Neurohumoral activation in arterial hypertension pathogenesis among patients with hypoD and hyperthyrosis
Abstract
Activity of renin-angiotensin-aldosterone and sympatho-adrenal systems (RAAS, SAS) in arterial hypertension combined with hypo- or hyperthyrosis was investigated. RAAS activity was decreased in hypothyrosis, and increased in hyperthyrosis; SAS activity was enhanced both in hypo- and hyperthyrosis. These data correlate with the results of 24-hour blood pressure monitoring, and previous studies' results. The authors conclude that RAAS and SAS might play a role in AH pathogenesis among patients with hypo- or hyperthyrosis.
About the Authors
P. Kh. Dzhanashiya
Российский государственный университет
Russian Federation
Russian Federation
G. B. Selivanova
Российский государственный университет
Russian Federation
Russian Federation
References
1. Матвеенко Е.Г., Горобец В.Ф., Дустов А.Д. Состояние ренин-ангиотензин-альдостероновой системы при патологии щитовидной железы, основанное на результатах радиоимунного метода//Тер. Архив. -1987. -№11. -стр. 41-44.
2. Ром-Бугословская Е.С., Комарова И.В. Регуляция секреции альдостерона при тиреотоксикозе. Тиреоидные гормоны как возможные стимуляторы активности ренин-ангиотензин-альдостероновой системы//Проблемы эндокринологии. -1986. -№2. -стр.13-16.
3. Старкова Н.Т. Клиническая эндокринология. Москва. «Медицина», 1991. с. 511.
4. Чазова И.Е. Применение ингибиторов АПФ в лечении артериальной гипертонии//Русский медицинский журнал. -2000. -Т.8. -№15-16. -с. 610-613.
5. Asmah B.J., WanNazaimoon W.M., Nozarmi K. et al. Plasma renin and aldosteron in thyroid disease//Horm. Metab. Res. -1997. -№11. -p. 580-583.
6. Bing R.F., Briggs R.S., Burden A.C. et al. Reversible hypertension and hypothyroidism//Clin. Endocrinol. (Oxf). -1980. -Vol.13. -№4. -p. 339-42.
7. Bramnert M., Hallengren В., Lecerof H. et al. Decreased blood pressure response to infused noradrenaline in normotensive as compared to hypertensive patients with primary hypothyroidism//Clin. Endocrinol. (Oxf). -1994. -Vol.40. -№3. -p. 317-321.
8. Brown R.T., Laksmanan M.C., Baucom C.E., Polinsky R.L. Changes in blood pressure and plasma noradrenaline in short-term hypothyroidism//Clin. Endokrinol.(Oxf). -1989. -Vol.30. -№6. -p. 635-638.
9. Coulombe P., Dussault J., Letarte J., Simmard S. Catecholamine metabolism in thyroid disease. I. Epinephrine secretion rate in hyperthyroidism and hypothyroidism//J. Clin. Endocrinol. Metab. -1976. -№1. -р. 125-131.
10. Coulombe P., Dussault J., Walker P. Plasma catecholamine concentration in hyperthyroidism and hypothyroidism//Metabolism. -1976. -№9. -p. 973-979.
11. Egart F.M., Atamanova T.M., Nazarov A.N. Aldosteron content and renin activity in the plasma of hypothyroidism patients before and during treatment with preparations//Probl. Endokrinol. -1986. -Vol.32. -№1. -p. 35-38.
12. Elias A.N., Kyaw Т., Valenta L.J., Mashkinpour H. The renin-angiotensin system in hypothyroidism of short duration//Horm. Metab. Res. -1986. -Vol.18. -№5. -p. 349-351.
13. Fletcher A.K., Weetman A.P Hypertension and hypothyroidism//J. Hum. Hypertens. -1998. -Vol.12, -p. 79-82.
14. Fommei E., Conti A., Gazetti P., et al. Neuro-adrenal and blood pressure responses to short-term hypothyroidism//American J. of Hypertension. -2001. -Vol.14. -Iss.4. -p. A253-A254.
15. Fregly M.J., Resch G.E., Nelson E.L. et al. Effect of hypothyroidism on responsiveness to beta-adrenergic stimulation//Can. J. Physiol. Pharmacol. -1976. -Vol.54. -№3. -p. 200-208.
16. Garcia-Estan J., Atucha N.M., Quesada Т., Vargas F. Involvement renin-angiotensin system in the reduced pressure natriuresis response of hyperthyroidrats//Am. J. Physiol. -1995. -№5. -p. E897-901.
17. Klein J., Ojama K. Thyroid disease and cardiovascular system: from theory to practice//J. Clin. Endocrinol. Metab. -1994. -Vol.78. -p. 1026-1227.
18. Klemperer J.D., Ojama K., Klein I. Thyroid hormone therapy in cardiovascular disease//Prog. Cardiovasc. Dis. -1996. -Vol.38. -№4. -p. 329-336.
19. Kuchel O., Buu N.T., Hamet P., Larochelle P. Hypertension in hyperthyroidism: is there an epinephrine connection?//Life Sci. -1982. -№2. -p. 603-609.
20. Levej G.S. Catecholamine sensitivity, thyroid hormone and the heart: areevalution//Am. J. Med. -1971. -Vol.50, -p. 413-420.
21. Manhem P., Hallengren В., Hansson B.G. Plasma noradrenaline and blood pressure in hypothyroid patients: effeat of gradual thyroxine treatment//Clin. Endocrinol. (Oxf). -1984. -Vol.20. -№6. -p.701-707.
22. Marchant C., Brown L., Sernia S. Renin-angiotensin system in 29.thyroid dysfunction in rats//J. Cardiovasc. Pharmacol. -1993. -Vol.22. -№3. -p. 449-455.
23. McDevitt D.G., Riddel J.G., Hadden D.R., Montgomery D.A. Catecholamine sensitivity in hyperthyroidism and hypothyroidism//Br. J. Clin. Pharmacol. -1978. -№10. -p. 297-301.
24. Montiel M., Jimenez E., Narvaez J.A., Morell M. Renin-angiotesin-aldosteron system in hyper-and hypothyroid rats during sodium depletion//Endocr. Res. Commun. -1982. -Vol.9. -№3-4. -p. 249-260.
25. Nakamura Y., Takeda T, Ishii M. et al. Elevation of serum angiotensin-converting enzyme activity patients with hyperthyroidism//J. Endocrinol Metab. -1982. -№11. -p. 931-934.
26. Polikar R., Burger A.J., Sherner U., Nicod P. The thyroid and the heart: areevaluation//Circulation. -1993. -Vol.87, -p. 1435-1441.
27. Reiners C., Gramer-Kurz E., Pikert E., Schweisfurth H. Changes of serum angiotensin-I-converting enzyme in patients with thyroid disorders//clin Physiol. Biochem. -1998. -№6. -p.44-49.
28. Velardo A., Del Rio G., Zizzo G. et al. Plasma cateholamines after thyrotropin-releasing hormone administration in hypothyroid patients before and during therapy//Eur. J. Endocrinol. -1994. -Vol.130. -№3. -p. 220-223.
Review
For citations:
Dzhanashiya P.Kh., Selivanova G.B. Neurohumoral activation in arterial hypertension pathogenesis among patients with hypoD and hyperthyrosis. Russian Journal of Cardiology. 2005;(5):34-39. (In Russ.)
Views:
1028
Email this article 