COMPARATIVE ANALYSIS OF DIAGNOSTIC METHODS FOR SUBCLINICAL VESSELS LESION (UNDER THE COHORT OF EPIDEMIOLOGICAL STUDY ESSE-RF)

Aim. To assess correlations of vessel wall stiffness with traditional risk factors according to various diagnostics methods, and the relation of those to each other in population of Saint-Petersburg citizens with different level of cardiovascular risk.

Material and methods. Under the epidemiological study ESSE-RF framework, 452 citizens of Saint-Petersburg were investigated (men — 203, women — 249). Anthropometry, blood pressure measurement, blood chemistry were done according to standard protocols. In instrumental assessment we simultaneously studied carotidfemoral pulse wave velocity (cfPWV) with SphygmoCor device, and ankle-brachial index (CAVI) via Vasera device. Cardiovascular risk was estimated with SCORE.

Results. 341 (75,4%) of participants did not have any marker of arteries lesion. Non-significantly more common was the deviation from reference ranges of CAVI (33 (7,3%)) comparing to cfPWV (21 (4,6%)). Also the significant relations were found for cfPWV (β=0,04, p<0,001), and for CAVI (β=0,02, p=0,01) regardless the gender; cfPWV values were significantly related to SBP (β=0,03, p<0,0001 for both genders) and with glucose levels (β=0,24 for men (p=0,03) and β=0,40 for women (p=0,004)). In patients with arterial hypertension there is higher probability of higher vascular wall stiffness by cfPWV (OR=11,2 95%; CI=3,6-34,9, р<0,0001) if to compare with CAVI (OR=3,3; 95% CI=1,2-10,6, р=0,03).

Conclusion. In populational selection of Saint-Petersburg citizens there is low prevalence of subclinical arteries lesion. Applanation tonometry data shows that the severity of vascular stiffness is directly proportional to the increase of total cardiovascular risk. Mean values of cfPWV are significantly higher in men, probably due to higher part of arterial hypertension and metabolic disorders. Increase of the age is associated with increased stiffness regardless of the method of investigation. Applanation tonometry makes it to reveal the increase of stiffness at earlier stage of arterial hypertension comparing to volumetric sphygmography. Values of vascular stiffness, obtained via different methods, correlate weakly with each other, so these methods cannot be treated as equal.

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