Bolus streptokinase administration in acute myocardial infarction: features of hypotensive reaction
Abstract
Hypotension prevalence and severity was investigated in two regimens of streptokinase (SK) administration in acute myocardial infarction (AMI). Group I (n = 17) received intravenous SK, 0.75 mln IE, in 10 minutes; Group II (n = 9) - 1.5 mln IE, in 45 minutes. In bolus SK administration, maximal blood pressure (BP) decrease was comparable to that in slow infusion group, but observed earlier - at minute 7.5 ± 0,4, vs minute 12.5 ± 6.8 (p = 0.003). In Group I, 3 cases of collapse were registered, with little effect from mezaton administration. Significant BPfall could be expected in patients with posterior MI, right wall damage and bradycardia. To prevent severe hypotensive reaction, bolus SK administration should be optimized.
About the Authors
V. A. Stolyarov
НИИ кардиологии Томского научного центра СО РАМН
Russian Federation
Russian Federation
I. V. Maksimov
НИИ кардиологии Томского научного центра СО РАМН
Russian Federation
Russian Federation
V. A. Markov
НИИ кардиологии Томского научного центра СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Stolyarov V.A., Maksimov I.V., Markov V.A. Bolus streptokinase administration in acute myocardial infarction: features of hypotensive reaction. Russian Journal of Cardiology. 2005;(2):38-42. (In Russ.)
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