New safety standards for anticoagulant therapy in the treatment of atrial fibrillation
https://doi.org/10.15829/1560-4071-2018-10-136-144
Abstract
The review article study the safety and efficacy of using direct acting oral anticoagulants: thrombin inhibitor dabigatran etexilate and inhibitors Xa of the blood clotting factor apixaban, rivaroxaban and edoxaban compared with the vitamin K antagonist warfarin in patients with non-valvular atrial fibrillation. The advantage of direct oral anticoagulants is emphasized. Particular attention is paid in the article to dabigatran etexilate, which demonstrated high efficacy and safety in randomized clinical trials and in actual clinical practice in patients with non-valvular atrial fibrillation. In addition, dabigatran etexilate in the composition of dual antiplatelet therapy in patients with coronary heart disease after stenting of the coronary arteries demonstrated greater safety than triple antithrombotic therapy, which included warfarin. The article shows indications for the use of dabigatran antagonist idaruzizumab and the method of its administration.
About the Author
E. I. Baranova
Pavlov First Saint-Petersburg State Medical University of the Ministry of Health; Almazov National Medical Research Center of the Ministry of Health
Russian Federation
Saint-Petersburg.
Competing Interests:
Russian Federation
Saint-Petersburg.
Competing Interests:
The paper was prepared with the support of Boehringer Ingelheim. The fact of support had not a bearing on the opinion of the author.
References
1. Chugh SS, Havmoeller R, Narayanan K, et al. Worldwide epidemiology of atrial fibrillation. Circulation. 2014;129(8):837-47 doi:10.1161/CIRCULATIONAHA.113.005119.
2. Schnabel RB, Yin X, Gona P, et al. 50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study. Lancet. 2015;386(9989):154-62. doi:10.1016/S0140-6736(14)61774-8.
3. Fisher M, Hill JA. Ischemic stroke mandates cross-disciplinary collaboration. Circulation. 2018;137(2):103-5. doi:10.1161/CIRCULATIONAHA117.032903.
4. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991;22:982-8. doi:10.1161/01.STR.22.8.983.
5. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann. Intern. Med. 2007;146:857-67. doi:10.7326/0003-4819-146-12-200706190-00007.
6. Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. The Task Force for the management of atrial fibrillation of the European Society of cardiology (ESC). Europ. Heart J. 2016;37(38):2893-962. doi:10.1002/ejhf.592.
7. Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Russian Journal of Cardiology. 2017;22(7):7-86. (In Russ.). doi:10.15829/1560-4071-2017-7-7-86.
8. Steffel J, Verhamme P, Potpora TS, et al. The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Europ. Heart J. 2018;00:1-64. doi:10.1093/eurheartj/ehy136.
9. Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl. J Med. 2009;361:1139-51. doi:10.1056/NEJMoa0905561.
10. Patel MR, Mahaffey KW, Garg J, et al. Rivarixaban versus Warfarin in Nonvalvular Atrial Fibrillation. N Engl J Med 2011;365:883-91. doi:10/1056/NEJMoa1009638.
11. Granger CB, Alexander JH, McMurray JJV, et al. Apixaban versus Warfarin in Patients with Atrial Fibrilation. N Engl J Med 2011;365:981-92. doi:101056/NEJMoa1107039.
12. Pradaxa; EU, SmpC, доступно по ссылке http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf 09 августа 2017.
13. Lip GYH, Clemens A, Noack H, et al. Patient outcomes using the European label for dabigatran. A post-hoc analysis from the RE-LY database. Thromb. Haemost. 2014;111:933-42. doi:10.1160/TH13-09-0734.
14. Graham DJ, Reichman ME, Wernecke M, et al. Cardiovascular, bleeding and mortality risks in elderly Medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation. Circulation. 2015;131:157-64. doi:10.1161/CIRCULATIONAHA.114.012061.
15. Hernandez I, Zhang Y. Comparing stroke and bleeding with rivaroxaban and dabigatran in atrial fibrillation: analysis of the US Medicare. Part D data. Am J Cardiovasc Drugs. 2017;17:37-47. doi:101007/s40256-016-0189-9.
16. Cannon CP, Bhatt DL, Oldgren J, et al. for the RE-DUAL PCI steering committee and investigators. Dual antithrombotic therapy with dabigatran after PCI in atrial fibrillation. N Engl J Med. 2017;377:1513-24. doi:10.1056/NEJMoa1708454.
17. Ando G, Capranzano P. Non-vitamin K antagonist oral anticoagulants in atrial fibrillation patients with chronic kidney disease: A systematic review and network meta-analysis. Int J Cardiol. 2017; 231:162-9. doi:10.1016/j.ijcard.2016.11.303
18. Desai JC, Chatterjee P, Friedman K, et al. Incidence and clinical presentation off gastrointestinal bleeding in patients taking direct oral anticoagulants. Am J Gastroenterol. 2016;3:13-21. doi:10.1038/ajgsup2016.3
19. Andresen K, Atar D, Gjertsen E, et al. Mechanisms of action and clinical use of specific reversal agents for non-vitamin K antagonist oral anticoagulants. Scand Cardiovasc J. 2018;52(3):156-162. doi:10.1080/14017431.2018.1453613
20. Niessner A, Tamargo J, Morais J, et al. Reversal strategies for non-vitamin K antagonist oral anticoagulants; a critical appraisal of available evidence and recommendations for clinical management — a joint position paper of the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy and European Society of Cardiology Working Group on Thrombosis. Eur. Heart J. 2017;38:1710-6. doi:10.1093/eurheartj/ehv676.
21. Diener HC, et al. Thrombolysis and thrombectomy in patients treated with dabigatran with acute ischemic stroke: Expert opinion. Intern. J of Stroke. 2017;12(1 ):9-12. doi:10.1177/1747493016669849.
22. Proietti M, Boriani G. Use of idarucizumab in reversing dabigatran anticoagulant effect: a critical appraisal.Therapeutic and Clinical Risk Management. 2018;14:1483-8. doi:10.2147/TCRMs140377.
23. Pollack CV, Reilly PA, Bernstein R, et al. Design and rationale for RE-VERSE AD: A phase 3 study of idarucizumab, a specific reversal agent for dabigatran. Thrombosis and Haemostasis. 2015;114(1):198-205. doi:10.1160/TH15-03-0192.
24. Pollack CV, Reilly PA, van Ryn J, et al. Idarucizumab for dabigatran reversal — full cohort analysis. New Engl J Med. 2017;377:431-41. doi:10.1056/NEJMoa1707278.
25. Levy JH, Ageno W, Chan NC, et al. When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH. J Thromb Haemost. 2016;14:623- 7. doi:10.1111/JTH.13227.
Review
For citations:
Baranova E.I. New safety standards for anticoagulant therapy in the treatment of atrial fibrillation. Russian Journal of Cardiology. 2018;(10):136-144. (In Russ.) https://doi.org/10.15829/1560-4071-2018-10-136-144
Views:
2251
Email this article 