Oxidative metabolism of polymorph nuclear leucocytes and cardiovascular metabolic syndrome development in males
Abstract
In 214 males with arterial hypertension (AH), divided into groups according to metabolic disorder quantity, and 45 healthy males, oxidative metabolism of polymorph nuclear leukocytes (OMPL) was assessed by chemiluminescent (CL) method. The possible association between parameters obtained and insulin-glucose parameters was investigated. Metabolic syndrome clustering was associated with non-linear OMPL progression. Stages of leukocyte functional status change were identified and described. Correlations between insulin-glucose parameters and CL indices varied according to metabolic disorders' severity in AH patients. The results support initial, pro-oxidant role of hyperinsulinemia, realized via OMPL increase at early stages of metabolic syndrome development in males.
About the Authors
L. A. Ruyatkina
Новосибирская государственная медицинская академия
Russian Federation
Russian Federation
Z. G. Bondareva
Новосибирская государственная медицинская академия
Russian Federation
Russian Federation
A. R. Antonov
Новосибирская государственная медицинская академия
Russian Federation
Russian Federation
References
1. Руяткина Л.А., Галенок В.А. Патогенетические особенности нарушений углеводного обмена при гипертонической болезни.//Диабетография, 1996. -№6. С. 19-23.
2. Nunes J.S., Correia L.G., Соггеа J.N. No title available.//Acta Med.Port. -2000. -V.13. -N.4. -P. 203-210.
3. Маянский Д.Н. Хроническое воспаление. М.: Медицина, 1991. -271 с.
4. Chen S.S., Monteiro H.P., Deucher G.R et al. Functional activity of blood polymorphonuclear leucocyte as an oxidative stress biomarker in human subjects//Free Radic. Biol. Med. -1998. -V.24. -<http://Radic.Biol.Med.-1998.-V24.->N.9. -P. 1411-1418.
5. Kopprasch S., Graessler J., Seibt R. et al. Leucocytes responsiveness to substances that activate the respiratory burst is not altered in borderline and essential hypertension//J.Hum.Hypertens. -1996. -V.10. -N.2. -P. 69-76.
6. Kristal В., Shurtz-Swirski R., Chezar J. et al. Participation of peripheral of polymorphonuclear leucocytes in oxidative stress and inflammation in patients with essential hypertension//Am. J. Hypertens. -1998. -V.11. -N.8 pt.l. -P. 921-928.
7. Delamaire M., Maugendre D., Moreno M. et al. Impaired leucocyte in diabetes patients//Diabet. Med. -1997. -V. 14. -N.l. -P. 29-34
8. Ohmori M., Harada K., Kitoh Y et al. The functions of circulatory polymorphonuclear leucocyte in diabetes patients with and without diabetic triopathy//Life Sci. -2000. -V.66. -N.19. -P. 1861-1870.
9. Wierusz-Wysocka В., Kubicka M., Wykretowicz A. et al. Superoxide anion production and adhesiveness of neutrophils in obese patients//Pol.Arch.Med.Wewn. -<http:// href='contents.asp?titleid=21974' title='Polskie Archiwum Medycyny Wewnetrznej'>Pol.Arch.Med.Wewn.->1989. -V.82. -N. 2-3. -P. 980104. 18.
10. Yasuda M., Shimizu S., Tokuyama S. et al. A novel effect of polymorphonuclear leucocytes in the facilitation of angiogenesis//Life Sci. -2000. -V.66. -P. 2113-2121.
11. Ide Т., Tsutsui H., Ohashi N. et al. Greater oxidative stress in healthy young men compared with premenopausal women.//Arterioscler. Thromb. -2002; V.22. -P. 438-42.
12. Руяткина Л.А., Галенок В.А., Бондарева З.Г. Анализ информативности показателей инсулинглюкозного гомеостаза у больных с метаболическим синдромом X.//Тер.арх. -2002. -№ 4. -С. 63-65.
13. Климов Ф.Н., Никульчева Н.Г. Обмен липидов и липопротеидов и его нарушения. -СПб: Питер Ком, 1999. -512 с.
14. Das R.K., Muddeshwar M.G. Alteration in the activities of the membrane-integrated enzymes of polymorphonuclear leucocyte in obesity//Indian Heart J. -1997. -V.49. -N.5. -P. 521-524.
15. Aleksandrovski Y.A. Molecular mechanisms of diabetic complications//Biochemistry. -1998. -V.63. -N.11 <http:// href='contents.asp?titleid=13560' title='Biochemistry'>Biochemistry.-1998.-V.63.-N.il>. -P. 1249-1257.
16. Targher G., Seidell J.C., Tonoli M. et al. The white blood cell count: its relationship to plasma insulin and other cardiovascular risl factors in healthy male individuals//J. Intern.Med. -1996. -V. 239. -N5. -P. 435-441.
17. Zimmet P., Boyko E.J., Collier G.R. et al. Etiology of the metabolic syndrom: potential role of insulin resistant, and other players//Ann. N.Y.Acad.Sci. -1999. -V. 892. -P. 25-44.
18. Muller-Weland D., Kotzka J., Knebel B. et al. Metabolic syndrome and hypertension: pathophysiology and molecular basis of insulin resistance//Basic Res.Cardio. -1998. -V. 93. -S.2. -P. 131-134.
Review
For citations:
Ruyatkina L.A., Bondareva Z.G., Antonov A.R. Oxidative metabolism of polymorph nuclear leucocytes and cardiovascular metabolic syndrome development in males. Russian Journal of Cardiology. 2005;(4):36-41. (In Russ.)
Views:
623
Email this article 