REGIONAL ASPECTS OF THE GENE POLYMORPHISM VЕGFR2 WITH CORONARY ATHEROSCLEROSIS IN ACUTE CORONARY SYNDROME

Aim. Evaluation of the associations of allele variant of gene VЕGFR2 rs2305948 with atherosclerotic  lesion  of  coronary  arteries   in acute   coronary  syndrome  (ACS)  patients in the North (Surgut city) and big cities of the Siberian Federal District (SFD) (Novosibirsk, Irkutsk, Kemerovo).

Material  and  methods. Totally, 258  consecutive  ACS patients  investigated,  at admission  to cardiological in-patient  clinics of big cities of the North (Surgut, 78 patients) and SFD (180 patients). All patients underwent coronary arteriography and genetic test (the allele variant assessment VЕGFR2 rs2305948).

Results. In Surgut patients the allele variant VЕGFR2*CC is directly linked with the lesion  of  proximal  and  intermediate   part  of  three  main  arteries   >70%  (PTA) (χ²=4,68; p=0,031), PTA and left main stem stenosis >50% (χ²=7,02; p=0,008), and in patients from SFD VЕGFR2 *CT + *TT is directly associated with hypercholesterolemia (HC) (χ²=8,53; p=0,003). Combination of allele variant VЕGFR2*CC with HC directly influences PTA of stem stenosis >50% in ACS patients  in Surgut (Exp (B) =4,441; 95% CI (1,351; 14,601); p=0,014). Combination of allele variant VЕGFR2*CC with HC directly influences stenosis >70% existence in at least three coronary arteries, in Surgut patients (Exp (B): 3,697; 95% CI (1,304; 10,486);p=0,014), as in SFD patients exp (B): 4,460; 95% CI (1,306; 15,236); p=0,017).

Conclusion. Allele variant VЕGFR2*СС does directly influence the existence of coronary atherosclerosis of various grade severity in patients with ACS in the North, and if combined with VЕGFR2*СС and HC is also a risk factor for coronary atherosclerosis not only in the North but in SFD cities as well.

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