COMPLEX ASSESSMENT OF ARTERIES STIFFNESS PARAMETERS AND TRADITIONAL RISK FACTORS AS THE PREDICTORS OF EARLY VASCULAR AGEING SYNDROME

Aim. Evaluation of structural and functional properties of arteries in healthy persons and in coronary heart disease (CHD) patients with various severity of coronary lesion, in different age groups.

Material and methods. To the study, 135 patients included, with various CHD types, and 56 healthy persons at the age 35 to 65 y. o. All participants underwent laboratory testing for glucose level and lipid profile in blood. Applanation tonometry was done, and volumetric sphygmography, ultrasound scanning of common carotid arteries with the technology of high frequency RF signal.

Results. All participants were selected into two cohorts: younger and older than 50 y. o., which included patients with no hemodynamically significant stenoses of coronary arteries, with significant stenosis of one artery and healthy persons. According to the results of traditional risk factors analysis, CHD patients more prevalently had tobacco addiction, arterial hypertension, as well as family anamnesis of lipid disorders. By ultrasound scanning data of common carotid arteries, the parameters of arterial stiffness predominated in patients with coronary lesions. Applanation tonometry showed that CHD patients and healthy persons had comparable levels of central arterial pressure in both age groups. In all healthy persons the carotid-femoral pulse wave velocity was within normal range, and in CHD it was higher by 10 m/s. Volumetric sphygmography showed that severity of coronary lesion correlated with the increase of vascular rigidity parameters.

Conclusion. The results of current study confirm the necessity for development of novel criteria of risk assessment and prevention of cardiovascular diseases early development. Screening for predictors of early vascular ageing syndrome will make it to identify persons with low relative but high absolute risk of coronary events.

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