Features of vascular stiffness and central hemodynamics in overweight and obese young women depending on hypertension phenotype

Aim. To evaluate central hemodynamics and vascular stiffness (VS) from the perspective of hypertension (HTN) phenotype in overweight/obese young women.

Material and methods. A total of 104 women with overweight and obesity, aged 18 to 35 years (28,41±0,46), were examined. Based on office and outpatient blood pressure measurements, four following groups were formed: group 1 — persistent normotension (control); group 2 — white coat HTN; group 3 — masked HTN; group 4 — persistent HTN. We studied risk factors, features of central aortic pressure and HF. We used the BPLab diagnostic system (Petr Telegin, Russia). A correlation analysis was performed between HF indicators and some risk factors of the examined subjects.

Results. In the examined women with masked and persistent HTN, the greatest differences from the control group were noted in the 24-hour central hemodynamics parameters — systolic aortic pressure, diastolic aortic pressure, mean aortic pressure and pulse aortic pressure. When assessing aortic stiffness in the specified group of individuals, the maximum RWVao/RWV values reduced to the heart rate of 75 bpm were found in groups with masked and persistent HTN, which significantly exceeds their values in the control group (Р_1-3=0,0002, Р_1-4<0,0001; Р_1-3=0,0111, Р_1-4=0,0125, respectively). Similar changes were noted in the aortic augmentation index. Correlation analysis revealed significant positive relationship between the VS and BMI, as well as waist circumference.

Conclusion. In overweight and obese young women with masked phenotype of HTN, reliably high values of central hemodynamic parameters were found relative to normotensive women. Signs of arterial wall remodeling have been established not only in persistent but also in masked HTN. These data should be taken into account when examining the specified group of individuals and developing measures aimed at identifying masked HTN due to its proven contribution to the development of cardiovascular disease.

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