Терапия внеклеточными везикулами: возможности, механизмы и перспективы применения
https://doi.org/10.15829/1560-4071-2020-4081
Аннотация
Внеклеточные везикулы – биологические мембранные объекты, имеющие размеры менее 1000 нм, транспортирующие многие биологически активные молекулы (белки, микроРНК, мРНК, ДНК и т.д.), а также способные выполнять многие биологические функции и обеспечивать межклеточные взаимодействия. В настоящее время активно изучаются возможности их терапевтического применения при различных патологических состояниях и заболеваниях. В большинстве случаев в качестве клеточного источника внеклеточных везикул рассматриваются мезенхимальные стволовые клетки, а реализуемые терапевтические эффекты связывают с переносимыми микроРНК. В in vitro исследованиях показано, что внутриклеточные везикулы могут стимулировать регенерацию и ангиогенез, оказывать противовоспалительное, противоапоптотическое действие. Проводимые исследования, рассмотренные и структурированные нами в данном обзоре, демонстируют перспективы клинического применения внеклеточных везикул в терапии таких патологических состояний как окислительный стресс, ишемическое и реперфузионное повреждение тканей и органов, опухолевый рост и т.д.
При поддержке: Исследование выполнено за счет гранта Российского научного фонда (проект № 19-75-20076).
Об авторах
Ф. С. Великонивцев
Национальный медицинский исследовательский центр им. В.А. Алмазова
Россия
Россия
Федор Сергеевич Великонивцев — студент Института Медицинского образования Центра Алмазова
ResearcherID: AAY-4886-2020
Санкт-Петербург
А. С. Головкин
Национальный медицинский исследовательский центр им. В.А. Алмазова
Россия
Россия
Алексей Сергеевич Головкин — руководитель группы генно-клеточной инженерии Института молекулярной биологии и генетики,
ResearcherID: I-2583-2014
Санкт-Петербург
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Рецензия
Для цитирования:
Великонивцев Ф.С., Головкин А.С. Терапия внеклеточными везикулами: возможности, механизмы и перспективы применения. Российский кардиологический журнал. 2020;25(10):4081. https://doi.org/10.15829/1560-4071-2020-4081
For citation:
Velikonivtsev F.S., Golovkin A.S. Extracellular vesicles therapy: opportunities, mechanisms and perspectives. Russian Journal of Cardiology. 2020;25(10):4081. (In Russ.) https://doi.org/10.15829/1560-4071-2020-4081
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