EFFECTS OF OMEGA-3 POLYUNSATURATED FATTY ACIDS ON THE CIRCADIAN RHYTHM OF HEART RATE VARIABILITY PARAMETERS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CARDIOVASCULAR AUTONOMIC NEUROPATHY
https://doi.org/10.15829/1560-4071-2018-5-56-60
Abstract
Aim. The aim of the study was to analyze the effect of a-3 polyunsaturated fatty acids (a-3 PUFAs) on the heart rate variability (HRV) parameters in patients with type 2 diabetes mellitus (T2DM) and advanced stage of cardiovascular autonomic neuropathy (CAN).
Material and methods. We have examined 36 patients with T2DM and advanced stage of CAN, aged between 50-59 years with disease duration 1-6 years and median glycated hemoglobin A1c 71%±0,12%. Patients with T2DM and advanced stage of CAN were divided into 2 groups. The first group received traditional antihyperglycemic therapy (n=15, control) for three mo; patients in group 2 (n=21) received in addition 1 g/day of the a-3 PUFAs for three months.
Results. Prescription of the a-3 PUFAs to the patients with T2DM and advanced stage of CAN was accompanied by a statistically significant increase of the timedomain HRV parameters; the spectral HRV parameters during the active and passive periods compared to the control group.
Conclusion. Obtained results suggest that the efficacy of a-3 PUFAs is the result of a direct effect of the a-3 PUFAs on the investigated indexes.
About the Authors
V. A. Serhiyenko
Lviv National Medical University named after Danylo Halytsky
Ukraine
Lviv
Ukraine
Lviv
V. B. Segin
2Lviv Regional State Clinical Treatment and Diagnostic Endocrinology Center
Ukraine
Lviv
Ukraine
Lviv
A. A. Serhiyenko
Lviv National Medical University named after Danylo Halytsky
Ukraine
Lviv
Ukraine
Lviv
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Review
For citations:
Serhiyenko V.A., Segin V.B., Serhiyenko A.A. EFFECTS OF OMEGA-3 POLYUNSATURATED FATTY ACIDS ON THE CIRCADIAN RHYTHM OF HEART RATE VARIABILITY PARAMETERS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CARDIOVASCULAR AUTONOMIC NEUROPATHY. Russian Journal of Cardiology. 2018;(5):56-60. https://doi.org/10.15829/1560-4071-2018-5-56-60
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