High sympathetic tone in development of the left ventricle hypertrophy and beta-blockers for regression
https://doi.org/10.15829/1560-4071-2018-9-77-88
Abstract
The review is focused on clinical significance of the left ventricle hypertrophy (LVH) — presentation of heart lesion as a target organ for systemic hypertension (SH). Various LVH development mechanisms are presented, and special attention is paid to sympathic nervous system and β-adrenoreceptors in pathogenesis. Fundamental methods of diagnostics are described for LVH, in comparison. The pathology is classified from the perspective of recent guidelines on echocardiographic diagnostics. Epidemiology provided. Taken current evidence, the prognostic role of LVH is described as a factor increasing the risk of fatal and non-fatal cardiovascular, cerebrovascular and renal complications in SH patients. Trials data presented that points on LVH regression with highly selective β1-blocker bisoprolol treatment. Pathophysiology of LVH regression is discussed for β1-blocker treatment.
About the Authors
О. D. Ostroumova
A.I. Evdokimov Moscow State University of Medicine and Dentistry (MSUMD); I.M. Sechenov First Moscow State Medical University of the Ministry of Health (Sechenov University)
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
Conflicts of Interest nothing to declare
A. I. Kochetkov
A.I. Evdokimov Moscow State University of Medicine and Dentistry (MSUMD)
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
Conflicts of Interest nothing to declare
M. V. Lopukhina
E.O. Mukhin City Clinical Hospital of Moscow Healthcare Department
Competing Interests:
Moscow
Competing Interests:
Conflicts of Interest nothing to declare
E. Е. Pavleeva
A.I. Evdokimov Moscow State University of Medicine and Dentistry (MSUMD)
Competing Interests:
Competing Interests:
Conflicts of Interest nothing to declare
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For citations:
Ostroumova О.D., Kochetkov A.I., Lopukhina M.V., Pavleeva E.Е. High sympathetic tone in development of the left ventricle hypertrophy and beta-blockers for regression. Russian Journal of Cardiology. 2018;(9):77-88. (In Russ.) https://doi.org/10.15829/1560-4071-2018-9-77-88
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