Inflammatory markers and their association with main cardiovascular risk factors in patients with atrial fibrillation and arterial hypertension
Abstract
According to modern views, immuno-inflammatory activation plays an important role in atrial fibrillation (AF) pathogenesis. In 97patients with arterial hypertension (AH), paroxysm and non-paroxysm levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and fibrinogen were measured in 97 patients with permanent, persisting recurrent atrial fibrillation (AF). During AF paroxysm, TNF-alpha levels were significantly increased (p = 0,0001), in contrast with relatively stable CRP and fibrinogen levels (p > 0,05). CRP inversely correlated with AF severity (p = 0,0001). TNF-alpha levels were inversely associated with high-density lipoprotein cholesterol concentration in AF-free hypertensives, AH and permanent AF individuals, and persistent recurrent AF patients during the paroxysm. AF paroxysms were linked to increased TNF-alpha concentration. The correlation between main cardiovascular risk factors and inflammatory markers was observed.
About the Author
O. A. Tarasova
Пермская государственная медицинская академия им. Е.А. Вагнера
Russian Federation
Russian Federation
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Review
For citations:
Tarasova O.A. Inflammatory markers and their association with main cardiovascular risk factors in patients with atrial fibrillation and arterial hypertension. Russian Journal of Cardiology. 2007;(3):18-22. (In Russ.)
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