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International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV SARS-CoV-2): analysis of 1,000 patients

  G. P. Arutyunov,   E. I. Tarlovskaya,   A. G. Arutyunov,   Y. N. Belenkov,   A. O. Konradi,   Y. M. Lopatin,   S. N. Tereshchenko,   A. P. Rebrov,   A. I. Chesnikova,   I. V. Fomin,   N. V. Grigorieva,   M. V. Boldina,   A. R. Vaisberg,   A. S. Blagonravova,   E. V. Makarova,   I. I. Shaposhnik,   T. Yu. Kuznetsova,   S. V. Malchikova,   D. N. Protsenko, A. V. Evzerikhina,   M. M. Petrova,   I. V. Demko, D. V. Saphonov,   H. G. Hayrapetyan,   A. S. Galyavich,   Z. F. Kim,   A. B. Sugraliev,   S. V. Nedogoda,   V. V. Tsoma,   S. A. Sayganov,   V. V. Gomonova,   I. V. Gubareva,   A. Sh. Sarybaev, E. V. Koroleva,   O. E. Vilkova, I. Y. Fomina, I. A. Pudova,   D. V. Soloveva,   N. V. Kiseleva, N. V. Zelyaeva, I. M. Kouranova, V. A. Pogrebetskaya,   F. N. Muradova,   O. Y. Badina,   O. V. Kovalishena,   E. A. Galova,   S. S. Plastinina,   N. A. Lyubavina,   N. N. Vezikova,   V. I. Levankova,   S. Yu. Ivanova,   A. N. Ermilova, R. G. Muradyan,   R. V. Gostishev,   E. P. Tikhonova,   T. Y. Kuzmina,   I. A. Soloveva,   A. Yu. Kraposhina,   M. I. Kolyadich, T. P. Kolchinskaya,   V. V. Genkel,   A. S. Kuznetsova,   M. V. Kazakovtseva,   A. A. Odegova,   T. I. Chudinovskikh,   S. V. Baramzina, N. A. Rozanova, A. Sh. Kerimova, N. A. Krivosheina, S. Y. Chukhlova, A. A. Levchenko,   H. G. Avoyan, K. K. Azarian, Sh. N. Musaelian, S. A. Avetisian,   M. E. Levin,   O. V. Karpov,   F. M. Sokhova,   L. A. Burygina, T. V. Sheshina, A. A. Tiurin, O. Yu. Dolgikh, E. V. Kazymova,   D. Yu. Konstantinov, O. A. Chumakova,   O. V. Kondriakova,   K. Yu. Shishkov, T. S. Fil,   N. A. Prokofeva,   M. P. Konoval,   A. A. Simonov,   A. M. Bitieva, N. A. Trostianetckaia, M. B. Cholponbaeva, Zh. B. Kerimbekova, M. Y. Duyshobayev, A. Ch. Akunov,   N. A. Kushubakova,   E. S. Melnikov, E. S. Kim, S. Y. Sherbakov,   D. A. Trofimov,   D. S. Evdokimov, D. A. Ayipova,   I. A. Duvanov, A. K. Abdrahmanova, G. T. Aimakhanova, Sh. O. Ospanova, G. M. Dabylova, A. T. Tursunova,   D. S. Xaskaeva,   A. A. Tulichev,   E. Yu. Ashina, V. A. Kordukova,   O. Yu. Barisheva,   K. E. Egorova,   D. D. Varlamova,   T. V. Kuprina,   E. V. Pahomova,   N. Yu. Kurchugina, I. A. Frolova, K. V. Mazalov, A. K. Subbotin, N. A. Kamardina, N. V. Zarechnova, E. M. Mamutova,   L. A. Smirnova,   A. V. Klimova,   L. D. Shakhgildyan, D. S. Tokmin, D. I. Tupitsin, T. V. Kriukova, N. A. Rakov,   D. S. Polyakov

https://doi.org/10.15829/29/1560-4071-2020-4165

Abstract

COVID-19 is a severe infection with high mortality. The concept of the disease has been shaped to a greater extent on the basis of large registers from the USA, Spain, Italy, and China. However, there is no information on the disease characteristics in Caucasian patients.
Therefore, we created an international register with the estimated capacity of 5,000 patients — Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (AKTIV SARS-CoV-2), which brought together professionals from the Russian Federation, Republic of Armenia, Republic of Kazakhstan, and Kyrgyz Republic. The article presents the first analysis of the register involving 1,003 patients. It was shown that the most significant difference of the Caucasian population was the higher effect of multimorbidity on the mortality risk vs other registers. More pronounced effect on mortality of such diseases as diabetes, obesity, hypertension, chronic kidney disease, and age over 60 years was also revealed.

