Possible associations between recovery aerobic training and increasing the length of telomeres
https://doi.org/10.15829/1560-4071-2019-3-82-89
Abstract
It is known that in recent decades, methods of cardiac rehabilitation have been widely used in patients after acute myocardial infarction, coronary syndrome and cardiac operations. The main active factor in cardiac rehabilitation is a program of physical training. On the other hand, it has been established that physical training and/or sufficient physical activity positively affects the length of human telomeres. It is assumed that under the influence of cardiac rehabilitation, the improvement in the course of the disease may be due to an increase in telomere length. We found studies with such positive associations. This primarily concerns people with prediabetes, overweight, multiple risk factors. We established the importance of training in physically active people, athletes, especially with great sports experience. It seems promising to perform studies (training/telomeres) in patients with history of acute myocardial infarction, acute coronary syndrome and cardiac surgery.
About the Author
D. M. AronovRussian Federation
Moscow
References
1. Blackburn EH, Epel ES, Lin J. Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. Science. 2015 Dec 04;350(6265):1193-8. doi:10.1126/science.aab3389.
2. World Health Organization Series of technical reports № 270. Rehabilitation of persons with cardiovascular diseases. Geneva 1965. 62 ps. (In Russ.)
3. Werner CM, Hecksteden A, Morsch A, et al. Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study. Eur Heart J. 2018 Nov 28. doi:10.1093/eurheartj/ehy585.
4. Aviv A, Chen W, Gardner JP, et al. Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol. 2009 Feb 1;169(3):323- 9. doi:10.1093/aje/kwn338.
5. Sanders JL, Newman AB.Telomere Length in Epidemiology: A Biomarker of Aging, AgeRelated Disease, Both, or Neither? Epidemiol Rev. 2013;35(1):112-31. doi:10.1093/epirev/mxs008.
6. Denham JO, Brien BJ, Charchar FJ. Telomere Length Maintenance and CardioMetabolic Disease Prevention through Exercise Training. Sports Med.2016; 46(9):1213-37. doi:10.1007/s40279-016-0482-4.
7. Osthus IB, Sgura A, Berardinelli F, et al. Telomere length and long-term endurance exercise: does exercise training affect biological age? A pilot study. PLoS One. 2012;7(12):e52769. doi:10.1371/journal.pone.0052769.
8. LaRocca TJ, Seals DR, Pierce GL. Leukocyte Telomere Length is Preserved with Aging in Endurance Exercise-Trained Adults and Related to Maximal Aerobic Capacity. Mech Ageing Dev. 2010; 131(2):165-7. doi:10.1016/j.mad.2009.12.009.
9. Fitzpatrick AL, Kronmal RA, Kimura M, et al. Leukocyte telomere length and mortality in the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2011;66(4):421-9. doi:10.1093/gerona/glq224.
10. Ludlow AT, Zimmerman JoB, Witkowski S, et al. Relationship between physical activity level, telomere length, and telomerase activity. Med Sci Sports Exerc. 2008. Oct;40(10):1764-71. doi:10.1249/MSS.0b013e31817c92aa.
11. Cherkas LF, Aviv A, Valdes AM, et al. The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell.2006; 5(5):361-5.
12. Pollack AZ, Rivers K, Ahrens KA. Parity associated with telomere length among US reproductive age women. Hum Reprod. 2018 APR 1;33(4):736-44.
13. Steward AM, Morgan JD, Espinosa JP, et al. Chronic Pain and Telomere Length in Community-Dwelling Adults: Findings From the 1999 to 2002 National Health and Nutrition Examination Survey. J Pain. 2017;18(12):1517-25. doi:10.1016/j.jpain.2017.08.006.
14. Vidacek NS, Nanic L, Ravlic S, et al. Telomeros, Nutrition, and Longevity: Can We Really Navigate Our Aging? J Gerontol A Biol Sci Med Sci. 2017;73(1):39-47. doi:10.1093/gerona/glx082.
15. Khalangot M, Krasnienkov D, Vaiserman A, et al. Leukocyte telomere length is inversely associated with post-load but not with fasting plasma glucose levels. Exp Biol Med (Maywood). 2017;242(7):700-8. doi:10.1177/1535370217694096.
16. Sabenroth D, Meyer A, Salewsky B, et al. Sports and Exercise at Different Ages and Leukocyte Telomere Length in Later Life — Data from the Berlin Aging Study II (BASE-II). PLoS One. 2015;10(12):e0142131. doi:10.1371/journal.pone.0142131.
17. Robinson E, Durrer C, Simtchouk S, et al. Short-term high-intensity interval and moderate-intensity continuous training reduce leukocyte TLR4 in inactive adults at elevated risk of type 2 diabetes. J Appl Physiol. 2015;119(5):508-16. doi:10.1152/japplphysiol.00334.2015.
18. Aronov DM, Sharfnadel MG. Comparative evaluation of the effectiveness of various physical training methods with patients who have had a myocardial infarct. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1985;8(2):76-82. (In Russ.)
19. Goble AJ, Worcester MUC. Best practice guidelines for cardiac rehabilitation and secondary prevention: a synopsis Department of Human Services Victoria, 1999. p 273.
20. Piepoli MF, Hoes AW, Agewall S, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice. The Sixth Joint Task Force of European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted representatives of 10 societies and by invited experts). European Heart Journal. 2016;37:2315-81. doi:10.1093/eurheartj/ehw106.
21. Piercy KL, Troiano RP, Ballard RM, et al. The Physical Activity Guidelines for Americans. JAMA. Published online November 12, 2018. doi:10.1001/jama.2018.14854.
22. Baessler A, Hengstenberg C, Holmer S, et al. Long-term effects of in hospital cardiac rehabilitation on the cardiac risk profile. A case-control study in pairs of sibling with myocardial infarction. Eur. Heart J. 2001;22(13),1111-8.
Review
For citations:
Aronov D.M. Possible associations between recovery aerobic training and increasing the length of telomeres. Russian Journal of Cardiology. 2019;(3):82-89. (In Russ.) https://doi.org/10.15829/1560-4071-2019-3-82-89