Russian Journal of Cardiology

Advanced search

Possibilities of non-drug correction of menopausal disorders in women with metabolic syndrome: focus on prothrombogenic potential of the blood and pro-inflammatory status

Full Text:


Aim. To study the dynamics of hemostasis, markers of systemic inflammation on the background of non-drug correction of menopausal disorders in women with metabolic syndrome (MS).

Material and methods. Three hundred thirty women 45-50 years old with MS and menopausal disorders are divided into 5 groups. Basic treatment received all women. In the study group and comparison groups, the following were included in the treatment program: physiotherapy exercises, drinking balneotherapy, oral multivitamins and minerals, as well as physical factors in various combinations (vibrotherapy, chromotherapy, melotherapy, aromatherapy, aero ionotherapy). The concentration of fibrinogen, C-reactive protein (CRP), hemostasis parameters were determined in dynamics.

Results. After 6 months of use of all medical complexes with physiotherapy in patients with menopausal syndrome of mild severity, a significant increase in the level of international normalized ratio (INR) was observed from 0,99 to 1,04, fibrinogen level regressed by 14,6-15,4%, CRP by 16,3-20,5% (p<0,05). In patients with climacteric syndrome of moderate severity, the best results were achieved when using the complex with a full set of all the listed factors: an increase in the INR level from 0,97 to 1,01, a decrease in the level of fibrinogen by 14,6%, and the CRP level — by 19,6% (p<0,05).

Conclusion. Polymodal programs, including physiotherapy, improve hemostasis, provide reducing the level of inflammatory markers. In moderate climacteric disorders, the priority is given to the program with simultaneous use of vibrotherapy, chromotherapy, melotherapy, aromatherapy and aeroionotherapy.

About the Authors

R. R. Berihanova
Central Clinical Hospital of General Aviation; I. M. Sechenov First Moscow State Medical University
Russian Federation

I. A. Minenko
I. M. Sechenov First Moscow State Medical University
Russian Federation


1. Zavalishina SYu, Medvedev IN. Comparison of opportunities from two therapeutical complexes for correction of vascular hemostasis in hypertensives with metabolic syndrome. Cardiovascular Therapy and Prevention. 2017;16(2):15-21. (In Russ.) doi:10.15829/1728-8800-2017-2-15-21.

2. Belenkov YuN, Privalova EV, Kaplunova VYu, et al. Metabolic Syndrome: Development of the issue, main diagnostic сriteria. Racional’naya farmakoterapiya v kardiologii. 2018;14(5):757-64. (In Russ.) doi:10.20996/1819-6446-2018-14-5-757-764.

3. Ajtbaev KA, Murkamilov IT. Obesity and metabolic syndrome: pathophysiological role of gut microbiota and potential of the alternative therapy. Kompleksnye problemy serdechnososudistyh zabolevanij. 2017;6(3):120-30. (In Russ.) doi:10.17802/2306-1278-2017-6-3-120-130.

4. Perry RJ, Peng L, Barry NA, et al. Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Nature. 2016;534:213-17. doi:10.1038/nature18309.

5. Zotova OA, Shakirova EA. Obesity and metabolic syndrome in obstetrics and gynecology. Fundamental’naya i klinicheskaya medicina. 2017;3:120-30. (In Russ.). doi:10.23946/2500-0764-2017-2-3-70-75.

6. Dobrohotova YuE, Ilyina IYu, Narimanova MR, Ibragimova DM. Metabolic syndrome in postmenopausal women. Rossijskij medicinskij zhurnal. Mat’ i ditya. 2018;1:33-8. (In Russ.) doi:10.32364/2618-8430-2018-1-1-33-38.

7. Clinical recommendations of the Ministry of health of the Russian Federation. Menopause and menopause in women. 2016. Russian society of obstetricians and gynecologists, Russian Association for menopause. (In Russ.)

8. Nikolenko LA, Alyohin DI, Nikolenko ES. Postmenopause, metabolic syndrome and ischemic heart disease (literature review). Problemy reproduktsi. 2015;21(3):117-21. (In Russ.) doi:10.17116/repro2015213117-121.

9. Recommendations of experts of the all-Russian scientific society of cardiologists on the diagnosis and treatment of metabolic syndrome (second revision) Prakticheskaya medicina. 2010;44:81-101. (In Russ.)

10. Shih EV, Mahova AA. Clinical and pharmacological aspects of using hormone-like effects of micronutrients during menopause. Medicinskij sovet. 2016;2:68-73. (In Russ.)

11. Zhernov VA, Frolkov VK, Zubarkina MM. The mechanisms underlying the therapeutic effects of reflexotherapy and drinking mineral waters in the patients presenting with metabolic syndrome. Problems of Balneology, Physiotherapy, and Exercise Therapy. Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul’tury. 2017;94(2):36-41. (In Russ.) doi:10.17116/kurort201794236-41.

12. Yakupov EhZ, Nalbat AV, Semenova MV, Tlegenova KA. Music therapy as an effective method of neurorehabilitation. Zhurnal nevrologii i psihiatrii. 2017;5:14-21. (In Russ.) doi:10.17116/jnevro20171175114-21.

13. Shutova SV. Aromaterapy: physiological effects and possible mechanisms (literature review). Tambov University Reports. Series: Natural and Technical Sciences.2013;4(1):1330-6. (In Russ.)

14. Physiotherapy and balneology. Ed. Bogolyubov VM. M.: Izdatel’skij dom BINOM, 2018. p. 408. (In Russ.) Физиотерапия и курортология. Книга I. Под ред. Боголюбова В. М. М.: Издательский дом БИНОМ, 2018. с.408. ISBN 978-5-9518-0273-6.

15. Ivanova IV. Effect of vibro-thermo-aromatherapy on seniors organism during the treatment of combined pathology of circulatory system and the musculoskeletal apparatus. Klinicheskie i fundamental’nye aspekty gerontologii. Samara: Samarskij gosudarstvennyj medicinskij universitet. 2015:160-3. (In Russ.) ISBN 978-5-91830-094-7

For citation:

Berihanova R.R., Minenko I.A. Possibilities of non-drug correction of menopausal disorders in women with metabolic syndrome: focus on prothrombogenic potential of the blood and pro-inflammatory status. Russian Journal of Cardiology. 2019;(4):53-60. (In Russ.)

Views: 571

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1560-4071 (Print)
ISSN 2618-7620 (Online)