MOLECULAR-GENETIC FACTORS, ASSOCIATED WITH AORTIC STENOSIS DEVELOPMENT
https://doi.org/10.15829/1560-4071-2015-10-99-106
Abstract
Aortic stenosis (AS) is one of the most prevalent valvular heart disorders in patients older than 65 years. Regardless the studied molecular mechanisms of development and progression of the disease, surgical treatment is recently the only successful method of help. Due to lots of comorbidities of older patients, there are obstacles to recommend surgical valve replacement, even knowing an adverse prognosis of conservative treatment. Search for new approaches to earlier assessment of adverse risk factors, speed of progression of this disease, would help to evaluate the necessity of earlier treatment and could make to slow down the progression of the disease. One of directions for this — is a search for genetic markers. This review focuses on the main known molecular mechanisms and genetic markers related to them, that are associated with AS.
About the Authors
T. A. Tipteva
Central state medical Academy of the administrative Department of the President of the Russian Federation, Moscow
Russian Federation
Russian Federation
O. S. Chumakova
Central state medical Academy of the administrative Department of the President of the Russian Federation, Moscow
Russian Federation
Russian Federation
D. A. Zateyshchikov
City Clinical Hospital №51, Moscow; Central state medical Academy of the administrative Department of the President of the Russian Federation, Moscow; Federal scientific-clinical center of specialized types of clinical care and medical technologies of FMBA of Russia, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Tipteva T.A., Chumakova O.S., Zateyshchikov D.A. MOLECULAR-GENETIC FACTORS, ASSOCIATED WITH AORTIC STENOSIS DEVELOPMENT. Russian Journal of Cardiology. 2015;(10):99-106. (In Russ.) https://doi.org/10.15829/1560-4071-2015-10-99-106
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