A STABILITY OF CARDIOVASCULAR RISK FACTORS BY THE 17-YEAR OBSERVATIONAL STUDY

While planning treatment and prevention in cardiovascular disorders (CVD) it is important to take into account the data on stability of clinical course of the main risk factors (RF). Until recently there is no such data on Russian population. Aim. To study the stability of arterial hypertension (AH), overweight (OW), hypercholestrolemia (HCE), hypertriglyceridemia (HTE) among men and women in 17-year observation. Material and methods. Baseline testing on the base of randomly assigned selection from the city of Tomsk citizens was performed in 1988-1991 (1546 men and women 20-59 y.  o.). Second test was done in 2002-2005, and the data obtained on RF and endpoints in 81,2% persons from the first step. A stability factor (St) was defined as relation of repeated RF (RF2) to the general selection (RF1), in percent — St=RF2/RF1 x 100%. Also the regression of RF was calculated. As regression we defined the cases of nonfinding of RF in the second measurement while having this in the first, and calculated by 1000 person-years of observation (PEO). Results. Seventeen-years lasting prospective study, performed on the cohort of men and women 20-59 y.  o. showed a high stability of AH, OW, HCE. The St values for AH was 96,6% (regressed 2,31 cases by 1000 PEO), for HCE; St for OW — 92,7% (regressed 4,70 by 1000 PEO); St for HCE — 92,9% (regressed 4,53 by 1000 PEO). HTE was not so stable RF: St = 75,0%. In age subgroup of 20-29 y. the interrelation of lower stability for HCE and HTE was found — St for HCE was 85,0% (regression 9,37 cases by 1000 PEO); St for HTE — 50,0% (regression 30,38 per 1000 PEO). It suggests that the nonmedication methods for dyslipoproteidemia correction, as diet, physical exertion increase, smoking cessation, body mass decrease can be highly effective in young people.

1. Oganov RG, Shalnova SA, Kalinin AM. Prevention of cardiovascular disease: a guide. M.: GEOTAR-Media 2009. Russian (Оганов Р. Г., Шальнова С. А., Калинина А. М. Профилактика сердечно-сосудистых заболеваний: руководство. М.: ГЭОТАР-Медиа 2009).

2. Prevention of chronic non-communicable diseases: recommendations. М.: 2013; 136 p. Russian (Профилактика хронических неинфекционных заболеваний: рекомендации. М.: 2013; 136 с).

3. Cooney MT, Dudina A, D’Agostino R, Graham IM Cardiovascular Risk-Estimation Systems in Primary Prevention : Do They Differ? Do They Make a Difference? Can We See the Future? Circulation 2010; 122: 300-10.

4. Hopstock LA, Barnett AG, Bønaa KH, et al. Seasonal variation in cardiovascular disease risk factors in a subarctic population: the Tromsø Study 1979-2008. J Epidemiol Community Health 2013; 67(2): 113-8.

5. Jacobsen BK, Eggen AE, Mathiesen EB, et al. Cohort profile: The Tromsø Study. Int. J. Epidemiol 2012; 41: 961-7.

6. Borena W, Stocks T, Ulmer H, et al. Long-term temporal trends in cardiovascular and metabolic risk factors. Wiener klinische Wochenschrift 2009; 121: 623-30.

7. Bugge A, El-Naaman B, McMurray RG, et al. Tracking of clustered cardiovascular disease risk factors from childhood to adolescence. Pediatr Res 2013; 73(2): 245-9.

8. Ghannem H, Ben Abdelaziz A, Limam K, et al. Tracking of cardiovascular risk factors among school children: a four-year population surveillance in Susa, Tunisia. Tunis Med 2005; 83(7): 404-8.

9. Laclaustra-Gimeno M, González-García MP, Casasnovas-Lenguas JA, et al. Cardiovascular Risk Factor Progression in Young Males at 15-Year Follow-Up in the General Military Academy of Zaragoza (AGEMZA) Study. Rev Esp Cardiol 2006; 59: 671-8.

10. Konstantinov VO, Lipovetsky BM, Shestov DB, et al. The dynamics of the leading risk factors for coronary heart disease in a population of men older than 40 years from prospective epidemiological surveillance. Terapevticheskij arhiv 1987; 1: 18-21. Russian (Константинов В. О. Липовецкий Б. М., Шестов Д.Б и др. О динамике ведущих факторов риска ишемической болезни сердца в популяции мужчин старше 40 лет по данным проспективного эпидемиологического наблюдения. Тер. архив 1987; 1: 18-21.

11. Meteliсa VI, Kokurina EV Ostrovskaja TP, et al. The main results of a prospective long-term observation of the male population. Cardiology 1983; 6:85-91. Russian (Метелица В. И., Кокурина Е. В., Островская Т. П. и др. Основные результаты многолетнего проспективного наблюдения за мужской популяцией. Кардиология 1983; 6: 85-91).

12. Bobrie G, Clerson P, Ménard J, et al. Masked hypertension: a systematic review. J Hypertens. 2008; 26(9): 1715-25.

13. All about cholesterol: a national report. Ed. LA Boqueria, RG Oganov. M. NTSSSH them. Bakulev RAMS 2010. Russian (Всё о холестерине: национальный доклад. Под ред. Л. А. Бокерия, Р. Г. Оганова. М.: НЦССХ им. А. Н. Бакулева РАМН. 2010).

14. Ford ES, Li C, Pearson WS. Trends in hypercholesterolemia, treatment and control among United States adults. Int J Cardiol 2010; 140: 226-35.

15. Guidelines Committee 2007. European Society of Hypertension European Society of Cardiology Guidelines for the management of arterial hypertension. J. Hypertens 2007; 25: 1105-87.

16. Dolgalev IV, Tsimbalyuk IV, Obraztsov VV, et al. Dynamics of arterial hypertension depending on change of weight of a body, according to the results of a 17-year prospective study. Bulletin of Siberian Medicine 2012; 1: 150-5. Russian (Долгалёв И. В., Цимбалюк И. В. Образцов В. В. и др. Динамика артериальной гипертонии в зависимости от изменения массы тела, по результатам 17-летнего проспективного исследования. Бюллетень сибирской медицины 2012; 1: 150-5).

17. Dolgalev IV, Obraztsov VV, Tsimbalyuk IV, et al. The natural dynamics, treatment and control of Hypertension (according to the results of a 17-year prospective study). Profilakt. medicina 2011; 3: 41-5. Russian (Долгалёв И. В., Образцов В. В., Цимбалюк И. В. и др. Естественная динамика, лечение и контроль артериальной гипертонии (по результатам 17-летнего проспективного исследования). Профилактическая медицина 2011; 3: 41-5).