Cardiorenal relationships in individuals with various cardiomyopathies

Aim. To identify cardiorenal relationships and related characteristics in individuals with various cardiomyopathies.

Material and methods. An analysis of 267 patients with cardiomyopathy (CMP) was conducted, of which 204 (76,4%) were men. There were dilated CMP (DCM), hypertrophic CMP (HCM), alcoholic (ACM), ischemic CMP (ICM) and inflammatory CMP (InCM). We assessed the relationships between glomerular filtration rate (GFR) and CMP forms and following echocardiography parameters: ejection fraction (EF), left ventricular (LV) end-systolic (ESD) and end-diastolic dimensions (EDD), left ventricular wall thickness (LVWT), right ventricle (RV), left and right atria.

Results. Among individuals with CMP, a significant decrease in GFR was found in DCM, ICM, and HCM. In men, there was a positive relationship between GFR and EF and a negative relationship between GFR and ESD in DCM (r=0,317, p=0,012 and r=-0,269, p=0,036) and ICM (r=0,359, p=0,017 and r=-0,660, p=0,007). In women, no relationships between GFR and EF were found. In women with DCM, a strong positive relationship between GFR and LVWT (r=0,894, p=0,041) was found. In women with ICM, a negative relationship between GFR and RV (r=-0,650, p=0,003) and ESD (r=-0,829, p=0,042) was found. In women with DCM and ICM, only the RV parameter was included in the regression equations with the dependent variable GFR, while in men, all echocardiography parameters were included. In the general HCM group, there was a negative correlation between GFR and LVWT (r=-0,571, p=0,021). In the HCM group, a negative relationship between GFR and EDD was recorded in young men (r=-0,520, p=0,027) and in young women (r=-0,750, p=0,05).

Conclusion. In individuals with DCM, ICM, and HCM, a decrease in GFR is observed compared to ACM and InCM at the corresponding age. In men with DCM and ICM, a positive correlation of GFR with EF is recorded, and in women with ICM, a negative relationship of GFR with RV. Therefore, sex-specific relationships between GFR and echocardiography parameters in men and women reflect one or another adaptive model of cardiovascular remodeling in CMP. Left ventricular remodeling in CMP with thickening or thinning is associated with a decrease in GFR in both men and women.

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