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Timing and pathogenesis of heart conduction disorders during transcatheter aortic valve implantation: data of intraoperative Holter monitoring

https://doi.org/10.15829/1560-4071-2025-6300

EDN: WJFZIA

Abstract

Aim. To evaluate the timing and relationship of heart conduction disorders with various surgical steps of transcatheter aortic valve implantation (TAVI) using intraoperative Holter monitoring.

Material and methods. This prospective observational study included 60 patients with high risk of atrioventricular (AV) conduction abnormalities who underwent TAVI for severe aortic stenosis. Intraoperative heart rhythm assessment was performed using continuous Holter monitoring. After the procedure, cardiac rhythm recording was continued for the next 24 h. The target time intervals of the main surgical steps were then compared with conduction disorders (transient and/or persistent) identified (first-degree AV block, complete AV block, right and left bundle branch blocks).

Results. Newly diagnosed conduction disorders were noted in 85,3% of patients. In 31,2% of patients, conduction disorders were noted before bioprosthetic valve implantation (positioning of guidewire, balloon valvuloplasty), in 23,4% — at the stage of bioprosthetic valve implantation, and in 31,5% — immediately after the balloon postdilation. The transient course was most characteristic of complete AV block, the resolution of which in the postoperative period was noted in 62,5% of cases. First-degree AV block and left bundle branch block persisted before discharge from the hospital in 71,4% and 65% of cases, respectively. Among transient cardiac conduction disturbances, first-degree AV block had the longest duration, the median time to resolution of which was 420 min.

Conclusion. About a third of heart conduction disorders in TAVI occur before bioprosthetic valve implantation. The most common heart conduction disorder after TAVI is new-onset complete left bundle branch block, which in most cases is persistent and remains until the patient is discharged from the hospital. Intraoperative heart rhythm monitoring after TAVI can be an important tool for assessing and predicting various heart conduction disorders, as well as determining the optimal postoperative patient management strategy.

About the Authors

A. A. Baranov
Meshalkin National Medical Research Center
Russian Federation

Novosibirsk



O. A. Bystritskaya
Meshalkin National Medical Research Center
Russian Federation

Novosibirsk



E. S. Zamaraeva
Meshalkin National Medical Research Center
Russian Federation

Novosibirsk



A. G. Badoyan
Meshalkin National Medical Research Center
Russian Federation

Novosibirsk



D. A. Khelimsky
Meshalkin National Medical Research Center
Russian Federation

Novosibirsk



A. Yu. Tsydenova
Meshalkin National Medical Research Center; Novosibirsk State Medical University
Russian Federation

Novosibirsk



I. S. Peregudov
Meshalkin National Medical Research Center
Russian Federation

Novosibirsk



A. G. Filippenko
Meshalkin National Medical Research Center
Russian Federation

Novosibirsk



M. A. Yusupova
Research Institute — Ochapovsky Regional Clinical Hospital № 1
Russian Federation

Krasnodar



S. V. Maingart
Research Institute — Ochapovsky Regional Clinical Hospital № 1
Russian Federation

Krasnodar



A. N. Fedorchenko
Research Institute — Ochapovsky Regional Clinical Hospital № 1
Russian Federation

Krasnodar



O. V. Krestyaninov
Meshalkin National Medical Research Center; Novosibirsk State Medical University
Russian Federation

Novosibirsk



References

1. Otto CM, Nishimura RA, Bonow RO, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2021;143(5):e35-e71. doi:10.1161/CIR.0000000000000932.

2. Alekyan BG, Ruchkin DV, Karapetyan NG, et al. Case report of a multidisciplinary approach to one-time treatment of a patient with critical aortic valve stenosis, lesion of the left main coronary artery and bleeding stomach cancer. Patologiya krovoobrashcheniya i kardiokhirurgiya = Circulation Pathology and Cardiac Surgery. 2022;26(2):58-65. (In Russ.) doi:10.21688/1681-3472-2022-2-58-65.

3. Fujita B, Schmidt T, Bleiziffer S, et al. Impact of new pacemaker implantation following surgical and transcatheter aortic valve replacement on 1-year outcome. Eur J Cardiothorac Surg. 2020;57(1):151-9. doi:10.1093/ejcts/ezz168.

4. Alekian BG, Titov NS. Endovascular treatment of aortic valve stenosis in combination with coronary artery disease: a systematic review. Patologiya krovoobrashcheniya i kardiokhirurgiya = Circulation Pathology and Cardiac Surgery. 2024;28(2):7-20. (In Russ.) doi:10.21688/1681-3472-2024-2-7-20.

5. Alperi Garcia A, Muntané-Carol G, Junquera L, et al. Can we reduce conduction disturbances following transcatheter aortic valve replacement? Expert Rev Med Devices. 2020;17(4):309-22. doi:10.1080/17434440.2020.1741349.

6. Nuche J, Ellenbogen KA, Mittal S, et al. Conduction Disturbances After Transcatheter Aortic Valve Replacement: An Update on Epidemiology, Preventive Strategies, and Management. JACC Cardiovasc Interv. 2024;17(22):2575-95. doi:10.1016/j.jcin.2024.07.032.

7. Zaid S, Sengupta A, Okoli K, et al. Novel Anatomic Predictors of New Persistent Left Bundle Branch Block After Evolut Transcatheter Aortic Valve Implantation. American Journal of Cardiology. 2020;125(8):1222-9. doi:10.1016/j.amjcard.2020.01.008.

