Preview

Russian Journal of Cardiology

Advanced search

Angiotensin II and COVID-19. Secrets of interactions

https://doi.org/10.15829/1560-4071-2020-3861

Abstract

The article describes current data on the relationship of renin-angiotensin system and related drugs with the risk of COVID-19 infection and its outcomes. Analysis of the latest publications did not reveal association of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with any risk of an unfavorable outcomes, and there was no data for withdrawal of these drugs.

About the Authors

A. O. Konradi
Almazov National Medical Research Center
Russian Federation
St. Petersburg


A. O. Nedoshivin
Almazov National Medical Research Center
Russian Federation
St. Petersburg


References

1. HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID19. https://www.acc.org/latest-in-cardiology/articles/2020/03/17/08/59/hfsa-acc-ahastatement-addresses-concerns-re-using-raas-antagonists-in-covid-19.

2. ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. last updated on 21 April 2020, https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance

3. Shlyakho EV, Konradi AO, Arutyunov GP, et al. Guidelines for the diagnosis and treatment of circulatory diseases in the context of the COVID-19 pandemic. Russian Journal of Cardiology. 2020;25(3):3801. (In Russ.) doi:10.15829/1560-4071-2020-3-3801.

4. Santos RAS, Sampaio WO, Alzamora AC, et al. The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7). Physiol Rev. 2018;98(1):505- 53. doi:10.1152/physrev.00023.2016.

5. Ferrario CM, Jessup J, Chappell MC, et al. Effect of angiotensin‐converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin‐converting enzyme 2. Circulation. 2005;111(20):2605-10. doi:10.1161/CIRCULATIONAHA.104.510461. Epub 2005 May 16.

6. Sommerstein R, Gräni C. Rapid response: re: preventing a covid‐19 pandemic: ACE inhibitors as a potential risk factor for fatal Covid‐19. BMJ 2020; 368. doi:10.1136/bmj.m810.

7. Esler M, Esler D. Can angiotensin receptor-blocking drugs perhaps be harmful in the COVID19 pandemic? J Hypertens. 2020;38(5):781-2. doi:10.1097/HJH.0000000000002450.

8. Hamming I, Timens W, Bulthuis ML, et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203(2):631-7. doi:10.1002/path.1570.

9. Wu Y. Compensation of ACE2 Function for Possible Clinical Management of 2019-nCoVInduced Acute Lung Injury. Virol Sin. 2020. doi:10.1007/s12250-020-00205-6. Online ahead of print.

10. Guang Ya, Zihu T, Ling Z, et al. Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors Usage is Associated with Improved Inflammatory Status and Clinical Outcomes in COVID-19 Patients With Hypertension. doi:10.1101/2020.03.31.20038935.

11. Vaduganathan M, Vardeny O, Michel T, et al. Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19. NEJM. 2020;382(17):1653-9. doi:10.1056/NEJMsr2005760.

12. Sommerstein R, Kochen MM, Messerli FH, Gräni Ch. Coronavirus Disease 2019 (COVID‐19): Do Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers Have a Biphasic Effect? J Am Heart Assoc. 2020;9(7):e016509. doi:10.1161/JAHA.120.016509.

13. Khan A, Benthin C, Zeno B, et al. A pilot clinical trial of recombinant human angiotensinconverting enzyme 2 in acute respiratory distress syndrome. Crit Care. 2017;21(1):234. doi:10.1186/s13054-017-1823-x.

14. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054- 62. doi:10.1016/S0140-6736(20)30566-3.

15. Juyi Li, Wang X, Chen J, et al. Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China. JAMA Cardiol. 2020. doi:10.1001/jamacardio.2020.1624.

16. Zoler ML. ACEI/ARBs Linked With Survival in Hypertensive, Chinese COVID-19 Patients Medscape. Medical News April 22. 2020.

17. Gurwitz D. Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics. Drug Dev Res. 2020. doi:10.1002/ddr.21656. Online ahead of print.


Review

For citations:


Konradi A.O., Nedoshivin A.O. Angiotensin II and COVID-19. Secrets of interactions. Russian Journal of Cardiology. 2020;25(4):3861. (In Russ.) https://doi.org/10.15829/1560-4071-2020-3861

Views: 3768


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1560-4071 (Print)
ISSN 2618-7620 (Online)