Electrocardiographic signs of left bundle branch block and prediction of response to biventricular and conduction system pacing
https://doi.org/10.15829/1560-4071-2024-6182
EDN: OBRYEU
Abstract
The paper presents an analysis of Russian and foreign studies on left bundle branch block (LBBB) and the analysis of electrocardiographic (ECG) criteria for selecting patients for cardiac resynchronization therapy. The features of LBBB classification are considered, including true and false forms, as well as differences in conduction block location with a similar ECG performance. Particular attention is paid to the problem of variability of existing ECG criteria and the prognostic significance of individual ECG signs. The importance of developing new criteria for improving diagnostics and increasing the effectiveness of treatment of LBBB patients is emphasized to improve selection for biventricular and conduction system pacing.
Keywords
About the Authors
L. M. MalishevskyRussian Federation
St. Petersburg; Yekaterinburg
Competing Interests:
None
D. S. Lebedev
Russian Federation
St. Petersburg; Yekaterinburg
Competing Interests:
None
References
1. Vassallo JA, Cassidy DM, Marchlinski FE, et al. Endocardial activation of left bundle branch block. Circulation. 1984;69(5):914-23. doi:10.1161/01.cir.69.5.914.
2. Rodriguez LM, Timmermans C, Nabar A, et al. Variable patterns of septal activation in patients with left bundle branch block and heart failure. J Cardiovasc Electrophysiol. 2003;14(2):135-41. doi:10.1046/j.1540-8167.2003.02421.x.
3. Auricchio A, Fantoni C, Regoli F, et al. Characterization of left ventricular activation in patients with heart failure and left bundle-branch block. Circulation. 2004;109(9):1133-9. doi:10.1161/01.CIR.0000118502.91105.F6.
4. Riedlbauchová L, Adla T, Suchánek V, et al. Is left bundle branch block pattern on the ECG caused by variable ventricular activation sequence? Pacing Clin Electrophysiol. 2020;43(5):486-94. doi:10.1111/pace.13914.
5. Strauss DG, Selvester RH, Wagner GS. Defining left bundle branch block in the era of cardiac resynchronization therapy. Am J Cardiol. 2011;107(6):927-34. doi:10.1016/j.amjcard.2010.11.010.
6. Zareba W, Klein H, Cygankiewicz I, et al. Effectiveness of cardiac resynchronization therapy by QRS morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT). Circulation. 2011;123(10):1061-72. doi:10.1161/CIRCULATIONAHA.110.960898.
7. Gold MR, Thebault C, Linde C, et al. Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: results from the Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) study. Circulation. 2012;126:822829. doi:10.1161/CIRCULATIONAHA.112.097709.
8. Birnie DH, Ha A, Higginson L, et al. Impact of QRS morphology and duration on out-comes after cardiac resynchronization therapy: results from the Resynchronization-Defibrillation for Ambulatory Heart Failure Trial (RAFT). Circ Heart Fail. 2013;6(6): 1190-8. doi:10.1161/CIRCHEARTFAILURE.113.000380.
9. Brignole M, Auricchio A, Baron-Esquivias G, et al. 2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). European heart journal. 2013;34(29):2281-329. doi:10.1093/eurheartj/eht150.
10. Mareev VYu, Ageev FT, Arutyunov GP, et al. National guidelines for the diagnosis and treatment of CHF (fourth revision). Approved at the OSS Congress on December 7, 2012, the direction of the OSS on March 31, 2013 and the RKO Congress on September 25, 2013. Journal of Heart failure. 2013;14(7):379-472. (In Russ.) EDN VHDBDT.
11. Sieniewicz BJ, Gould J, Porter B, et al. Understanding non-response to cardiac resynchronisation therapy: common problems and potential solutions. Heart Fail Rev. 2019;24:41-54. doi:10.1007/s10741-018-9734-8.
12. Mascioli G, Padeletti L, Sassone B, et al. Electrocardiographic criteria of true left bundle branch block: a simple sign to predict a better clinical and instrumental response to CRT. Pacing Clin Electrophysiol. 2012;35(8):927-34. doi:10.1111/j.1540-8159.2012.03427.x.
13. Tian Y, Zhang P, Li X, et al. True complete left bundle branch block morphology strongly predicts good response to cardiac resynchronization therapy. Europace. 2013; 15(10):1499-506. doi:10.1093/europace/eut049.
14. Surawicz B, Childers R, Deal BJ, Gettes LS. AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram: part III: intraventricular conduction disturbances: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology. Journal of the American College of Cardiology. 2009;53(11):976-81. doi:10.1016/j.jacc.2008.12.013.
