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Genetic polymorphisms of matrix metalloproteinase-9, tissue inhibitor of matrix metalloproteinase-1 and development of postoperative atrial fibrillation in elderly patients

https://doi.org/10.15829/1560-4071-2018-10-48-52

Abstract

Aim. The aim of the study was to assess the association of genetic polymorphisms of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) with atrial fibrillation development in elderly patients with coronary artery disease (CAD), undergoing coronary artery bypass graft (CABG) surgery.

Material and methods. Studied were 80 patients who underwent CABG in 2015-2016 years. In all the patients routine laboratory and instrumental tests were performed. Patients also underwent genetic polymorphisms of ММР-9 А8202G and TIMP-1 C536T estimation with polymerase chain reaction. According to occurrence of postoperative atrial fibrillation (POAF) all the patients were divided into two groups: 1 group comprised 56 patients without POAF (81,8% males, mean age 65,9±4,0 years), 2 group — 24 patients with first detected episode of AF after CABG (875% males, mean age 67,7±5,4).

Results. According to results of multivariate regression analysis the odds ratio of POAF development in patients with stable angina grade III was 1,8 (95% CI 0,5-75, p=0,4), NYHA III — 0,85 (95% CI 0,2-3,5, p=0,55), history of CAD more than 20 months — 1,8 (95% CI 1,2-8,1, p=0,03), LA diameter more than 39 mm — 4,2 (95% CI 1,6-9,5, p<0,0001), allele G MMP-9 A8202G — 2,6 (95% CI 1,2-75, p=0,03).

Conclusion. In elderly patients undergoing coronary artery bypass graft surgery left atrial diameter more than 39 mm, history of coronary artery disease more than 20 months and the presence of G allele of MMP-9 A820G are significantly associated with postoperative atrial fibrillation occurrence.

About the Authors

A. O. Rubanenko
Samara state medical university
Russian Federation

Rubanenko Anatolii Olegovich - PhD, associate professor, Department of propaedeutic therapy.

Researcher ID: N-8413-2016


Competing Interests: The authors state no conflict of interests.


O. A. Rubanenko
Samara state medical university
Russian Federation

Rubanenko Olesya Anatol´evna — associate professor, PhD, Department of faculty therapy.

Researcher ID: I-8490-2015


Competing Interests:

The authors state no conflict of interests. 



L. V. Limareva
Samara state medical university
Russian Federation
Limareva Larisa Vladimirovna - Head of the Department of Immunology of the Institute of Experimental Medicine and Biotechnology, Doctor of Biological Sciences, Associate Professor, Department of faculty therapy.
Competing Interests: The authors state no conflict of interests.


Iu. V. Shchukin
Samara state medical university
Russian Federation

Shchukin Iurii Vladimirovich - The first prorector - prorector for educational and social work, the department of propaedeutic therapy, the head of the department, MD, professor, Department of faculty therapy.

Researcher ID: P-9959-2015

 


Competing Interests: The authors state no conflict of interests.


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Review

For citations:


Rubanenko A.O., Rubanenko O.A., Limareva L.V., Shchukin I.V. Genetic polymorphisms of matrix metalloproteinase-9, tissue inhibitor of matrix metalloproteinase-1 and development of postoperative atrial fibrillation in elderly patients. Russian Journal of Cardiology. 2018;(10):48-52. https://doi.org/10.15829/1560-4071-2018-10-48-52

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ISSN 1560-4071 (Print)
ISSN 2618-7620 (Online)