Methoxy polyethylene glycol epoetin beta and the treatment of anaemia in chronic heart failure
https://doi.org/10.15829/1560-4071-2013-3-74-80
Abstract
Aim. To study erythropoietic activity and safety of methoxy polyethylene glycol epoetin beta (MEB) and its effects on haemoglobin (Hb), erythropoietin, ferritin, NT-proBNP, cytokines, and chronic heart failure (CHF) symptoms and signs.
Material and methods. In total, 84 patients with Functional Class (FC) II–IV (NYHA) CHF and anaemia were examined (mean age 59,7±1,6 years; 54 men and 30 women). Anaemia criteria were Hb levels <120 g/l in men and <110 g/l in women. CHF was due to coronary heart disease, CHD (post-infarction cardiosclerosis; n=40); to CHD in combination with Type 2 diabetes mellitus, DM-2 (n=10), and arterial hypertension, AH (n=14); and to the combination of CHD, AH, and DM-2 (n=10). Left ventricular ejection fraction (LVEF) in CHF patients with FC II, III, and IV was
About the Authors
K. Kh. Zakhidova
A. Aliev Azerbaijani State Institute of Post-diploma Medical Education, Cardiology Department, Baku, Azerbaijan
Azerbaijan
Azerbaijan
F. A. Kuliev
A. Aliev Azerbaijani State Institute of Post-diploma Medical Education, Cardiology Department, Baku, Azerbaijan
Azerbaijan
Azerbaijan
References
1. Stamos T. D. Silver M. A. Management of anemia in heart failure. Curr Opin Cardiol 2010; 25:148–54.
2. Silverberg D. S., Wexler D., Blum M. et al. The effect of correction of anemia in diabetic and non diabetics with severe resistant congestive heart failure and chronic renal failure by subcutaneus erythropoietin and intravenous iron. Nephrol Dial Transplant 2003; 18:141–6.
3. He S. W., Wang L. X. The impact of anemia of the prognosis chronic heart failure: a metaanalysis and systemic review. Congest Heart Failure 2009; 15 (3):123–30.
4. Suenivas Ivengar M. D., William T., Abraham M. D. Anemia in chronic heart failure: Can EPO reduce death? Cleveland clinic journal of medicine 2005; 72 (11):1027–32.
5. Yankowska E. A., Rozentryt P., Witkowska A. et al. Iron deficiency: an ominous sign in patients with systolic chronic heart failure. Eur Heart J. 2010; 31 (15): 1872–6.
6. Silvenberg D. S., Wexler D., Blum M. et al. The cardio renal anemia syndrome: correcting anemia in patients with resistant congestive heart failure can improve both cardiac and renal functional and reduce hospitalizations. Clin. Nephrol 2003; 60 (1):93–102.
7. Silverberg D. S., Wexler D., Iaing A. et al. Correction of iron deficiency in the cardio renal syndrome Int. J. Nephrol 2011;365: p.301
8. Gorg J., Patal S., Wexler D. et al. Circulating erythropoietin levels and prognosis in patients with congestive heart failure: comparison with neurohormonal and inflammatory markers. Arch Intern Med 2005 Jun13; 165 (11):1304–9.
9. Torre-Amione G., Bourge R., Colucci S. W. et al. A study to assess the effects of a broadspectrum immune modulatory therapy on mortality and morbidity in patients with chronic heart failure: the ACCLAIM trial rationale and design. Canad j cardiol. 2007; 23 (5):369–76.
10. Teplyakov A. T., Dibirov M. M., Bolotskaya L. A. The modulatory effect of carvedilol on cytokines activation and regress of heart failure in patients with postinfaction disfunction of heart. Cardiology 2004; 9:50–7. Russian (Тепляков А. Т., Дибиров М. М., Болотская Л. А. Модулирующее влияние карведилола на активацию цитокинов и регресс сердечной недостаточности у больных с постинфарктной дисфункцией
11. сердца. Кардиология 2004; 9:50–7).
Review
For citations:
Zakhidova K.Kh., Kuliev F.A. Methoxy polyethylene glycol epoetin beta and the treatment of anaemia in chronic heart failure. Russian Journal of Cardiology. 2013;(3):74-80. (In Russ.) https://doi.org/10.15829/1560-4071-2013-3-74-80
Views:
878
Email this article 