Prognostic value of neutrophil gelatinase-associated lipocalin and cystatin C in patients with heart failure and previous myocardial infarction
https://doi.org/10.15829/1560-4071-2021-4126
Abstract
Aim. To study the prognostic value of neutrophil gelatinase-associated lipocalin (NGAL or lipocalin-2) and cystatin C in patients with heart failure (HF) and myocardial infarction (MI).
Material and methods. Baseline plasma concentrations of NGAL and cystatin C were measured in 119 participants (median age, 50-61 years; men, 101) with HF and primary MI (4-6 weeks old) who underwent percutaneous coronary intervention in the acute period. Adverse cardiovascular events within 1 year were considered as the endpoint.
Results. Patients with elevated NGAL levels were significantly more likely to have adverse events (p<0,001). The optimal cut-off value for NGAL was 18,75 ng/ml (odds ratio, 10, 95% CI, 3,09-32,45; p=0,0001). Multivariate logistic regression showed that NGAL, N-terminal pro-brain natriuretic peptide, left ventricular aneurysm, and SYNTAX score were significant predictors of adverse events. Cystatin C did not affect prognosis in the study cohort.
Conclusion. Increased NGAL levels is a predictor of unfavorable clinical outcome in patients with HF and previous MI.
Supporting agencies: The study was carried out as part of R&D at the Samara State Medical University
About the Authors
N. V. Kompanets
Samara State Medical University
Russian Federation
Competing Interests: not
Russian Federation
Competing Interests: not
Yu. V. Shchukin
Samara State Medical University
Russian Federation
Competing Interests: not
Russian Federation
Competing Interests: not
L. V. Limareva
Samara State Medical University
Russian Federation
Competing Interests: not
Russian Federation
Competing Interests: not
M. V. Komarova
Samara State Medical University; Samara National Research University
Russian Federation
Competing Interests: not
Russian Federation
Competing Interests: not
References
1. The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Russ J Cardiol. 2017;141(1):7-81. (In Russ.) doi:10.15829/1560-4071-2017-1-7-81.
2. Ronco C, Bellasi A, Di Lullo L. Cardiorenal Syndrome: An Overview. Adv Chronic Kidney Dis. 2018;25(5):382-90. doi:10.1053/j.ackd.2018.08.004.
3. Zannad F, Rossignol P. Cardiorenal Syndrome Revisited. Circulation. 2018;138(9):929-44. doi:10.1161/CIRCULATIONAHA.117.028814.
4. van Veldhuisen DJ, Ruilope LM, Maisel AS, et al. Biomarkers of renal injury and function: diagnostic, prognostic and therapeutic implications in heart failure. Eur Heart J. 2016;37(33):2577-85. doi:10.1093/eurheartj/ehv588.
5. Nikiforova TA, Shchekochikhin DYu, Kopylov FYu, et al. Prognostic value of biomarkers in chronic heart failure with preserved left ventricular ejection fraction. Ter Arkh. 2016;88(9):102-5. (In Russ.) doi:10.17116/terarkh2016889102-105.
6. Sivalingam Z, Larsen SB, Grove EL, et al. Neutrophil gelatinase-associated lipocalin as a risk marker in cardiovascular disease. Clin Chem Lab Med. 2017;56(1):5-18. doi:10.1515/cclm-2017-0120.
7. Bachorzewska-Gajewska H, Tomaszuk-Kazberuk A, Jarocka I, et al. Does Neutrophil Gelatinase-Asociated Lipocalin Have Prognostic Value in Patients with Stable Angina Undergoing Elective PCI? A 3-Year Follow-Up Study. Kidney Blood Press Res. 2013;37(4-5):280-5. doi:10.1159/000350155.
8. Ito M, Doi K, Takahashi M, et al. Plasma neutrophil gelatinase-associated lipocalin predicts major adverse cardiovascular events after cardiac care unit discharge. J Cardiol. 2016;67(2):184-91. doi:10.1016/j.jjcc.2015.05.010.
9. Brankovic M, Akkerhuis KM, van Boven N, et al. Patient-specific evolution of renal function in chronic heart failure patients dynamically predicts clinical outcome in the Bio-SHiFT study. Kidney Int. 2018;93(4):952-60. doi:10.1016/j.kint.2017.09.013.
10. Kunutsor SK, Flores-Guerrero JL, Kieneker LM, et al. Plasma neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease: Findings from the PREVEND prospective cohort study. Clin Chim Acta. 2018;486:66-75. doi:10.1016/j.cca.2018.07.034.
11. Labr K, Spinar J, Parenica J, et al. Renal functions and prognosis stratification in chronic heart failure patients and the importance of neutrophil gelatinase-associated lipocalin. Kidney Blood Press Res. 2018;43(6):1865-77. doi:10.1159/000495819.
12. Chong JJH, Prince RL, Thompson PL, et al. Association between plasma neutrophil gelatinase-associated lipocalin and cardiac disease hospitalizations and deaths in older women. J Am Heart Assoc. 2019;8(1):e011028. doi:10.1161/JAHA.118.011028.
13. Brankovic M, Akkerhuis KM, Buljubasic N, et al. Plasma cystatin C and neutrophil gelatinase-associated lipocalin in relation to coronary atherosclerosis on intravascular ultrasound and cardiovascular outcome: Impact of kidney function (ATHEROREMO-IVUS study). Atherosclerosis. 2016;254:20-7. doi:10.1016/j.atherosclerosis.2016.09.016.
14. Soylu K, Aksan G, Nar G, et al. Serum neutrophil gelatinase-associated lipocalin levels are correlated with the complexity and the severity of atherosclerosis in acute coronary syndrome. Anatol J Cardiol. 2015;15(16):450-5. doi:10.5152/akd.2014.5513.
15. Nymo SH, Ueland T, Askevold ET, et al. The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA. J Intern Med. 2012;271(5):436-43. doi:10.1111/j.1365-2796.2011.02503.x.
16. Karetnikova VN, Osokina AV, Evseeva MV, et al. Renal function estimation formulas in predicting long-term cardiovascular outcomes in patients with myocardial infarction concurrent with diabetes mellitus. Ter Arkh. 2016;88(4):35-40. (In Russ.) oi:10.17116/terarkh201688435-40.
17. Zamora E, Lupon J, de Antonio M, et al. Long-term Prognostic Value for Patients with Chronic Heart Failure of Estimated Glomerular Filtration Rate Calculated with the New CKD-EPI Equations Containing Cystatin C. Clin Chem. 2014;60(3):481-9. doi:10.1373/clinchem.2013.212951.
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For citations:
Kompanets N.V., Shchukin Yu.V., Limareva L.V., Komarova M.V. Prognostic value of neutrophil gelatinase-associated lipocalin and cystatin C in patients with heart failure and previous myocardial infarction. Russian Journal of Cardiology. 2021;26(1):4126. (In Russ.) https://doi.org/10.15829/1560-4071-2021-4126
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