15. Glikson M, Nielsen JC, Kronborg MB, et al.; ESC Scientific Document Group. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy. Eur Heart J. 2021;42(35):3427-520. doi:10.1093/eurheartj/ehab364. Erratum in: Eur Heart J. 2022;43(17):1651. doi:10.1093/eurheartj/ehac075.
16. Chung MK, Patton KK, Lau CP, et al. 2023 HRS/APHRS/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure. Heart Rhythm. 2023;20(9):e17-e91. doi:10.1016/j.hrthm.2023.03.1538.
17. van Deursen CJM, Blaauw Y, Witjens MI, et al. The value of the 12-lead ECG for evaluation and optimization of cardiac resynchronization therapy in daily clinical practice. Journal of Electrocardiology. 2014;47(2):202-11. doi:10.1016/j.jelectrocard.2014.01.007.
18. Jastrzębski M, Kukla P, Kisiel R, et al. Comparison of four LBBB definitions for predicting mortality in patients receiving cardiac resynchronization therapy. Annals of Noninvasive Electrocardiology. 2018;23(5):e12563. doi:10.1111/anec.12563.
19. Caputo ML, van Stipdonk A, Illner A, et al. The definition of left bundle branch block influences the response to cardiac resynchronization therapy. International Journal of Cardiology. 2018;269:165-9. doi:10.1016/j.ijcard.2018.07.060.
20. Tung R, Upadhyay GA. Defining Left Bundle Branch Block Patterns in Cardiac Resynchronisation Therapy: A Return to His Bundle Recordings. Arrhythm Electrophysiol Rev. 2020;9(1):28-33. doi:10.15420/aer.2019.12.
21. van Stipdonk AMW, Hoogland R, ter Horst I, et al. Evaluating Electrocardiography-Based Identification of Cardiac Resynchronization Therapy Responders Beyond Current Left Bundle Branch Block Definitions. JACC: Clinical Electrophysiology. 2020;6(2):193-203. doi:10.1016/j.jacep.2019.10.009.
22. Kuznetsov VA, Malishevsky LM, Todosiychuk VV, Soldatova AM. Evaluation of the relationship of various criteria for the blockade of the left leg of the Gis bundle with the response to cardiac resynchronization therapy in chronic heart failure. Cardiologiia. 2020;60(7):78-85. (In Russ.) doi:10.18087/cardio.2020.7.n785.
23. Upadhyay GA, Vijayaraman P, Nayak HM, et al. On-treatment comparison between corrective His bundle pacing and biventricular pacing for cardiac resynchronization: a secondary analysis of His-SYNC. Heart Rhythm. 2019;16:1797-807. doi:10.1016/j.hrthm.2019.05.009.
24. Vinther M, Risum N, Svendsen JH, et al. A Randomized Trial of His Pacing Versus Biventricular Pacing in Symptomatic HF Patients With Left Bundle Branch Block (His-Alternative). JACC Clin Electrophysiol. 2021;7(11):1422-32. doi:10.1016/j.jacep.2021.04.003.
25. Upadhyay GA, Cherian T, Shatz DY, et al. Intracardiac Delineation of Septal Conduction in Left Bundle-Branch Block Patterns. Circulation. 2019;139(16):1876-88. doi:10.1161/CIRCULATIONAHA.118.038648.
26. Nguyen UC, Verzaal NJ, van Nieuwenhoven FA, et al. Pathobiology of cardiac dyssynchrony and resynchronization therapy. Europace. 2018;20(12):1898-909. doi:10.1093/europace/euy035.
27. Calle S, Coeman M, Demolder A, et al. Aortic valve implantation-induced conduction block as a framework towards a uniform electrocardiographic definition of left bundle branch block. Neth Heart J. 2021;29(12):643-53. doi:10.1007/s12471-021-01565-8.
28. Rimskaya EM, Kashtanova SYu, Salami KhF, et al. Diagnostic criteria for proximal left bundle branch block and their significance in predicting the success of cardiac resynchronization therapy. Russian Journal of Cardiology. 2023;28(8):5403. (In Russ.) doi:10.15829/1560-4071-2023-5403.
29. Malishevsky LM, Zubarev SV, Gurshchenkov AV, et al. Analysis of electrocardiographic signs in hypertrophic cardiomyopathy before and after septal myectomy. New criterion for proximal left bundle branch block. Russian Journal of Cardiology. 2022;27(7):5110. (In Russ.) doi:10.15829/1560-4071-2022-5110.
