EVALUATION OF CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH RHEUMATOID ARTHRITIS
https://doi.org/10.15829/1560-4071-2016-2-71-74
Abstract
Aim. To find out the relation between the pro-inflammatory cytokines level in serum, and cardiovascular markers in rheumatoid arthritis (RA) patients, as the comorbidities are prevalent in this group of patients.
Material and methods. Totally, 620 RA patients studied with RA (diagnosis according to ACR/EULAR 2010 criteria), hospitalized to rheumatologic department at the age 43,4±10 y.; 95,4% of patients were positive for CCPA, activity by DAS 28 was II, III; of those 85,4% women with disease duration 3-15 y. Level of cytokines (IL-1 и TNF-α) was measured by ЕLISA assay and TNF-α assay (“Picon”, Russia). Also, VLDL, TG and hsCRP were measured in the serum.
Results. Data analysis showed statistically significant increase of IL-1 and TNF-α in RA patients serum (p<0,001). As a result of correlation analysis the moderate and strong significant relation was found between the values of systolic blood pressure and cytokines level — 0,742 (p<0,02) and 0,521 (p<0,05), VLDL 0,621 (p<0,01) and 0,578 (p<0,05), TG 0,512 (p<0,01) and 0,364 (p<0,05), hsCRP 0,821 (p<0,05) and 0,632 (p<0,05) respectively for IL-1 and TNF-α.
Conclusion. The level of pro-inflammatory cytokines (IL-1, TNF-α) might be a nondirect risk factor of development and progression of arterial hypertension and atherosclerosis in RA patients, that is necessary to take into account in such patients management.
About the Authors
I. A. StarodubtsevaRussian Federation
Voronezh
Competing Interests:
Конфликт интересов не заявляется
L. V. Vasilieva
Russian Federation
Voronezh
References
1. Michaud K. Comorbidities in rheumatoid arthritis. Best Practice & Research Clinical Rheumatology 2007; 21 (5): 885-906.
2. Mazurov VI, Stolov CB, Zarajskij MI. The immunological mechanisms in the pathogenesis of coronary atherosclerosis Terapevticheskij arhiv. 2005; 77 (9): 24-8. Russian. (Мазуров В.И., Столов C.B., Зарайский М.И. Иммунологические механизмы в патогенезе коронарного атеросклероза. Терапевтический архив 2005; 77 (9): 24-8.
3. Firestein G, Panayiand G, Wollheim F. Rheumatoid arthritis. Oxford: Oxford University Press, 2006: 173-92.
4. Avina-Zubieta JA, Choi HK, Sadatsafavi M, et al. Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies. Arthritis Rheum 2008; 59:1690-7.
5. López-Mejías R, García-Bermúdez M, González-Juanatey C, et al. NFKB-1 -94 ATTG ins/del polymorphism (rs28362491) is associated with cardiovascular disease in patients with rheumatoid arthritis. Atherosclerosis 2012; 224: 426-9.
6. Dessein PH, Joffe BI, Veller MG, et al. Traditional and nontraditional cardiovascular risk factors are associated with atherosclerosis in rheumatoid arthritis. J. Rheumatol 2005; 32: 435-42.
7. González-Gay MA, González-Juanatey C. Inflammation and lipid profile in rheumatoid arthritis: bridging an apparent paradox. Annals of the Rheumatic Diseases 2014; 73 (7): 1281-3.
8. González-Gay MA, González-Juanatey C, Martin J. High –grade C-reactive protein elevation correlates with accelerated atherogenesis in patients with rheumatoid arthritis. J. Rheumatol 2005; 32: 1219-23.
9. González-Gay MA, González-Juanatey C, Lopez-Diaz MJ, et al. HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis. Arthritis Rheum 2007; 57: 125-32.
10. Naumov AV. The efficacy and safety of diacerein in the therapy of chronic pain in osteoarthritis in patients with cardiovascular comorbidity in contraindications to NsAIDs. Poliklinika 2015; 4: 1-6. Russian (Наумов А.В. Эффективность и безопасность диацереина в терапии хронической боли при остеоартрите у пациентов с сердечно-сосудистой коморбидностью и противопоказаниями к НПВП. Поликлиника 2015; 4: 1-6.)
11. Nasonov EL, Mazurov VI, Karateev DE, et al. Project: recommendations on treatment of rheumatoid arthritis developed by all - Russian public organization «Association of rheumatologists of Russia»-2014 (part 1). Nauchno-prakticheskaja revmatologija 2015; 5s (53): 1-17. In Russian (Насонов Е.Л., Мазуров В.И., Каратеев Д.Е., и др. Проект рекомендаций по лечению ревматоидного артрита Общероссийской общественной организации «Ассоциация ревматологов России» -2014 (часть 1). Научно-практическая ревматология 2015;5 s (53): 1-17).
12. Arnett FC, Edworthy SM, Bloch DA, et al. American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis and Rheumatism 1988; 31: 315-24.
13. Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/ European League against Rheumatism collaborative initiative 2010; 69: 1580-8.
14. Национальный стандарт Российской Федерации «Лаборатории медицинские. Частные требования к качеству и компетентности» (http://docs.cntd.ru/document/gost-r-iso-15189-2009, дата обращения 7.12.2015).
15. Roubille C, Richer V, Starnino T et al. The effects of TNF inhibitors, methotrexate, NSAIDs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis. Annals of the Rheumatic Diseases 2014; 73 (2): 126.
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Starodubtseva I.A., Vasilieva L.V. EVALUATION OF CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH RHEUMATOID ARTHRITIS. Russian Journal of Cardiology. 2016;(2):71-74. (In Russ.) https://doi.org/10.15829/1560-4071-2016-2-71-74