POSITIVE CLINICAL EFFECTS OF AN M-CHOLINOLYTIC IN IDIOPATHIC ARTERIAL HYPOTENSION
https://doi.org/10.15829/1560-4071-2018-2-102-106
Abstract
Aim. Evaluation of an m-cholinolytic influence on blood circulation, mental performance and fatigability, self-feeling in young women with idiopathic arterial hypotension (IAH).
Material and methods. The study object were 20 females with IAH defined as systolic BP ≤98 mmHg, age 19-32 y. o. The study subject — circulation parameters (SBP, DBP, HR), mental performance and fatigability by E. Kraepelin, self-rate of health (self-feeling). Experimental drug was taken once as one pill.
Results. In 1 hour post one dosage of the drug, there was SBP increase from 94 (92-96) mmHg to 108 (106-112) mmHg, and DBP and HR (p<0,05); increase of summations performed by 26% (p<0,01); improvement of self-feeling — in 45% of participants. In 24 h, 85% reported improvement of self-feeling.
Conclusion. In idiopathic arterial hypotension in young women one dosage of the m-cholinolytic shown the following positive effects: increase of SBP, DBP and mental performance (in 1 h) and improvement of self-feeling (in 1 h and 24 h).About the Authors
V. M. Baev
E. A. Wagner Perm State Medical University of the Ministry of Health
Russian Federation
Competing Interests: о конфликте интересов не сообщается
Russian Federation
Competing Interests: о конфликте интересов не сообщается
T. Yu. Agafonova
E. A. Wagner Perm State Medical University of the Ministry of Health
Russian Federation
Competing Interests: о конфликте интересов не сообщается
Russian Federation
Competing Interests: о конфликте интересов не сообщается
References
1. Baev VM, Koryukina IP, Kudryavtseva EN, et al. Cardiac hypotrophy in young women with low blood pressure. Biology and Medicine (Aligarh) 2014; 6 (1): 1-7. http://www.biolmedonline.com/Articles/Vol6_1_2014/BM-005-14_Baev_et_al.pdf.
2. Baev VM, Agafonova TYu, Samsonova OA. Mental performance and fatigue in young women with idiopathic arterial hypotension. The Doctor 2016, 12: 59-61. (In Russ.) Баев В. М., Агафонова, Самсонова О. А. Умственная работоспособность и утомляемость молодых женщин с идиопатической артериальной гипотензией. Врач 2016, 12: 59-61.
3. Ciaroni S. Faut-il avoir peur de la pression artérielle chronique constitutionnelle basse? Rev Med Suisse 2011; 7: 544-47.
4. Sukalo AV, Sikorski AV, Pereverzev VA. Vegetative and endothelial functions in children with primary arterial hypotension. Vestnik of the Smolensk State Medical Academy 2017; 16 (1): 115-20. (In Russ.) Сукало А. В., Сикорский А. В., Переверзев В. А. Вегетативная и эндотелиальная функции у детей с первичной артериальной гипотензией. Вестник Смоленской государственной медицинской академии 2017, 16 (1): 115-20.
5. Baev VM, Agafonova TYu, Samsonova OA, et al. Isolated diastolic dysfunction as a result of hypernitricoxidemia in arterial hypotension. Cardiovascular Therapy and Prevention 2017; 5: 16-9. (In Russ.) Баев В. М., Агафонова Т. Ю., Самсонова О. А. и др. Изолированная диастолическая дисфункция как результат гипероксидазотемии при артериальной гипотензии. Кардиоваскулярная терапия и профилактика 2017, 5: 16-9. DOI: 10.15829/1728-8800-2017-5-16-19.
6. Adams JG. Emergency Medicine: Clinical Essentials (Expert Consult — Online and Print), 2nd Edition. Elsevier Health Sciences. 2012. 1888 p. Chapter
7. Cardiac Arrest Management and the Post-Cardiac Arrest Syndrome. P. 55-71. ISBN-13: 9781437735482. 7. 2013 ESH/ESC Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). European Heart Journal 2013; 34: 2159-219. DOI: 10.1093/eurheartj/eht151.
8. Eliseev OP. Workshop on the psychology of personality. St. Petersburg: Publishing House “Peter” 2010; 507 р. (In Russ.) Елисеев О. П. Практикум по психологии личности. СПб.: Издательский дом “Питер”, 2010; 507 c. ISBN 5-272-00115-Х. с.104-105.
9. Duschek S, Heiss H, Buechner B, et al. Hemodynamic determinants of chronic hypotension and their modification through vasopressor application. J Physiol Sci 2009; 59 (2): 105-12. DOI: 10.1007/s12576-008-0015-5.
10. Becker DE. Basic and Clinical Pharmacology of Autonomic Drugs. Anesth Prog 2012; 59 (4): 159-69. DOI: 10.2344/0003-3006-59.4.159.
11. Lancaster R. Pharmacology in Clinical Practice. Elsevier. 2013. 612 р. chapter 10. Cholinergic and Anticholinergic Drugs. р.113-31. ISBN: 9781483192949.
12. Mann DL, Zipes DP, Libby P, et al. Braunwald’s Heart Disease E-Book: A Textbook of Cardiovascular Medicine. 10th ed. Elsevier Health Sciences. 2014. 2136 р. chapter 40. Hypotension and Syncope. P. 861-71. ISBN: 9780323290647.
13. Gahart BL, Nazareno AR. 2018 Intravenous Medications: A Handbook for Nurses and Health Professionals. 34rd. Elsevier Health Sciences. 2017. 1440 р. ISBN: 9780323298452. P.148-50.
14. Otto CM. Textbook of Clinical Echocardiography E-Book. 5th ed. Elsevier Health Sciences. 2016 г. 558 р. ISBN: 978-1-4557-2857-2. Chapter 6. Left and Right Ventricular Systolic Function. P.131-87.
15. Choi WJ, Lee K, Kim YK, et al. Vagolytic atropine attenuates cerebral vasodilation response during acute orthostatic hypotension. Korean J Anesthesiol 2015; 68 (6): 594-602. DOI: 10.4097/kjae.2015.68.6.594.
Review
For citations:
Baev V.M., Agafonova T.Yu. POSITIVE CLINICAL EFFECTS OF AN M-CHOLINOLYTIC IN IDIOPATHIC ARTERIAL HYPOTENSION. Russian Journal of Cardiology. 2018;(2):102-106. (In Russ.) https://doi.org/10.15829/1560-4071-2018-2-102-106
Views:
754
Email this article 