Перспективы применения комбинации периндоприла и амлодипина у пациентов с артериальной гипертензией и/или ишемической болезнью сердца и COVID-19: фокус на эндотелий

Вспышка пандемии новой коронавирусной инфекции (COVID-19) представляет собой продолжающуюся чрезвычайную ситуацию в области здравоохранения, вызвавшую беспрецедентную заболеваемость и смертность. COVID-19 — это заболевание, вызываемое SARS-CoV-2, вирусом, поражающим не только легкие, но и сердечно-сосудистую систему. Серьезным теоретическим обоснованием мультисистемного эффекта COVID-19 считается наличие тесной взаимосвязи между ним и эндотелиальной дисфункцией, которая, согласно консенсусу экспертов, признана решающей для патогенеза и тяжести заболевания. Учитывая, что эндотелиальная дисфункция рассматривается в качестве основного патофизиологического процесса при тяжелом и/или длительном течении COVID-19 и, вероятно, является общим знаменателем множества клинических аспектов тяжёлого течения заболевания, в настоящем обзоре представлены научные данные о влиянии периндоприла и амлодипина у пациентов с артериальной гипертензией и/или ишемической болезнью сердца и COVID-19 на функцию эндотелия.

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