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Infective endocarditis in a patient with hypertrophic obstructive cardiomyopathy: а case report

https://doi.org/10.15829/1560-4071-2025-5859

EDN: KJHLLW

Abstract

Infective endocarditis in patients with hypertrophic cardiomyopathy is a rare clinical combination. However, this combination of diseases increases the already high risk of death in patients with hypertrophic cardiomyopathy. In this regard, early diagnosis of this pathology, timely antibacterial therapy, and, if necessary, surgical treatment are necessary. The article describes a clinical case.

About the Authors

L. L. Sarkisyan
Kuban State Medical University; Research Institute — Ochapovsky Regional Clinical Hospital № 1
Russian Federation

Krasnodar


Competing Interests:

None



S. V. Kruchinova
Kuban State Medical University; Research Institute — Ochapovsky Regional Clinical Hospital № 1
Russian Federation

Krasnodar


Competing Interests:

None



K. V. Skaletsky
Kuban State Medical University; Research Institute — Ochapovsky Regional Clinical Hospital № 1
Russian Federation

Krasnodar


Competing Interests:

None



A. M. Namitokov
Kuban State Medical University; Research Institute — Ochapovsky Regional Clinical Hospital № 1
Russian Federation

Krasnodar


Competing Interests:

None



K. O. Barbukhatti
Kuban State Medical University; Research Institute — Ochapovsky Regional Clinical Hospital № 1
Russian Federation

Krasnodar


Competing Interests:

None



E. D. Kosmacheva
Kuban State Medical University; Research Institute — Ochapovsky Regional Clinical Hospital № 1
Russian Federation

Krasnodar


Competing Interests:

None



References

1. Delgado V, Ajmone Marsan N, de Waha S, et al. 2023 ESC Guidelines for the management of endocarditis [published correction appears in Eur Heart J. 2023 Sep 20;:] [published correction appears in Eur Heart J. 2024 Jan 1;45(1):56]. Eur Heart J. 2023;44(39):3948-4042. doi:10.1093/eurheartj/ehad193.

2. Spirito P, Rapezzi C, Bellone P, Betocchi S, Autore C, Conte MR, Bezante GP, Bruzzi P. Infective endocarditis in hypertrophic cardiomyopathy: prevalence, incidence, and indications for antibiotic prophylaxis. Circulation. 1999 Apr 27;99(16):2132-7. doi: 10.1161/01.cir.99.16.2132. PMID: 10217653.

3. Ostergaard L, Valeur N, Wang A, Bundgaard H, Aslam M, Gislason G, et al. Incidence of infective endocarditis in patients considered at moderate risk. Eur Heart J 2019;40:1355–1361. https://doi.org/10.1093/eurheartj/ehy629.

4. Dominguez F, Ramos A, Bouza E, et al. Infective endocarditis in hypertrophic cardiomyopathy: A multicenter, prospective, cohort study. Medicine (Baltimore). 2016;95(26):e4008. doi:10.1097/MD.0000000000004008.

5. Sims JR, Anavekar NS, Bhatia S, et al. Clinical, Radiographic, and Microbiologic Features of Infective Endocarditis in Patients With Hypertrophic Cardiomyopathy. Am J Cardiol. 2018;121(4):480-484. doi:10.1016/j.amjcard.2017.11.010.

6. Oberoi M, Schaff HV, Nishimura RA, Geske JB, Dearani JA, Ommen SR. Surgical Management of Hypertrophic Cardiomyopathy Complicated by Infective Endocarditis. Ann Thorac Surg. 2022;114(3):744-749. doi:10.1016/j.athoracsur.2022.01.016.

7. N'Guyen Y, Duval X, Revest M, et al. Time interval between infective endocarditis first symptoms and diagnosis: relationship to infective endocarditis characteristics, microorganisms and prognosis. Ann Med. 2017;49(2):117-125. doi:10.1080/07853890.2016.1235282.

8. Maron BJ, Lever H. In defense of antimicrobial prophylaxis for prevention of infective endocarditis in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 2009 Dec 8;54(24):2339-40; author reply 2340. doi: 10.1016/j.jacc.2009.07.050. PMID: 19958977.

9. Carrel T. Commentary: Endocarditis in hypertrophic cardiomyopathy: A reason to strengthen the guidelines? JTCVS Tech. 2020 Nov 17;4:286-287. doi: 10.1016/j.xjtc.2020.10.046. PMID: 34318049; PMCID: PMC8308183.

10. Wu ZW, Yan H. Infective endocarditis in obstructive hypertrophic cardiomyopathy: a case series and literature review. Chin Med J (Engl). 2020;134(9):1125-1126. Published 2020 Dec 14. doi:10.1097/CM9.0000000000001265.

11. Dlewati MM, Harrisingh K, Dabiri R. Infective Endocarditis in Hypertrophic Obstructive Cardiomyopathy After Etonogestrel Implant Removal. Cureus. 2022;14(10):e29810. Published 2022 Oct 1. doi:10.7759/cureus.29810.

12. Morgan-Hughes G, Motwani J. Mitral valve endocarditis in hypertrophic cardiomyopathy: case report and literature review. Heart. 2002;87(6):e8. doi:10.1136/heart.87.6.e8.

13. Lee ME, Kemna M, Schultz AH, McMullan DM. A rare pediatric case of left ventricular outflow tract infective endocarditis in hypertrophic cardiomyopathy. JTCVS Tech. 2020 Sep 22;4:281-282. doi: 10.1016/j.xjtc.2020.09.019. PMID: 34318046; PMCID: PMC8307343.

14. Ishida S, Mutsuga M, Fujita T, Yagami K. Surgical techniques for infectious endocarditis of the mitral valve with hypertrophic cardiomyopathy in Costello syndrome. J Cardiol Cases. 2022 Jan 14;25(6):367-369. doi: 10.1016/j.jccase.2021.12.010. PMID: 35685268; PMCID: PMC9168975


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Indexing metadata ▾
  • The combination of hypertrophic cardiomyopathy and infective endocarditis is quite rare.
  • The main diagnostic method for this condition is echocardiography.
  • Treatment of this group of patients requires an individual approach. Depending on the location and area of involvement, the scope of treatment may include antibiotic therapy, lavage of heart cavities, replacement of affected valves, as well as treatment of hypertrophy by septal myectomy.
  • This case demonstrates the difficulties in timely diagnosis of endocarditis in a patient with hypertrophic cardiomyopathy and is aimed at developing greater clinical alertness among colleagues.

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For citations:


Sarkisyan L.L., Kruchinova S.V., Skaletsky K.V., Namitokov A.M., Barbukhatti K.O., Kosmacheva E.D. Infective endocarditis in a patient with hypertrophic obstructive cardiomyopathy: а case report. Russian Journal of Cardiology. 2025;30(5S):5859. (In Russ.) https://doi.org/10.15829/1560-4071-2025-5859. EDN: KJHLLW

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ISSN 1560-4071 (Print)
ISSN 2618-7620 (Online)