The effect of sex and age hormonal changes on the development of heart failure
https://doi.org/10.15829/1560-4071-2020-3710
Abstract
Currently, there is an increase in the incidence of cardiac disease in the elderly. Both the morbidity and progression rate differ in different age and sex groups. Agerelated cardiovascular changes can also be associated with the influence of sex hormones both on the myocardium itself and on the signaling involved in the regulation of circulation. Estrogen affects the mechanisms of vasodilation, the relationship of hypoxia and angiogenesis, the development of left ventricular diastolic dysfunction. Therefore, estrogen deficiency is a risk factor for cardiovascular diseases. An increase in the androgen level is involved in pathophysiological mechanisms such as aging, heart failure, and vascular remodeling. Many studies have demonstrated the inverse relationship between sex hormone levels and cardiovascular risk, morbidity and mortality. However, efforts to control the natural hormonal changes show mixed results. Additional prospective studies are needed to clarify the roles of various sex hormones in initiating cardiovascular disease and cardiac failure itself, as well as evaluating the effectiveness of hormone therapy in patients with cardiovascular disease.
About the Authors
E. K. Serezhina
OOO International Medical Center SOGAZ
Russian Federation
Russian Federation
St. Petersburg
A. G. Obrezan
OOO International Medical Center SOGAZ
Russian Federation
Russian Federation
St. Petersburg
References
1. Savarese G, Lundcor LH. Global Public Health Burden of Heart Failure Card Fail Rev. 2017;3(1):7-11. doi:10.15420/cfr.2016:25:2.
2. Eng J, McClelland RL, Gomes AS, et al. Adverse Left Ventricular Remodeling and Age Assessed with Cardiac MR Imaging: The Multi-Ethnic Study of Atherosclerosis. Radiology. 2016;278(3):714-22. doi:10.1148/radiol.2015150982.
3. Cheng S, Xanthakis V, Sullivan LM, et al. Correlates of echocardiographic indices of cardiac remodeling over the adult life course: longitudinal observations from the Framingham Heart Study. Circulation. 2010;122:570-8. doi:10.1161/CIRCULATIONAHA.110.937821.
4. Gori M, Lam CS, Gupta DK, et al. Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction. Eur J Heart Fail. 2014;16:535-42. doi:10.1002/ejhf.67.
5. Yoneyama K, Gjesdal O, Choi EY, et al. Age, sex, and hypertension-related remodeling influences left ventricular torsion assessed by tagged cardiac magnetic resonance in asymptomatic individuals: the multi-ethnic study of atherosclerosis. Circulation. 2012;126:2481-90. doi:10.1161/CIRCULATIONAHA.112.093146.
6. Tadic M, Cuspidi C, Plein S, et al. Sex and Heart Failure with Preserved Ejection Fraction: From Pathophysiology to Clinical Studies. J Clin Med. 2019;8(6):792. doi:10.3390/jcm8060792.
7. Beale AL, Nanayakkara S, Kaye DM. Impact of Sex on Ventricular‐Vascular Stiffness and Long‐Term Outcomes in Heart Failure With Preserved Ejection Fraction: TOPCAT Trial Substudy. J Am Heart Assoc. 2019;8(13):e012190. doi:10.1161/JAHA.119.012190.
8. Joshi H, Edgell H. Sex differences in the ventilatory and cardiovascular response to supine and tilted metaboreflex activation. Physiol Rep. 2019;7(6):e14041. doi:10.14814/phy2.14041.
9. Zhang B, Miller VM, Miller JD. Influences of Sex and Estrogen in Arterial and Valvular Calcification. Front Endocrinol (Lausanne). 2019;10:622. doi:10.3389/fendo.2019.00622.
10. Sangiorgi G, Roversi S, Biondi G, et al. Sex-related differences in carotid plaque features and inflammation. Journal of Vascular Surgery. 2013;57:338-44. doi:10.1016/j.jvs.2012.07.052.
