Debating points of anticoagulation in the prevention of venous thromboembolism in pregnant women with cardiovascular and systemic diseases. Expert council resolution
https://doi.org/10.15829/1560-4071-2023-5421
Abstract
On December 18, 2022, an interdisciplinary Expert Council was held in St. Petersburg, dedicated to the debatable issues of anticoagulation in the prevention of venous thromboembolism in pregnant women with cardiovascular and systemic diseases, at which a number of proposals and guidelines were adopted, and the results of the Highlow study were considered. Leading experts from the Russian Society of Cardiology, the Russian Society of Obstetricians and Gynecologists, the National Association of Specialists in Thrombosis, Clinical Hemostaseology and Hemorheology took part in the Expert Council.
About the Authors
O. B. IrtyugaRussian Federation
St. Petersburg
R. G. Shmakov
Russian Federation
Moscow
Y. V. Vavilova
Russian Federation
St. Petersburg
I. E. Zazerskaya
Russian Federation
St. Petersburg
Z. S. Khodzhaeva
Russian Federation
Moscow
V. K. Lebedeva
Russian Federation
St. Petersburg
R. I. Stryuk
Russian Federation
Moscow
References
1. Struyk RI, Bunin YA, et al. Diagnosis and treatment cardiovascular diseases during pregnancy 2018. National Guidelines. Russian Journal of Cardiology. 2018;(3):91-134. (In Russ.) doi:10.15829/1560-4071-2018-3-91-134.
2. Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, et al. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy: The Task Force for the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). European Heart Journal. 2018;39(34):3165-241. doi:10.1093/eurheartj/ehy340.
3. Bleker SM, Buchmüller A, Chauleur C, et al. Low-molecular-weight heparin to prevent recurrent venous thromboembolism in pregnancy: Rationale and design of the Highlow study, a randomised trial of two doses. Thrombosis Research. 2016;144:62-8. doi:10.1016/j.thromres.2016.06.001.
4. Bistervels IM, Buchmüller A, Wiegers HMG, et al. Intermediate dose versus low-dose lowmolecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial. Lancet. 2022;400(10365):1777-87. doi:10.1016/S0140-6736(22)02128-6.
5. American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins — Obstetrics. ACOG Practice Bulletin No 196: Thromboembolism in Pregnancy. Obstet Gynecol. 2018;132(1):e1-e17. doi:10.1097/AOG.0000000000002706.
6. Zabolotskich IB, Bautin AE, Bayalieva AZh. Russian National Methodological Guidelines "Perioperative management patients with heart valve comorbidities". Russian Journal of Anаеsthesiology and Reanimatology. 2020;4:6-31. (In Russ.) doi:10.17116/anaesthesiology20200416.
7. Heidenreich PA, Bozkurt B, Aquilar D, et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/ American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;3;145(18):e895-e1032. doi:10.1161/CIR.0000000000001063.
8. Roos-Hesselink J, Baris L, Johnson M, et al. Pregnancy outcomes in women with cardiovascular disease: evolving trends over 10 years in the ESC Registry Of Pregnancy And Cardiac disease (ROPAC). European Heart Journal. 2019;40(47):3848-55. doi:10.1093/eurheartj/ehz136.
9. Williams DS, Mikhova K, Sodhi S, et al. Arrhythmias and Pregnancy Management of Preexisting and New-Onset Maternal Arrhythmias. Cardiol Clin. 2021;39:67-75. doi:10.1016/j.ccl.2020.09.013.
10. Arakelyan MG, Bockeria LA, Vasilieva EYu, et al. Clinical guidelines for Atrial fibrillation and atrial flutter. Russian Journal of Cardiology. 2021;26(7):4594. (In Russ.) doi:10.15829/1560-4071-2021-4594.
11. Hindricks G, Potpara T, Dagres N, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. European Heart Journal. 2021;42(5):373-498. doi:10.1093/eurheartj/ehaa612.
12. Sisto M, Ribatti D, Lisi S, et al. Organ Fibrosis and Autoimmunity: The Role of Inflammation in TGFβ-Dependent EMT. Biomolecules. 2021;11,310:2-26. doi:10.3390/biom11020310.
13. Sukontseva TA, Kaplina OYu. On the pathogenesis of thrombosis in antiphospholipid syndrome. J Obstetrics, gynecology, and reproduction. 2018;12(3):72-8. doi:10.17749/23137347.2018.12.3.072-078.
14. Bates ShM, Greer IA, Middeldorp S, et al. VTE, Thrombophilia, Antithrombotic Therapy, and Pregnancy Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. CHEST. 2012;141(Suppl 2):E691S-E736S. doi:10.1378/chest.11-2300.
15. Tam WH, Ma RC, Yang X, et al. Glucose intolerance and cardiometabolic risk in adolescents exposed to maternal gestational diabetes: a 15-year follow-up study. Diabetes Care. 2010;33(6):1382-4. doi:10.2337/dc09-2343.
16. Hakanen T, Saha MT, Salo MK, et al. Mothers with gestational diabetes are more likely to give birth to children who experience early weight problems. Acta Paediatr. 2016;105(10):1166-72. doi:10.1111/apa.13468.
17. Domingueti CP, Dusse LM, Carvalho Md, et al. Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. J Diabetes Complications. 2016;30(4):738-45. doi:10.1016/j.jdiacomp.2015.12.018.
18. Shmakov RG, Vavilova TV, Nikolaeva MG, et al. Brief algorithms for the diagnosis, prevention and treatment of venous thromboembolic complications during pregnancy. Obstetrics and Gynecology. 2022;12 (appendix):4-12. (In Russ.)
19. Babin JL, Traylor KL, Witt DM. Laboratory Monitoring of Low-Molecular-Weight Heparins and Fondaparinux. Semin Thromb Hemost. 2017;43(3):261-9. doi:10.1055/s-00361581129.
Review
For citations:
Irtyuga O.B., Shmakov R.G., Vavilova Y.V., Zazerskaya I.E., Khodzhaeva Z.S., Lebedeva V.K., Stryuk R.I. Debating points of anticoagulation in the prevention of venous thromboembolism in pregnant women with cardiovascular and systemic diseases. Expert council resolution. Russian Journal of Cardiology. 2023;28(4):5421. (In Russ.) https://doi.org/10.15829/1560-4071-2023-5421







































