Adipokines and personal anxiety in individuals aged 25-44 years

Aim. To determine the associations of serum adipokines (leptin, adiponectin, leptin/adiponectin index (L/A)) and trait anxiety (TA) in individuals aged 25-44.

Material and methods. This cross-sectional survey of a random representative sample of individuals aged 25-44 in the Oktyabrsky District of Novosibirsk was conducted at the Research Institute of Internal and Preventive Medicine, a branch of the Institute of Cytology and Genetics, during 2013-2016. A total of 933 persons (43,7% men) were examined (response rate 71% of 1314 respondents). General examination and medical history collection were conducted using standard methods included in the WHO MONICA-psychosocial program. TA was assessed using the State-Trait Anxiety Inventory. Biochemical research was performed in the Laboratory of Clinical Biochemical and Hormonal Studies of Internal Diseases.

Results. Among individuals with a high level of anxiety, there are the highest median levels of serum leptin (6573,7 pg/ml) than with a moderate (5017,7 pg/ml) and low

(4171 pg/ml) levels of anxiety. The median L/A index is higher with a high level of TA of 167,7 than with a moderate (74,5) and low (72,2) TA (p=0,002). Median serum adiponectin levels were lower among individuals with high anxiety (33,2 μg/ml) compared to those with moderate (38,9 μg/ml) and low (40,8 μg/ml) anxiety levels. A positive correlation was found between TA and leptin and L/A index, as well as a negative correlation between TA and adiponectin.

Conclusion. Associations were found between high TA and elevated leptin levels, the leptin/adiponectin ratio, and lower adiponectin levels in individuals aged 2544 years.

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