Increased risk of platelet thrombosis stimulated by hypomagnesiemia in acute myocardial infarction
Abstract
A randomized pilot study was performed in coronary heart disease (CHD) patients (ejection fraction, EF, close to 40%; diastolic dysfunction) after primary anterior-septal myocardial infarction (MI), complicated with acute heart failure of Killip functional class II-III, Stage II-III arterial hypertension, and platelet magnesium level <1,2 mkmol/mg of protein. Magnesium deficit in plasma, even without severe hypomagnesimia in serum, impaired endothelial secretion of plasminogen activators, and reduced blood fibrinolytic activity, combined with enhanced platelet secretion of serotonin - inflammatory marker and powerful vasoconstrictor. levels of plasma magnesium and fibrinogen directly correlated ([MgJ = 0,37[fibrinogen] + 0,38; r = 0,67, p<0,02). It could be concluded that severe arterial hypertension combined with magnesium deficit play an important role in platelet hemostasis disturbances and high fibrinogen level resistance towards standard MI treatment.
About the Authors
N. A. Andriadze
НИИ клинической и экспериментальной кардиологии им. М.Д. Цинадзгвришвили, Тбилиси
Georgia
Georgia
M. A. Kobalava
НИИ клинической и экспериментальной кардиологии им. М.Д. Цинадзгвришвили, Тбилиси
Georgia
Georgia
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Review
For citations:
Andriadze N.A., Kobalava M.A. Increased risk of platelet thrombosis stimulated by hypomagnesiemia in acute myocardial infarction. Russian Journal of Cardiology. 2004;(6):14-17. (In Russ.)
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