Polymorphic variants of genes encoding Ca(2+)-transporting sarcoplasmic reticulum proteins in the progression of chronic heart failure
E. F. Muslimova,
T. Yu. Rebrova,
E. A. Archakov,
Sh. D. Akhmedov,
O. V. Budnikova,
R. E. Batalov,
S. A. Afanasiev https://doi.org/10.15829/1560-4071-2019-10-48-52
Abstract
Aim. To study the association between polymorphic rs1860561 variants of Ca(2+)-ATPase SERCA2a (ATP2A2) gene and rs3766871 of ryanodine receptor (RYR2) gene and the severity of chronic heart failure (CHF).
Material and methods. We determined rs1860561 and rs3766871 variants of the ATP2A2 and RYR2 genes, respectively, in 168 patients with coronary artery disease (CAD) and CHF using real-time polymerase chain reaction.
Results. A statistically significant (p=0,046) decrease in the left ventricular ejection fraction in AA homozygotes of the ATP2A2 gene compared to carriers of the G allele was shown. But among GG homozygotes, patients with FC II CHF prevailed and participants with FC I CHF were less common than among patients with genotype GA (p=0,041).
Conclusion. The association of the AA genotype carriage for the rs1860561 variant of the ATP2A2 gene encoding Ca(2+)-ATPase SERCA2a, with a decrease in the left ventricle ejection fraction in patients with CHF and CAD was revealed. At the same time, among the GG homozygotes, FC I CHF was the least prevalent. There was no association of the rY3766871 variant of the RYR2 gene with CHF severity.
Supporting agencies: This work was financially supported by the Russian Foundation for Basic Research (project № 17-04-01450)
About the Authors
E. F. Muslimova
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
PhD, Research Scientist, Laboratory of Molecular and Cellular Pathology and Gene Diagnostics
Competing Interests: not
Russian Federation
PhD, Research Scientist, Laboratory of Molecular and Cellular Pathology and Gene Diagnostics
Competing Interests: not
T. Yu. Rebrova
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
PhD, Research Scientist, Laboratory of Molecular and Cellular Pathology and Gene Diagnostics
Competing Interests: not
Russian Federation
PhD, Research Scientist, Laboratory of Molecular and Cellular Pathology and Gene Diagnostics
Competing Interests: not
E. A. Archakov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Junior Research Scientist, Department of Surgical Arrhythmology and Cardiac Pacing
Competing Interests: not
Russian Federation
Junior Research Scientist, Department of Surgical Arrhythmology and Cardiac Pacing
Competing Interests: not
Sh. D. Akhmedov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
M.D., professor, Lead Research Scientist, Department of Cardiovascular Surgery
Competing Interests: not
Russian Federation
M.D., professor, Lead Research Scientist, Department of Cardiovascular Surgery
Competing Interests: not
O. V. Budnikova
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Postgraduate, Laboratory of Molecular and Cellular Pathology and Gene Diagnostics
Competing Interests: not
Russian Federation
Postgraduate, Laboratory of Molecular and Cellular Pathology and Gene Diagnostics
Competing Interests: not
R. E. Batalov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
PhD, Senior Research Scientist, Department of Surgical Arrhythmology and Cardiac Pacing
Competing Interests: not
Russian Federation
PhD, Senior Research Scientist, Department of Surgical Arrhythmology and Cardiac Pacing
Competing Interests: not
S. A. Afanasiev
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
PhD, professor, Chief of Laboratory of Molecular and Cellular Pathology and Gene Diagnostics
Competing Interests: not
Russian Federation
PhD, professor, Chief of Laboratory of Molecular and Cellular Pathology and Gene Diagnostics
Competing Interests: not
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Review
For citations:
Muslimova E.F., Rebrova T.Yu., Archakov E.A., Akhmedov Sh.D., Budnikova O.V., Batalov R.E., Afanasiev S.A. Polymorphic variants of genes encoding Ca(2+)-transporting sarcoplasmic reticulum proteins in the progression of chronic heart failure. Russian Journal of Cardiology. 2019;(10):48-52. (In Russ.) https://doi.org/10.15829/1560-4071-2019-10-48-52
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