RELATION OF OXIDATIVE PARAMETERS OF LOW DENSITY LIPOPROTEIDES WITH THE AGE IN MALE POPULATION OF NOVOSIBIRSK CITY

Aim. Assessment of the relation of oxidative LDL changes with the age (getting older), incuding the dependence from a row of the main cardiovascular risk factors in male population ofNovosibirskcity.

Material and methods. Totally, 1024 males included, of 47-73 y.o. (mean age — 61,1±0,3 y.o.) of the population cohort ofNovosibirsk. Biochemical methods were used to define baseline levels of lipid peroxidation products (LPP) in low density lipoproteides (LDL) and resistance of LDL to oxidation in vitro.

Results. The significant decrease of LPP was found in the separated LDL and the increase of LDL resistance to oxidation in vitro with increasing age in male population. There were no significant influences of smoking or increased BP on the association of oxidated LDL with the age. With significant relation of the total cholesterol, HDL-cholesterol and higher body weight on oxidation changes of LDL, nevertheless, in older cohort there were less prominent potentially atherogenic oxidative changes of LDL (lower baseline level of LPP in LDL and higher resistance of LDL to oxidation in vitro) comparing with younger men.

Conclusion. The results obtained, point on the significant influence of the age on the mentioned parameters and represent a tendency towards age-related decrease of atherogenic LDL oxidation processes activity.

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