Relationships and Activities. The study is supported by OOO AstraZeneca Phar­maceuticals.

Heart failure (HF) is a global health problem. Despite advances in the development of effective treatments for patients with heart failure, morbidity and mortality from remain high, and the prognosis is poor. However, there is potential to improve outcomes in HF patients with current disease-modifying therapy. Planning needs and resources, assessing the effectiveness of care for HF patients in clinical practice requires high-quality epidemiological data. Previously performed Russian observational studies of HF were characterized by relatively small sample sizes, inclusion of patients in only one or a few regions, strict selection criteria, single-stage design, or short follow-up. The rationale and design of the all-Russian prospective observational multicenter registry study "PRIORITET-CHF", which included 20000 patients with HF throughout the Russian Federation, is presented. The main aims of the study are to (1) describe baseline clinical and demographic characteristics in outpatients with HF in the Russian Federation and (2) characterize routine therapy and evaluate the compliance of treatment for HF with reduced ejection fraction with current clinical guidelines.

1. GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1211-59. doi:10.1016/S0140-6736(17)32154-2.

2. Lloyd-Jones DM, Larson MG, Leip EP, et al. Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation. 2002;106:3068-72. doi:10.1161/01.cir.0000039105.49749.6f.

3. Jones NR, Roalfe AK, Adoki I, et al. Survival of patients with chronic heart failure in the community: a systematic review and meta-analysis. Eur J Heart Fail. 2019;21(11):1306-25. doi:10.1002/ejhf.1594.

4. Mamas MA, Sperrin M, Watson MC, et al. Do patients have worse outcomes in heart failure than in cancer? A primary care-based cohort study with 10-year follow-up in Scotland. Eur J Heart Fail. 2017;19:1095-104. doi:10.1002/ejhf.822.

5. Fomin IV. Chronic heart failure in Russian Federation: what do we know and what to do. Russian Journal of Cardiology. 2016;(8):7-13. (In Russ.) doi:10.15829/1560-4071-2016-8-7-13.

6. Polyakov DS, Fomin IV, Belenkov YuN, et al. Chronic heart failure in the Russian Federation: what has changed over 20 years of follow-up? Results of the EPOCH-CHF study. Kardiologiia. 2021;61(4):4-14. (In Russ.) doi:10.18087/cardio.2021.4.n1628.

7. Stolfo D, Lund LH, Benson L, et al. Persistent High Burden of Heart Failure Across the Ejection Fraction Spectrum in a Nationwide Setting. J Am Heart Assoc. 2022;11(22):e026708. doi:10.1161/JAHA.122.026708.

8. Madelaire C, Gustafsson F, Kristensen SL, et al. Burden and Causes of Hospital Admissions in Heart Failure During the Last Year of Life. JACC Heart Fail. 2019;7(7):561-70. doi:10.1016/j.jchf.2019.03.018.

9. Eguchi S, Morita Y, Mitani H, et al. Burden of repeated hospitalizations on patients with heart failure: an analysis of administrative and claims data in Japan. Drugs — Real World Outcomes. 2022;9:377-89. doi:10.1007/s40801-022-00315-5.

10. Arutyunov AG, Dragunov DO, Arutyunov GP, et al. First Open Study of Syndrome of Acute Decompensation of Heart Failure and Concomitant Diseases in Russian Federation: Independent Registry ORAKUL. Kardiologiia. 2015;55(5):12-21. (In Russ.)

11. Hollenberg SM, Stevenson LW, Ahmad T, et al. 2019 ACC expert consensus decision pathway on risk assessment, management, and clinical trajectory of patients hospitalized with heart failure: a report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2019;74(15):1966-2011. doi:10.1016/j.jacc.2019.08.001.

12. Ferreira JP, Kraus S, Mitchell S, et al. World Heart Federation Roadmap for Heart Failure. Glob Heart. 2019;14(3):197-214. doi:10.1016/j.gheart.2019.07.004.

13. Vaduganathan M, Claggett BL, Jhund PS, et al. Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with heart failure with reduced ejection fraction: a comparative analysis of three randomised controlled trials. Lancet. 2020;396(10244):121-8. doi:10.1016/S0140-6736(20)30748-0.

14. Tromp J, Ouwerkerk W, van Veldhuisen DJ, et al. A Systematic Review and Network Meta-Analysis of Pharmacological Treatment of Heart Failure With Reduced Ejection Fraction [published correction appears in JACC Heart Fail. 2022;10(4):295-6]. JACC Heart Fail. 2022;10(2):73-84. doi:10.1016/j.jchf.2021.09.004.

15. Shlyakhto EV, Zvartau NE, Villevalde SV, et al. Implemented models and elements for heart failure care in the regions of the Russian Federation: prospects for transformation into regional cardiovascular risk management systems. Russian Journal of Cardiology. 2020;25(4):3792. (In Russ.). doi:10.15829/1560-4071-2020-4-3792.

16. Villevalde SV, Soloveva AE, Zvartau NE, et al. Principles of organization of medical care for patients with heart failure in the system of cardiovascular risk management: focus on continuity of care and patient routing. Practical materials. Russian Journal of Cardiology. 2021;26(3S):4558. (In Russ.) doi:10.15829/1560-4071-2021-4558.

17. Arutunov AG, Rilova AK, Arutunov GP. Modern clinical characteristics of patients with circulatory decompensation. The clinical phenotypes of patients. Heart failure. 2014;15(1):23-32. (In Russ.)

18. Oshchepkova EV, Lazareva NV, Satlykova DF, et al. The First Results of the Russian Register of Chronic Heart Failure. Kardiologiia. 2015;55(5):22-8. (In Russ.)

19. Sitnikova MYu, Lyasnikova EA, Yurchenko AV, et al. Results of 3 years work of the Russian hospital register of chronic heart failure. Kardiologiia. 2015;55(10):5-13. (In Russ.)

20. Zhirov IV, Romanova NV, Tereshchenko SN, et al. Epidemiology and Management of Heart Failure Patients With Atrial Fibrillation. Kardiologiia. 2015;55(3):91-6. (In Russ.)

21. Russian Society of Cardiology (RSC). 2020 Clinical practice guidelines for Chronic heart failure. Russian Journal of Cardiology. 2020;25(11):4083. (In Russ.) doi:10.15829/1560-4071-2020-4083.