About the Authors

G. P. Arutyunov
РНИМУ им. Н.И. Пирогова
Russian Federation

Competing Interests:

No.



E. I. Tarlovskaya
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


A. G. Arutyunov
РНИМУ им. Н.И. Пирогова
Russian Federation

Competing Interests: No.


Y. N. Belenkov
Первый МГМУ им И.М. Сеченова
Russian Federation

Competing Interests: No.


A. O. Konradi
НМИЦ им. В.А. Алмазова МЗ РФ
Russian Federation

Competing Interests: No.


Y. M. Lopatin
ВолгГМУ МЗ РФ
Russian Federation

Competing Interests: No.


S. N. Tereshchenko
НМИЦ кардиологии Минздрава России
Russian Federation

Competing Interests: No.


A. P. Rebrov
СГМУ им. В.И. Разумовского
Russian Federation

Competing Interests: No.


A. I. Chesnikova
РостГМУ
Russian Federation

Competing Interests: No.


I. V. Fomin
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


N. V. Grigorieva
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


M. V. Boldina
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


A. R. Vaisberg
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


A. S. Blagonravova
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


E. V. Makarova
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


I. I. Shaposhnik
ЮУГМУ МЗ РФ
Russian Federation

Competing Interests: No.


T. Yu. Kuznetsova
Медицинский институт ПетрГУ
Russian Federation

Competing Interests: No.


S. V. Malchikova
КГМУ
Russian Federation

Competing Interests: No.


D. N. Protsenko
Городская клиническая больница № 40
Russian Federation

Competing Interests: No.


A. V. Evzerikhina
ГБУЗ МО КГБ № 1
Russian Federation

Competing Interests: No.


M. M. Petrova
КГМУ им. проф. В.Ф. Войно-Ясенецкого
Russian Federation

Competing Interests: No.


I. V. Demko
КГБУЗ Краевая клиническая больница; ФГБОУ ВО КрасГМУ им. проф. В.Ф. Войно-Ясенецкого МЗ РФ
Russian Federation

Competing Interests: No.


D. V. Saphonov
МБУЗ ГБСМП
Russian Federation

Competing Interests: No.


H. G. Hayrapetyan
Медицинский центр Эребуни, Клиника кардиологии кардиохирургии
Armenia

Competing Interests: No.


A. S. Galyavich
Казанский государственный медицинский университет
Russian Federation

Competing Interests: No.


Z. F. Kim
ГАУЗ ГКБ № 7
Russian Federation

Competing Interests: No.


A. B. Sugraliev
КазНМУ им. С.Д. Асфендиярова
Kazakhstan

Competing Interests: No.


S. V. Nedogoda
ВолгГМУ МЗ РФ
Russian Federation

Competing Interests: No.


V. V. Tsoma
Институт НМФО ВолгГМУ МЗ РФ; КЗ Волгоградской области
Russian Federation

Competing Interests: No.


S. A. Sayganov
СЗГМУ им. И.И. Мечникова МЗ РФ
Russian Federation

Competing Interests: No.


V. V. Gomonova
СЗГМУ им. И.И. Мечникова МЗ РФ
Russian Federation

Competing Interests: No.


I. V. Gubareva
СамГМУ МЗ РФ
Russian Federation

Competing Interests: No.


A. Sh. Sarybaev
Национальный центра кардиологии и терапии им. М.М. Миррахимова
Kyrgyzstan

Competing Interests: No.


E. V. Koroleva
ГБУЗ НО Городская клиническая больница № 5 Нижегородского района
Russian Federation

Competing Interests: No.


O. E. Vilkova
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


I. Y. Fomina
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


I. A. Pudova
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


D. V. Soloveva
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


N. V. Kiseleva
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


N. V. Zelyaeva
Городская больница № 28 Московского района города Нижнего Новгорода
Russian Federation

Competing Interests: No.


I. M. Kouranova
Городецкая ЦРБ
Russian Federation

Competing Interests: No.


V. A. Pogrebetskaya
Городская клиническая больница № 38 Нижегородского района города Нижнего Новгорода
Russian Federation

Competing Interests: No.


F. N. Muradova
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


O. Y. Badina
Приволжский окружной медицинский центр ФМБА России
Russian Federation

Competing Interests: No.