11. Ota H, Reeves MJ, Zhu DC, et al. Sex differences in patients with asymptomatic carotid atherosclerotic plaque: in vivo 3. 0-T magnetic resonance study. Stroke. 2010;41:1630-5. doi:10.1161/STROKEAHA.110.581306.
12. Zhao D, Guallar E, Ouyang P, et al. Endogenous Sex Hormones and Incident Cardiovascular Disease in Post-Menopausal Women. J Am Coll Cardiol. 2018;71(22):2555-66. doi:10.1016/j.jacc.2018.01.083.
13. Nevzati E, Shafighi M, Bakhtian KD, et al. Estrogen induces nitric oxide production via nitric oxide synthase activation in endothelial cells. Neurovascular Events After Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement. Springer, Cham. 2014;120. doi:10.1007/978-3-319-04981-6_24.
14. Fandino J, Marbacher S, Fathi A-R, et al. Neurovascular Events After Subarachnoid Hemorrhage. Cham: Springer International Publishing; 2015. p. 141-5. ISBN 978-3-319-04981-6.
15. Barnabas O, Wang H, Gao X-M. Role of estrogen in angiogenesis in cardiovascular diseases. J Geriatr Cardiol. 2013;10:377-82. doi:10.3969/j.issn.1671-5411.2013.04.008.
16. Jeansson M, Gawlik A, Anderson G, et al. Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest. 2011;121:2278-89. doi:10.1172/JCI46322.
17. Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008;22:1276-312. doi:10.1101/gad.1653708.
18. Dobaczewski M, Chen W, Frangogiannis NG. Transforming growth factor (TGF)-β signaling in cardiac remodeling. J Mol Cell Cardiol. 2011;51:600-6. doi:10.1016/j.yjmcc.2010.10.033.
19. Lam CSP, Cheng S, Choong K, et al. Influence of Sex and Hormone Status on Circulating natriuretic Peptides. J Am Coll Cardiol. 2011;58:618-26. doi:10.1016/j.jacc.2011.03.042.
20. Nadir MA, Rekhraj S, Wei L, et al. Improving the primary prevention of cardiovascular events by using biomarkers to identify individuals with silent heart disease. J Am Coll Cardiol. 2012;60(11):960-8. doi:10.1016/j.jacc.2012.04.049.
21. Nambi V, Liu X, Chambless LE, et al. Troponin T and N-terminal pro-B-type natriuretic peptide: a biomarker approach to predict heart failure risk-the atherosclerosis risk in communities study. Clin Chem. 2013;59(12):1802-10. doi:10.1373/clinchem.2013.203638.
22. Linssen GC, Bakker SJ, Voors AA, et al. N-terminal pro-B-type natriuretic peptide is an independent predictor of cardiovascular morbidity and mortality in the general population. Eur Heart J. 2010;31(1):120-7. doi:10.1093/eurheartj/ehp420.
23. Ebong I, Watson K, Goff D, et al. Association of menopause age and N-terminal pro brain natriuretic peptide: the Multi-Ethnic Study of Atherosclerosis. Menopause. 2015;22(5):527-33. doi:10.1097/GME.0000000000000342.
24. Kallen A, Pal L. Cardiovascular disease and Ovarian function. Curr Opin Obstet Gynecol. 2011;23:258-67. doi:10.1097/GCO.0b013e3283488a21.
25. Ebong IA, Watson KE, Goff DC, et al. Age at Menopause and incident heart failure: the Multi-Ethnic Study of Atherosclerosis. Menopause. 2014;21:585-91. doi:10.1097/GME.0000000000000138.
26. Pedram A, Razandi M, Lubahn D, et al. Estrogen inhibits cardiac hypertrophy: role of estrogen receptor-β to inhibit calcineurin. Endocrinology. 2008;149:3361-9. doi:10.1210/en.2008-0133.
27. Boardman HMP, Hartley L, Eisinga A, et al. Hormone therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database Syst Rev. 2015;(3):CD002229. doi:10.1002/14651858.
