The incidence of frailty and its relationship with long-term survival in patients with heart failure and implanted cardiac resynchronization therapy devices
https://doi.org/10.15829/1560-4071-2020-3685
Abstract
Aim. To assess long-term survival depending on the presence and severity of frailty in patients with heart failure (HF) and implanted cardiac resynchronization therapy devices.
Material and methods. We examined 77 patients (men — 74%, women — 26%, mean age 58,7±10,7 years) with NYHA class II-IV HF. The follow-up period was 42,4±27,1 months. On the basis of 31 parameters (medical history, diagnostic tests, questionnaire survey of physical activity limitations), a frailty index was calculated. Depending on the index value, the patients were divided into 2 groups: group 1 (n=41) — <0,375 (no frailty), group 2 (n=36) — ≥0,375 (patients with frailty).
Results. Long-term survival of patients in group 1 was 87,8%, in group 2 — 52,8% (Log rank p<0,001). According to the univariate analysis, the presence of frailty was significantly associated with long-term mortality (odds ratio (OR) 6,108; 95% confidence interval (CI) 2,207-16,907; p<0,001). When sex, age, left ventricular ejection fraction, left bundle branch block, QRS duration, left ventricular volume were included in the multivariate analysis, the presence of frailty remained a significant predictor of long-term mortality (OR 5,763; 95% CI 1,837-18,083; p=0,003).
Conclusion. Frailty has an independent effect on the long-term all-cause death risk in patients with HF and implanted cardiac resynchronization therapy devices.
About the Authors
A. M. Soldatova
Tyumen Cardiology Research Center, branch of the Tomsk National Research Medical Center
Russian Federation
Tyumen
Russian Federation
Tyumen
V. A. Kuznetsov
Tyumen Cardiology Research Center, branch of the Tomsk National Research Medical Center
Russian Federation
Tyumen
Russian Federation
Tyumen
D. S. Bogdanova
Tyumen State Medical University
Russian Federation
Tyumen
Russian Federation
Tyumen
F. T. Benzineb
Tyumen State Medical University
Russian Federation
Tyumen
Russian Federation
Tyumen
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Review
For citations:
Soldatova A.M., Kuznetsov V.A., Bogdanova D.S., Benzineb F.T. The incidence of frailty and its relationship with long-term survival in patients with heart failure and implanted cardiac resynchronization therapy devices. Russian Journal of Cardiology. 2020;25(8):3685. (In Russ.) https://doi.org/10.15829/1560-4071-2020-3685
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