predictors of acute left ventricular failure in patients with acute ST-segment elevation myocardial infarction. Russian Journal of Cardiology. 2026;31(3):6301. (In Russ.) https://doi.org/10.15829/1560-4071-2026-6301. EDN: OAIHCZ
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