Vasoregulating endothelial function in essential arterial hypertension and chronic heart failure
Abstract
Mechanisms of vascular tonus regulation in patients with essential arterial hypertension (EAR) and chronic heart failure (CHF) were examined by high-definition ultrasound method. EAH patients demonstrated substantially disturbed endothelium-dependent mechanisms of vascular tonus regulation, with intact endothelium-independent mechanisms. In CHE individuals, both endothelium-dependent and independent vascular reactions were disturbed. The observed changes in vasomotor reactions might precede morphological changes in vascular wall.
About the Authors
Ya. I. Kots
Оренбургская государственная медицинская академия МЗ и СР РФ
Russian Federation
Russian Federation
E. H. Denisov
Оренбургская государственная медицинская академия МЗ и СР РФ
Russian Federation
Russian Federation
R. Z. Bakhtiyarov
Оренбургская государственная медицинская академия МЗ и СР РФ
Russian Federation
Russian Federation
N. V. Maslova
Оренбургская государственная медицинская академия МЗ и СР РФ
Russian Federation
Russian Federation
References
1. Затейщикова А.А., Затейщиков Д.А. Эндотелиальная регуляция сосудистого тонуса: методы исследования и клиническое значение. // Кардиология. 1998. № 9. С. 68-80.
2. Карпов Ю.А. Роль нейрогуморальных систем в развитии и прогрессировании хронической сердечной недостаточности: эндотелиальные факторы. // Сердечная недостаточность. 2002. Т. 3, № 1. С. 23.
3. Сидоренко Б.А., Затейщиков Д.А. «Дисфункция эндотелия» в патогенезе атеросклероза и его осложнений.//Кремлевская медицина. Клинический вестник. 1999. № 2. С. 2-19.
4. Cadrillo С., Kilcoyne С.М., Quyyumi A., et al. Selective defect in nitric oxide syntesis may explain the impaired endothelium-dependent vasodilation in essential hypertension. Circulation. 1998; 97: 851-6.
5. Celermajer D.S., Sorensen K.E., Gooch V.M., et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. // Lancet. 1992. Vol. 340 (8828). P. 1111-1115.
6. Furchgott R.F., Vanhoutte P.M. Endothelium-derived relaxing and contracting factors. FASEB J. 1989. Vol. 3. P. 2007-2018.
7. Lusher T.F., Barton M. Biology of the endothelium.//Clin Cardiol. 1997. Vol. 20 (11 Suppl 2): II. P. 3-10.
8. Vanhoutte P.M., Mombouli J.V. Vascular endothelium: vasoactive mediators.//Prog. Cardiovasc. Dis. 1996. Vol. 39. R. 229-238.
9. Vaughan D.E., Rouleau J-L., Ridker P.M., et al. Effects of ramipril on plasma fibrinolytic balance in patients with acute anterior myocardial infarction. // Circulation. 1997. Vol. 96. P. 442-447.
Review
For citations:
Kots Ya.I., Denisov E.H., Bakhtiyarov R.Z., Maslova N.V. Vasoregulating endothelial function in essential arterial hypertension and chronic heart failure. Russian Journal of Cardiology. 2005;(3):16-19. (In Russ.)
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