EFFECTIVENESS OF ANTIHYPERTENSION THERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION WORKING IN FAR NORTH
https://doi.org/10.15829/1560-4071-2015-4-94-99
Abstract
Aim. To evaluate combination treatment effectiveness by amlodipine with bisoprolol (A/B) on the data of 24-hour BP pattern in patients with arterial hypertension (AH) working in Far North.
Material and methods. Totally 140 patients studied with AH who were separated into 2 groups according to their working conditions: 1st group — 72 persons, working only daytime; 2nd group — 68 shift workers. All patients were prescribed combination therapy A/B with final dosages: 1st group 8,3±1,3/9,8±1,6 mg daily, 2nd group 9,5±1,5/14,5±1,2 mg daily. 24-hour BP values were studied at baseline, in 4 weeks and in 6 weeks of the treatment.
Results. In combination 6-months therapy by A/B in the 2nd group of AH patients comparing to the 1 st groupthere was lower rate of target BP achievement (87,9 and 92,9%, resp.). The "pressure load" parameters did not reach normal ranges in both groups, however were more significant in the 2nd group, that is why it is important to prescribe the 3rd hypotensive medication to these patients. We found BP variability normalization and improvement of morning BP dynamics in both groups that decreases the risk of cardiovascular complications. There was good tolerability.
About the Authors
I. L. Zapesochnaya
Bl Nizhnevartovsk City Polyclinics of Khanty-Mansiysky Autonomic District—Yugra, Nizhnevartovsk
Russian Federation
Russian Federation
A. G. Avtandilov
SBEI APE Russian Medical Academy of Postgraduate Education of HM, Moscow, Russia
Russian Federation
Russian Federation
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Review
For citations:
Zapesochnaya I.L., Avtandilov A.G. EFFECTIVENESS OF ANTIHYPERTENSION THERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION WORKING IN FAR NORTH. Russian Journal of Cardiology. 2015;(4):94-99. (In Russ.) https://doi.org/10.15829/1560-4071-2015-4-94-99
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