28. Gerval MO, Stevenson JC. Establishing the risk related to hormone replacement therapy and cardiovascular disease in women. Clinical Pharmacist. 2017;9(1). doi:10.1211/CP.2017.20202066.
29. Manson JE, Chlebowski RT, Stefanick ML, et al. Menopausal hormone therapy and health outcomes during the intervention and extended post-stopping phases of the Women’s Health Initiative randomized trials. JAMA. 2013;310(13):1353-68. doi:10.1001/jama.2013.278040.
30. Reslan OM, Khalil RA. Vascular effects of estrogenic menopausal hormone therapy. Rev Recent Clin Trials. 2012;7(1):47-70. doi:10.2174/157488712799363253.
31. Ruige JB, Mahmoud AM, De Bacquer D, et al. Endogenous testosterone and cardiovascular disease in healthy men: A meta-analysis. Heart. 2011;97:870. doi:10.1136/hrt.2010.210757.
32. Oskui PM, French WJ, Herring MJ, et al. Testosterone and the cardiovascular system: a comprehensive review of the clinical literature. J Am Heart Assoc. 2013;2(6):e000272. doi:10.1161/JAHA.113.000272.
33. Glisica M, Rojasa LZ, Asllanaja E, et al. Sex steroids, sex hormone-binding globulin and levels of N-terminal pro-brain natriuretic peptide in postmenopausal women. International Journal of Cardiology. 2018;26:189-195. doi:10.1016/j.ijcard.2018.03.008.
34. Alex L, Russo I, Holoborodko V, et al. Characterization of a mouse model of obesityrelated fibrotic cardiomyopathy that recapitulates features of human heart failure with preserved ejection fraction. Am J Physiol Circ Physiol. 2018;315:H934-49. doi:10.1152/ajpheart.00238.2018.
35. Kong P, Christia P, Frangogiannis NG. The pathogenesis of cardiac fibrosis. Cell Mol Life Sci. 2014;71:549-74. doi:10.1007/s00018-013-1349-6.
36. Subramanya V, Zhao D, Ouyang P, et al. Sex Hormone Levels and Change in Left Ventricular Structure Among Men and Post-Menopausal Women: The Multi-Ethnic Study of Atherosclerosis (MESA). Maturitas. 2018;108:37-44. doi:10.1016/j.maturitas.2017.11.006.
37. Fortunati N, Catalano MG, Boccuzzi G, et al. Sex hormone-binding globulin (SHBG), estradiol and breast cancer, Mol. Cell. Endocrinol. 2010;316(1):86-92. doi:10.1016/j.mce.2009.09.012.
38. Yasui T, Matsui S, Saijo, A, et al. Association of N-terminal pro B-type natriuretic peptide and sex hormone-binding globulin in non-obese peri- and postmenopausal women. Clinica Chimica Acta. 2010;411(3-4):280-4. doi:10.1016/j.cca.2009.11.025.
39. Mannic T, Viguie J, Rossier MF. In Vivo and in Vitro Evidences of Dehydroepiandrosterone Protective Role on the Cardiovascular System. Int J Endocrinol Metab. 2015;13(2):e24660. doi:10.5812/ijem.24660.
40. Baird GL, Archer-Chicko C, Barr RG, et al. Lower DHEA-S levels predict disease and worse outcomes in post-menopausal women with idiopathic, connective tissue diseaseand congenital heart disease-associated pulmonary arterial hypertension. Eur Respir J. 2018;51(6):1800467. doi:10.1183/13993003.00467-2018.
41. Yoshida S, Aihara K, Azuma H, et al. Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function. Atherosclerosis. 2010;212(1):310-5. doi:10.1016/j.atherosclerosis.2010.05.011.
Review
For citations:
Serezhina E.K., Obrezan A.G. The effect of sex and age hormonal changes on the development of heart failure. Russian Journal of Cardiology. 2020;25(6):3710. (In Russ.) https://doi.org/10.15829/1560-4071-2020-3710
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