8. Wendler O, Schymik G, Treede H, et al. SOURCE 3: 1-year outcomes post-transcatheter aortic valve implantation using the latest generation of the balloon-expandable transcatheter heart valve. European Heart Journal. 2017;38(36):2717-26. doi:10.1093/eurheartj/ehx294.

9. Faroux L, Chen S, Muntané-Carol G, et al. Clinical impact of conduction disturbances in transcatheter aortic valve replacement recipients: a systematic review and meta-analysis. Eur Heart J. 2020;41(29):2771-81. doi:10.1093/eurheartj/ehz924.

10. Sasaki K, Kuwata S, Izumo M, et al. Three-Year Clinical Impacts of Permanence, Resolution, and Absence of Newly-Developed Left Bundle Branch Block After Transcatheter Aortic Valve Replacement. Am J Cardiol. 2023;202:166-8. doi:10.1016/j.amjcard. 2023.06.092.

11. Piazza N, de Jaegere P, Schultz C, et al. Anatomy of the aortic valvar complex and its implications for transcatheter implantation of the aortic valve. Circ Cardiovasc Interv. 2008;1(1):74-81. doi:10.1161/CIRCINTERVENTIONS.108.780858.

12. Cabrera JÁ, Anderson RH, Porta-Sánchez A, et al. The Atrioventricular Conduction Axis and its Implications for Permanent Pacing. Arrhythm Electrophysiol Rev. 2021;10(3): 181-9. doi:10.15420/aer.2021.32.

13. Vahanian A, Beyersdorf F, Praz F, et al. ESC/EACTS Scientific Document Group. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2021;43(7):561-632. doi:10.1093/eurheartj/ehab395.

14. Surawicz B, Childers R, Deal BJ, et al. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part III: intraventricular conduction disturbances: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology. J Am Coll Cardiol. 2009;53:976-81. doi:10.1016/j.jacc.2008.12.013.

15. Mahajan S, Gupta R, Malik AH, et al. Predictors of permanent pacemaker insertion after TAVR: a systematic review and updated meta-analysis. J Cardiovasc Electrophysiol. 2021;32(5):1411-20. doi:10.1111/jce.14986.

16. Ravaux JM, Van Kuijk SMJ, Di Mauro M, et al. Incidence and predictors of permanent pacemaker implantation after transcatheter aortic valve procedures: data of the Netherlands Heart Registration (NHR). J Clin Med. 2022;11(3):560. doi:10.3390/jcm11030560.

17. Campelo-Parada F, Nombela-Franco L, Urena M, et al. Timing of Onset and Outcome of New Conduction Abnormalities Following Transcatheter Aortic Valve Implantation: Role of Balloon Aortic Valvuloplasty. Rev Esp Cardiol (Engl Ed). 2018;71(3):162-9. English, Spanish. doi:10.1016/j.rec.2017.04.010.

18. Nuis RJ, Van Mieghem NM, Schultz CJ, et al. Timing and potential mechanisms of new conduction abnormalities during the implantation of the Medtronic CoreValve System in patients with aortic stenosis. Eur Heart J. 2011;32(16):2067-74. doi:10.1093/eurheartj/ehr110.

19. Rubín JM, Avanzas P, del Valle R, et al. Atrioventricular conduction disturbance characterization in transcatheter aortic valve implantation with the CoreValve prosthesis. Circ Cardiovasc Interv. 2011;4(3):280-6. doi:10.1161/CIRCINTERVENTIONS.111.961649.

20. Laynez A, Ben-Dor I, Hauville C, et al. Frequency of cardiac conduction disturbances after balloon aortic valvuloplasty. Am J Cardiol. 2011;108(9):1311-5. doi:10.1016/j.amjcard.2011.06.049.

21. Bernardi FL, Ribeiro HB, Carvalho LA, et al. Direct Transcatheter Heart Valve Implantation Versus Implantation With Balloon Predilatation: Insights From the Brazilian Transcatheter Aortic Valve Replacement Registry. Circ Cardiovasc Interv. 2016;9(8):e003605. doi:10.1161/CIRCINTERVENTIONS.116.003605.

22. Benetos G, Karmpalioti M, Drakopoulou M, et al. One-year clinical and echocardiographic outcomes of direct implantation of a self-expanding valve. Catheter Cardiovasc Interv. 2021;98(3):E403-E411. doi:10.1002/ccd.29389


Supplementary files

  • About one third of heart conduction disorders in trans­catheter aortic valve implantation (TAVI) occur before bioprosthetic valve implantation.
  • The most common heart conduction disorder after TAVI is new-onset complete left bundle branch block, which in most cases is persistent and remains until the patient is discharged from the hospital.
  • Intraoperative Holter monitoring in TAVI can be an important tool for assessing and predicting various heart conduction disorders, as well as determining the optimal postoperative patient management strategy.

Review

For citations:


Baranov A.A., Bystritskaya O.A., Zamaraeva E.S., Badoyan A.G., Khelimsky D.A., Tsydenova A.Yu., Peregudov I.S., Filippenko A.G., Yusupova M.A., Maingart S.V., Fedorchenko A.N., Krestyaninov O.V. Timing and pathogenesis of heart conduction disorders during transcatheter aortic valve implantation: data of intraoperative Holter monitoring. Russian Journal of Cardiology. 2025;30(4):6300. (In Russ.) https://doi.org/10.15829/1560-4071-2025-6300. EDN: WJFZIA

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ISSN 1560-4071 (Print)
ISSN 2618-7620 (Online)