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Терапия внеклеточными везикулами: возможности, механизмы и перспективы применения

https://doi.org/10.15829/1560-4071-2020-4081

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Аннотация

Внеклеточные везикулы – биологические мембранные объекты, имеющие размеры менее 1000 нм, транспортирующие многие биологически активные молекулы (белки, микроРНК, мРНК, ДНК и т.д.), а также способные выполнять многие биологические функции и обеспечивать межклеточные взаимодействия. В настоящее время активно изучаются возможности их терапевтического применения при различных патологических состояниях и заболеваниях. В большинстве случаев в качестве клеточного источника внеклеточных везикул рассматриваются мезенхимальные стволовые клетки, а реализуемые терапевтические эффекты связывают с переносимыми микроРНК. В in vitro исследованиях показано, что внутриклеточные везикулы могут стимулировать регенерацию и ангиогенез, оказывать противовоспалительное, противоапоптотическое действие. Проводимые исследования, рассмотренные и структурированные нами в данном обзоре, демонстируют перспективы клинического применения внеклеточных везикул в терапии таких патологических состояний как окислительный стресс, ишемическое и реперфузионное повреждение тканей и органов, опухолевый рост и т.д.

Об авторах

Ф. С. Великонивцев
Национальный медицинский исследовательский центр им. В.А. Алмазова
Россия

Федор Сергеевич Великонивцев — студент Института Медицинского образования Центра Алмазова

ResearcherID: AAY-4886-2020

Санкт-Петербург



А. С. Головкин
Национальный медицинский исследовательский центр им. В.А. Алмазова
Россия

Алексей Сергеевич Головкин — руководитель группы генно-клеточной инженерии Института молекулярной биологии и генетики,

ResearcherID: I-2583-2014

Санкт-Петербург



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Для цитирования:


Великонивцев Ф.С., Головкин А.С. Терапия внеклеточными везикулами: возможности, механизмы и перспективы применения. Российский кардиологический журнал. 2020;25(10):4081. https://doi.org/10.15829/1560-4071-2020-4081

For citation:


Velikonivtsev F.S., Golovkin A.S. Extracellular vesicles therapy: opportunities, mechanisms and perspectives. Russian Journal of Cardiology. 2020;25(10):4081. (In Russ.) https://doi.org/10.15829/1560-4071-2020-4081

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ISSN 1560-4071 (Print)
ISSN 2618-7620 (Online)