O. V. Kovalishena
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


E. A. Galova
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


S. S. Plastinina
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


N. A. Lyubavina
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


N. N. Vezikova
ПетрГУ
Russian Federation

Competing Interests: No.


V. I. Levankova
ГБУЗ Городская поликлиника № 1
Russian Federation

Competing Interests: No.


S. Yu. Ivanova
ГБУЗ МЗ Республики Карелия, Госпиталь для ветеранов войн
Russian Federation

Competing Interests: No.


A. N. Ermilova
РНИМУ им. Н.И. Пирогова
Russian Federation

Competing Interests: No.


R. G. Muradyan
ГКБ № 4 ДЗМ; РНИМУ им. Н.И. Пирогова
Russian Federation

Competing Interests: No.


R. V. Gostishev
Городская клиническая больница № 40
Russian Federation

Competing Interests: No.


E. P. Tikhonova
КГМУ им. проф. В.Ф. Войно-Ясенецкого
Russian Federation

Competing Interests: No.


T. Y. Kuzmina
КГМУ им. проф. В.Ф. Войно-Ясенецкого
Russian Federation

Competing Interests: No.


I. A. Soloveva
КрасГМУ им. проф. В.Ф. Войно-Ясенецкого МЗ РФ
Russian Federation

Competing Interests: No.


A. Yu. Kraposhina
КрасГМУ им. проф. В.Ф. Войно-Ясенецкого Минздрава России
Russian Federation

Competing Interests: No.


M. I. Kolyadich
ЮУГМУ МЗ РФ; МАУЗ ОТКЗ ГКБ 1
Russian Federation

Competing Interests: No.


T. P. Kolchinskaya
МАУЗ ОТКЗ ГКБ 1
Russian Federation

Competing Interests: No.


V. V. Genkel
ЮУГМУ МЗ РФ
Russian Federation

Competing Interests: No.


A. S. Kuznetsova
ЮУГМУ МЗ РФ
Russian Federation

Competing Interests: No.


M. V. Kazakovtseva
КГМУ
Russian Federation

Competing Interests: No.


A. A. Odegova
КГМУ
Russian Federation

Competing Interests: No.


T. I. Chudinovskikh
КГМУ
Russian Federation

Competing Interests: No.


S. V. Baramzina
КГМУ
Russian Federation

Competing Interests: No.


N. A. Rozanova
ГБУЗ МО КГБ № 1
Russian Federation

Competing Interests: No.


A. Sh. Kerimova
Городская клиническая больница № 40
Russian Federation

Competing Interests: No.


N. A. Krivosheina
МБУЗ ГБСМП
Russian Federation

Competing Interests: No.


S. Y. Chukhlova
МБУЗ ГБСМП
Russian Federation

Competing Interests: No.


A. A. Levchenko
МБУЗ ГБСМП
Russian Federation

Competing Interests: No.


H. G. Avoyan
Медицинский центр Эребуни, Клиника кардиологии кардиохирургии
Armenia

Competing Interests: No.


K. K. Azarian
Медицинский центр Эребуни, Клиника кардиологии кардиохирургии
Armenia

Competing Interests: No.


Sh. N. Musaelian
ЕГМУ; Медицинский центр Эребуни, Клиника кардиологии кардиохирургии
Armenia

Competing Interests: No.


S. A. Avetisian
ЕГМУ; Медицинский центр Эребуни, Клиника кардиологии кардиохирургии
Armenia

Competing Interests: No.


M. E. Levin
ГБУЗ ПКБ № 4 им. П.Б. Ганнушкина ДЗМ
Russian Federation

Competing Interests: No.


O. V. Karpov
ГБУЗ ПКБ № 4 им. П.Б. Ганнушкина ДЗМ
Russian Federation

Competing Interests: No.


F. M. Sokhova
ГБУЗ ПКБ № 4 им. П. Б. Ганнушкина ДЗМ
Russian Federation

Competing Interests: No.


L. A. Burygina
ГБУЗ ПКБ № 4 им. П.Б. Ганнушкина ДЗМ
Russian Federation

Competing Interests: No.


T. V. Sheshina
ГБУЗ НО Городская клиническая больница № 5 Нижегородского района
Russian Federation

Competing Interests: No.


A. A. Tiurin
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


O. Yu. Dolgikh
ГБУЗ СО ЧСГБ
Russian Federation

Competing Interests: No.


E. V. Kazymova
ЧУЗ КБ на станции Самара “РЖД Медицина”
Russian Federation

Competing Interests: No.


D. Yu. Konstantinov
СамГМУ МЗ РФ
Russian Federation

Competing Interests: No.


