EFFECT OF SEVOFLURANE EXPOSURE ON ADRIAMYCIN-INDUCED INJURIES TO MYOCYTES
https://doi.org/10.15829/1560-4071-2014-1-ENG-32-34
Abstract
The study is to investigate the potential protective effect of sevoflurane on adriamycin induced myocyte injury. We prepared primary myocyte culture from neonatal rats and subjected the cells to adriamycin treatment. We found that adriamycin treatment induced cell apoptosis, decreased cell vitality, which could be reversed with sevoflurane exposure after the drug treatment, potentially through the regulation of Bcl-2 anti-apoptotic pathway. The study suggested the potential roles of sevoflurane in clinical management of patients after adriamycin chemotherapy.
About the Authors
Li-hua Fan
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China
Xin Han
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China
Qing-quan Lian
Department of Anesthesiology, Wenzhou Medical College, the second Affiliated Hospital, Zhejiang, Wenzhou 325027, China
Jun Li
Department of Anesthesiology, Wenzhou
Medical College, the second Affiliated Hospital, Zhejiang, Wenzhou 325027, China
Hou-xing Lei
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China
NIing Zhang
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China
Xiang-dong Xu
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China
Xiang-hong Lu
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China
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Review
For citations:
Fan L., Han X., Lian Q., Li J., Lei H., Zhang N., Xu X., Lu X. EFFECT OF SEVOFLURANE EXPOSURE ON ADRIAMYCIN-INDUCED INJURIES TO MYOCYTES. Russian Journal of Cardiology. 2014;(1-ENG):32-34. https://doi.org/10.15829/1560-4071-2014-1-ENG-32-34
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