30. Durrer D, van Dam RT, Freud GE, et al. Total excitation of the isolated human heart. Circulation. 1970;41(6):899-912. doi:10.1161/01.cir.41.6.899.
31. Grant RP, Dodge HT. Mechanisms of QRS complex prolongation in man; left ventricular conduction disturbances. Am J Med. 1956;20(6):834-52. doi:10.1016/0002-9343(56)90204-2.
32. The ESC textbook of cardiovascular medicine. Camm AJ, Lüscher TF, Serruys PW, European Society of Cardiology, editors-Malden, Mass.; Oxford: Blackwell Pub./European Society of Cardiology; 2006. 1122 p. ISBN: 978-1-4051-2695-3.
33. Cosío FG, Palacios J, Pastor A, Núñez A. The Electrocardiogram, in A. John Camm, Thomas F. Lüscher, and Patrick W. Serruys (eds), The ESC Textbook of Cardiovascular Medicine, 2 edn, The European Society of Cardiology (Oxford, 2009; online edn, Oxford Academic, 1 Aug. 2009), doi:10.1093/med/9780199566990.003.002.
34. Aranda JM, Conti JB, Johnson JW, et al. Cardiac resynchronization therapy in patients with heart failure and conduction abnormalities other than left bundle-branch block: analysis of the Multicenter InSync Randomized Clinical Evaluation (MIRACLE). Clinical Cardiology. 2004;27(12):678-82. doi:10.1002/clc.4960271204.
35. Gervais R, Leclercq C, Shankar A, et al. Surface electrocardiogram to predict outcome in candidates for cardiac resynchronization therapy: a sub-analysis of the CARE-HF trial. European Journal of Heart Failure. 2009;11(7):699-705. doi:10.1093/eurjhf/hfp074.
36. Calle S, Timmermans F, De Pooter J. Defining left bundle branch block according to the new 2021 European Society of Cardiology criteria. Neth Heart J. 2022;30(11):495-8. doi:10.1007/s12471-022-01697-5.
37. Beela A, Rijks J, Vernooy K, et al, Associations of 2013 and 2021 ESC definitions of left bundle-branch block with mechanical dyssynchrony and CRT-induced reverse remodeling. European Heart Journal. 2023;44(Supplement_2, November):ehad655.691. doi:10.1093/eurheartj/ehad655.691.
38. Rijks J, Ghossein MA, Wouters PC, et al. Comparison of the relation of the ESC 2021 and ESC 2013 definitions of left bundle branch block with clinical and echocardiographic outcome in cardiac resynchronization therapy. J Cardiovasc Electrophysiol. 2023;34(4): 1006-14. doi:10.1111/jce.15882.
39. Kawashima T, Sato F. Visualizing anatomical evidences on atrioventricular conduction system for TAVI. Int J Cardiol. 2014;174(1):1-6. doi:10.1016/j.ijcard.2014.04.003.
40. Perrin MJ, Green MS, Redpath CJ, et al. Greater response to cardiac resynchronization therapy in patients with true complete left bundle branch block: a PREDICT substudy. Europace. 2012;14(5):690-5. doi:10.1093/europace/eur381.
41. Grebmer C, Friedrich L, Semmler V, et al. Cardiac resynchronisation therapy in patients with left bundle branch block with residual conduction. Indian Pacing Electrophysiol J. 2021;21(1):14-7. doi:10.1016/j.ipej.2020.10.006.
42. Malishevsky LM, Kuznetsov VA, Todosiychuk VV, et al. Diagnostic value of electrocardiographic markers of left bundle branch block in predicting left ventricular reverse remodeling in patients receiving cardiac resynchronization therapy. Russian Journal of Cardiology. 2021;26(9):4500. (In Russ.) doi:10.15829/1560-4071-2021-4500.
Supplementary files
- Diagnosis of left bundle branch block (LBBB) remains a complex clinical problem due to the variety of ventricular activation patterns, as well as different conduction block location with a similar electrocardiographic pattern.
- A comparative analysis of Russian and international criteria for LBBB diagnosis and their prognostic value for cardiac resynchronization therapy (CRT) is presented.
- The advantages and limitations of current electrocardiographic criteria for predicting response to CRT are identified.
- Novel diagnostic approaches and criteria for proximal LBBB, identified based on a study of patients with surgically induced proximal left bundle branch block, are described.
Review
For citations:
Malishevsky L.M., Lebedev D.S. Electrocardiographic signs of left bundle branch block and prediction of response to biventricular and conduction system pacing. Russian Journal of Cardiology. 2024;29(4S):6182. (In Russ.) https://doi.org/10.15829/1560-4071-2024-6182. EDN: OBRYEU