O. A. Chumakova
Самарская городская поликлиника № 3
Russian Federation

Competing Interests: No.


O. V. Kondriakova
СамГМУ МЗ РФ
Russian Federation

Competing Interests: No.


K. Yu. Shishkov
СамГМУ МЗ РФ
Russian Federation

Competing Interests: No.


T. S. Fil
СЗГМУ им. Мечникова
Russian Federation

Competing Interests: No.


N. A. Prokofeva
СЗГМУ им. Мечникова
Russian Federation

Competing Interests: No.


M. P. Konoval
СЗГМУ им. Мечникова
Russian Federation

Competing Interests: No.


A. A. Simonov
СЗГМУ им. Мечникова
Russian Federation

Competing Interests: No.


A. M. Bitieva
СЗГМУ им. Мечникова
Russian Federation

Competing Interests: No.


N. A. Trostianetckaia
СЗГМУ им. Мечникова
Russian Federation

Competing Interests: No.


M. B. Cholponbaeva
Национальный центр кардиологии и терапии им. М.М. Миррахимова
Kyrgyzstan

Competing Interests: No.


Zh. B. Kerimbekova
Национальный центр кардиологии и терапии им. М.М. Миррахимова
Kyrgyzstan

Competing Interests: No.


M. Y. Duyshobayev
Национальный центр кардиологии и терапии им. М.М. Миррахимова
Kyrgyzstan

Competing Interests: No.


A. Ch. Akunov
Национальный центр кардиологии и терапии им. М.М. Миррахимова
Kyrgyzstan

Competing Interests: No.


N. A. Kushubakova
Национальный центр кардиологии и терапии им. М.М. Миррахимова
Kyrgyzstan

Competing Interests: No.


E. S. Melnikov
СЗГМУ им. Мечникова
Russian Federation

Competing Interests: No.


E. S. Kim
ГАУЗ ГКБ № 7
Russian Federation

Competing Interests: No.


S. Y. Sherbakov
КГМА
Russian Federation

Competing Interests: No.


D. A. Trofimov
ГАУЗ ГКБ № 7
Russian Federation

Competing Interests: No.


D. S. Evdokimov
СЗГМУ им. Мечникова
Russian Federation

Competing Interests: No.


D. A. Ayipova
Национальный центр кардиологии и терапии им. М.М. Миррахимова
Kyrgyzstan

Competing Interests: No.


I. A. Duvanov
РНИМУ им. Н.И. Пирогова
Russian Federation

Competing Interests: No.


A. K. Abdrahmanova
КазНМУ им. С.Д. Асфендиярова
Kazakhstan

Competing Interests: No.


G. T. Aimakhanova
КазНМУ им. С.Д. Асфендиярова
Kazakhstan

Competing Interests: No.


Sh. O. Ospanova
КазНМУ им. С.Д. Асфендиярова
Kazakhstan

Competing Interests: No.


G. M. Dabylova
КазНМУ им. С.Д. Асфендиярова
Kazakhstan

Competing Interests: No.


A. T. Tursunova
КазНМУ им. С.Д. Асфендиярова
Kazakhstan

Competing Interests: No.


D. S. Xaskaeva
КГМУ им. проф. В.Ф. Войно-Ясенецкого
Russian Federation

Competing Interests: No.


A. A. Tulichev
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


E. Yu. Ashina
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


V. A. Kordukova
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


O. Yu. Barisheva
ПетрГУ
Russian Federation

Competing Interests: No.


K. E. Egorova
ГБУЗ РК Республиканская больница им. В.А. Баранова
Russian Federation

Competing Interests: No.


D. D. Varlamova
ПетрГУ
Russian Federation

Competing Interests: No.


T. V. Kuprina
ПетрГУ
Russian Federation

Competing Interests: No.


E. V. Pahomova
ГБУЗ РК Республиканский Противотуберкулезный Диспансер; ПетрГУ
Russian Federation

Competing Interests: No.


N. Yu. Kurchugina
СамГМУ МЗ РФ
Russian Federation

Competing Interests: No.


I. A. Frolova
Приволжский окружной медицинский центр ФМБА России
Russian Federation

Competing Interests: No.


K. V. Mazalov
Приволжский окружной медицинский центр ФМБА России
Russian Federation

Competing Interests: No.


A. K. Subbotin
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


N. A. Kamardina
Приволжский окружной медицинский центр ФМБА России
Russian Federation

Competing Interests: No.


N. V. Zarechnova
Приволжский окружной медицинский центр ФМБА России
Russian Federation

Competing Interests: No.


E. M. Mamutova
Национальный медицинский исследовательский центр терапии и профилактической медицины МЗ РФ
Russian Federation

Competing Interests: No.


L. A. Smirnova
РНИМУ им. Н.И. Пирогова
Russian Federation

Competing Interests: No.


A. V. Klimova
ГБУЗ ГП 134 ДЗМ; РНИМУ им. Н.И. Пирогова
Russian Federation

Competing Interests: No.


L. D. Shakhgildyan
РНИМУ им. Н.И. Пирогова
Russian Federation

Competing Interests: No.


D. S. Tokmin
АО “Лаборатории Будущего”
Russian Federation

Competing Interests: No.


D. I. Tupitsin
ООО МЦ “Петровские Ворота”
Russian Federation

Competing Interests: No.


T. V. Kriukova
Евразийская Ассоциация Терапевтов
Russian Federation

Competing Interests: No.


N. A. Rakov
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


D. S. Polyakov
ПИМУ МЗ РФ
Russian Federation

Competing Interests: No.


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Arutyunov G.P., Tarlovskaya E.I., Arutyunov A.G., Belenkov Y.N., Konradi A.O., Lopatin Y.M., Tereshchenko S.N., Rebrov A.P., Chesnikova A.I., Fomin I.V., Grigorieva N.V., Boldina M.V., Vaisberg A.R., Blagonravova A.S., Makarova E.V., Shaposhnik I.I., Kuznetsova T.Yu., Malchikova S.V., Protsenko D.N., Evzerikhina A.V., Petrova M.M., Demko I.V., Saphonov D.V., Hayrapetyan H.G., Galyavich A.S., Kim Z.F., Sugraliev A.B., Nedogoda S.V., Tsoma V.V., Sayganov S.A., Gomonova V.V., Gubareva I.V., Sarybaev A.Sh., Koroleva E.V., Vilkova O.E., Fomina I.Y., Pudova I.A., Soloveva D.V., Kiseleva N.V., Zelyaeva N.V., Kouranova I.M., Pogrebetskaya V.A., Muradova F.N., Badina O.Y., Kovalishena O.V., Galova E.A., Plastinina S.S., Lyubavina N.A., Vezikova N.N., Levankova V.I., Ivanova S.Yu., Ermilova A.N., Muradyan R.G., Gostishev R.V., Tikhonova E.P., Kuzmina T.Y., Soloveva I.A., Kraposhina A.Yu., Kolyadich M.I., Kolchinskaya T.P., Genkel V.V., Kuznetsova A.S., Kazakovtseva M.V., Odegova A.A., Chudinovskikh T.I., Baramzina S.V., Rozanova N.A., Kerimova A.Sh., Krivosheina N.A., Chukhlova S.Y., Levchenko A.A., Avoyan H.G., Azarian K.K., Musaelian Sh.N., Avetisian S.A., Levin M.E., Karpov O.V., Sokhova F.M., Burygina L.A., Sheshina T.V., Tiurin A.A., Dolgikh O.Yu., Kazymova E.V., Konstantinov D.Yu., Chumakova O.A., Kondriakova O.V., Shishkov K.Yu., Fil T.S., Prokofeva N.A., Konoval M.P., Simonov A.A., Bitieva A.M., Trostianetckaia N.A., Cholponbaeva M.B., Kerimbekova Zh.B., Duyshobayev M.Y., Akunov A.Ch., Kushubakova N.A., Melnikov E.S., Kim E.S., Sherbakov S.Y., Trofimov D.A., Evdokimov D.S., Ayipova D.A., Duvanov I.A., Abdrahmanova A.K., Aimakhanova G.T., Ospanova Sh.O., Dabylova G.M., Tursunova A.T., Xaskaeva D.S., Tulichev A.A., Ashina E.Yu., Kordukova V.A., Barisheva O.Yu., Egorova K.E., Varlamova D.D., Kuprina T.V., Pahomova E.V., Kurchugina N.Yu., Frolova I.A., Mazalov K.V., Subbotin A.K., Kamardina N.A., Zarechnova N.V., Mamutova E.M., Smirnova L.A., Klimova A.V., Shakhgildyan L.D., Tokmin D.S., Tupitsin D.I., Kriukova T.V., Rakov N.A., Polyakov D.S. International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV SARS-CoV-2): analysis of 1,000 patients. Russian Journal of Cardiology. 2020;25(11):4165. https://doi.org/10.15829/29/1560-4071-2020-4165

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